The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

Biochemical Journal

Volumn 419, Issue 1, 2009, Pages 57-63

  Plant, Pamela J ^a   Correa, Judy ^a   Goldenberg, Neil ^a   Bain, James ^b   Batt, Jane ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Inositol phosphatase; Muscle atrophy; Myotubularin; Myotubularin related protein 4 (MTMR4); Neural precursor cell expressed developmentally down regulated 4 (Nedd4); Ubiquitin ligase

Indexed keywords

INOSITOL PHOSPHATASE; MUSCLE ATROPHY; MYOTUBULARIN; MYOTUBULARIN-RELATED PROTEIN 4 (MTMR4); NEURAL-PRECURSOR-CELL-EXPRESSED DEVELOPMENTALLY DOWN-REGULATED 4 (NEDD4); UBIQUITIN LIGASE;

ALCOHOLS; MUSCLE; PROTEINS; SUGARS;

ENZYMES;

PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PROLINE; PROTEIN MTMR4; TRYPTOPHAN; TYROSINE; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; MTMR4 PROTEIN, HUMAN; NEDD4 UBIQUITIN PROTEIN LIGASES; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MUSCLE ATROPHY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ANIMAL; CELL LINE; HELA CELL; MALE; METABOLISM; MUSCLE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT; UBIQUITINATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MALE; MUSCLES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR; RATS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 62749111349     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081866     Document Type: Article

References (33)

1. Staub, O. and Rotin, D. (2006) Role of ubiquitylation in cellular membrane transport. Physiol. Rev. 86, 669-707
2. Pickart, C. M. (2001) Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533
3. Katzmann, D. J., Odorizzi, G. and Emr, S. D. (2002) Receptor downregulation and multivesicular-body sorting. Nat. Rev. Mol. Cell Biol. 3, 893-905
4. Bouamr, F., Melillo, J. A., Wang, M. Q., Nagashima, K., de Los Santos, M., Rein, A. and Goff, S. P. (2003) PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101. J. Virol. 77, 11882-11895
5. + channel. J. Biol. Chem. 278, 20019-20028
6. Kanelis, V., Bruce, M. C., Skrynnikov, N. R., Rotin, D. and Forman-Kay, J. D. (2006) Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex. Structure 14, 543-553
7. Pak, Y., Glowacka, W. K., Bruce, M. C., Pham, N. and Rotin, D. (2006) Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J. Cell Biol. 175, 631-645
8. + channel deleted in Liddle's syndrome. EMBO J. 15, 2371-2380
9. Leykauf, K., Salek, M., Bomke, J., Frech, M., Lehmann, W. D., Durst, M. and Alonso, A. (2006) Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process. J. Cell Sci. 119, 3634-3642
10. Batt, J., Bain, J., Goncalves, J., Michalski, B., Plant, P., Fahnestock, M. and Woodgett, J. (2006) Differential gene expression profiling of short and long term denervated muscle. FASEB J. 20, 115-117
11. Koncarevic, A., Jackman, R. W. and Kandarian, S. C. (2007) The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension. FASEB J. 21, 427-437
12. Stevenson, E. J., Koncarevic, A., Giresi, P. G., Jackman, R. W. and Kandarian, S. C. (2005) Transcriptional profile of a myotube starvation model of atrophy. J. Appl. Physiol. 98, 1396-1406
13. Nandurkar, H. H. and Huysmans, R. (2002) The myotubularin family: novel phosphoinositide regulators. IUBMB Life 53, 37-43
14. Lorenzo, O., Urbe, S. and Clague, M. J. (2006) Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J. Cell Sci. 119, 2953-2959
15. Zhao, R., Qi, Y., Chen, J. and Zhao, Z. J. (2001) FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. Exp. Cell Res. 265, 329-338
16. Bain, J. R., Veltri, K. L., Chamberlain, D. and Fahnestock, M. (2001) Improved functional recovery of denervated skeletal muscle after temporary sensory nerve innervation. Neuroscience 103, 503-510
17. Hynes, N. M., Bain, J. R., Thoma, A., Veltri, K. and Maguire, J. A. (1997) Preservation of denervated muscle by sensory protection in rats. J. Reconstr. Microsurg. 13, 337-343
18. phox bind to lipid products of PI(3)K. Nat. Cell Biol. 3, 675-678
19. Kanelis, V., Rotin, D. and Forman-Kay, J. D. (2001) Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nat. Struct. Biol. 8, 407-412
20. Patterson, C. and Cyr, D. M. (eds) (2005) Ubiquitin-Proteasome Protocols (Methods in Molecular Biology, vol. 301), Springer, Berlin
21. 2+-dependent plasma membrane localization. J. Biol. Chem. 272, 32329-32336
22. Plant, P. J., Lafont, F., Lecat, S., Verkade, P., Simons, K. and Rotin, D. (2000) Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb. J. Cell Biol. 149, 1473-1484
23. Dunn, R. and Hicke, L. (2001) Domains of the Rsp5 ubiquitin-protein ligase required for receptor-mediated and fluid-phase endocytosis. Mol. Biol. Cell 12, 421-435
24. Dunn, R. and Hicke, L. (2001) Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis. J. Biol. Chem. 276, 25974-25981
25. Dunn, R., Klos, D. A., Adler, A. S. and Hicke, L. (2004) The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo. J. Cell Biol. 165, 135-144
26. Buj-Bello, A., Biancalana, V., Moutou, C., Laporte, J. and Mandel, J. L. (1999) Identification of novel mutations in the MTM1 gene causing severe and mild forms of X-linked myotubular myopathy. Hum. Mutat. 14, 320-325
27. Laporte, J., Biancalana, V., Tanner, S. M., Kress, W., Schneider, V., Wallgren-Pettersson, C., Herger, F., Buj-Bello, A., Blondeau, F., Liechti-Gallati, S. and Mandel, J. L. (2000) MTM1 mutations in X-linked myotubular myopathy. Hum. Mutat. 15, 393-409
28. Buj-Bello, A., Fougerousse, F., Schwab, Y., Messaddeq, N., Spehner, D., Pierson, C. R., Durand, M., Kretz, C., Danos, O., Douar, A. M. et al. (2008) AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis. Hum. Mol. Genet. 17, 2132-2143
29. Ma, J., Zeng, F., Ho, W. T., Teng, L., Li, Q., Fu, X. and Zhao, Z. J. (2008) Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans. J. Cell. Biochem. 104, 1843-1852
30. Robinson, F. L. and Dixon, J. E. (2006) Myotubularin phosphatases: policing 3-phosphoinositides. Trends Cell Biol. 16, 403-412
31. Simonsen, A., Wurmser, A. E., Emr, S. D. and Stenmark, H. (2001) The role of phosphoinositides in membrane transport. Curr. Opin. Cell Biol. 13, 485-492
32. Odorizzi, G., Babst, M. and Emr, S. D. (1998) Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Cell 95, 847-858
33. Laporte, J., Bedez, F., Bolino, A. and Mandel, J. L. (2003) Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases. Hum. Mol. Genet. 12, R285-R292