메뉴 건너뛰기




Volumn 50, Issue 3, 2009, Pages 1247-1254

Inhibition of corneal inflammation by the TLR4 antagonist eritoran tetrasodium (E5564)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; ERITORAN; LIPOPOLYSACCHARIDE; PLACEBO; PROTEIN MD 2; SILICON; TOBRAMYCIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; 2,3 BIS(PALMITOYLOXY) 2 PROPYL 1 PALMITOYLCYSTEINE; 2,3-BIS(PALMITOYLOXY)-2-PROPYL-1-PALMITOYLCYSTEINE; 3 O DECYL 2 DEOXY 6 O (2 DEOXY 3 O (3 METHOXYDECYL) 6 O METHYL 2 ((1 OXO 11 OCTADECENYL)AMINO) 4 O PHOSPHONOGLUCOPYRANOSYL) 2 ((1,3 DIOXOTETRADECYL)AMINO) 1 (DIHYDROXY PHOSPHATE)GLUCOPYRANOSE; 3-O-DECYL-2-DEOXY-6-O-(2-DEOXY-3-O-(3-METHOXYDECYL)-6-O-METHYL-2-((1-OXO-11-OCTADECENYL)AMINO)-4-O-PHOSPHONOGLUCOPYRANOSYL)-2-((1,3-DIOXOTETRADECYL)AMINO)-1-(DIHYDROXY PHOSPHATE)GLUCOPYRANOSE; CXCL1 CHEMOKINE; CXCL1 PROTEIN, MOUSE; CYSTEINE; DISACCHARIDE; DRUG DERIVATIVE; LIPOPROTEIN; LY96 PROTEIN, MOUSE; SUGAR PHOSPHATE; TOLL LIKE RECEPTOR;

EID: 62649164799     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2628     Document Type: Article
Times cited : (42)

References (44)
  • 1
    • 0037784221 scopus 로고    scopus 로고
    • Bacterial keratitis: Predisposing factors, clinical and microbiological review of 300 cases
    • Bourcier T, Thomas F, Borderie V, Chaumeil C, Laroche L. Bacterial keratitis: predisposing factors, clinical and microbiological review of 300 cases. Br J Ophthalmol. 2003;87:834-838.
    • (2003) Br J Ophthalmol , vol.87 , pp. 834-838
    • Bourcier, T.1    Thomas, F.2    Borderie, V.3    Chaumeil, C.4    Laroche, L.5
  • 2
    • 40449129810 scopus 로고    scopus 로고
    • Risk factors and causative organisms in microbial keratitis
    • Green M, Apel A, Stapleton F. Risk factors and causative organisms in microbial keratitis. Cornea. 2008;27:22-27.
    • (2008) Cornea , vol.27 , pp. 22-27
    • Green, M.1    Apel, A.2    Stapleton, F.3
  • 3
    • 34247281033 scopus 로고    scopus 로고
    • The epidemiology of contact lens related infiltrates
    • Stapleton F, Keay L, Jalbert I, Cole N. The epidemiology of contact lens related infiltrates. Optom Vis Sci. 2007;84:257-272.
    • (2007) Optom Vis Sci , vol.84 , pp. 257-272
    • Stapleton, F.1    Keay, L.2    Jalbert, I.3    Cole, N.4
  • 4
    • 34247104456 scopus 로고    scopus 로고
    • Predictive factors for corneal infiltrates with continuous wear of silicone hydrogel contact lenses
    • Szczotka-Flynn L, Debanne SM, Cheruvu VK, et al. Predictive factors for corneal infiltrates with continuous wear of silicone hydrogel contact lenses. Arch Ophthalmol. 2007;125:488-492.
    • (2007) Arch Ophthalmol , vol.125 , pp. 488-492
    • Szczotka-Flynn, L.1    Debanne, S.M.2    Cheruvu, V.K.3
  • 5
    • 0032885174 scopus 로고    scopus 로고
    • Contact lens-induced peripheral ulcers with extended wear of disposable hydrogel lenses: Histopathologic observations on the nature and type of corneal infiltrate
    • Holden BA, Reddy MK, Sankaridurg PR, et al. Contact lens-induced peripheral ulcers with extended wear of disposable hydrogel lenses: histopathologic observations on the nature and type of corneal infiltrate. Cornea. 1999;18:538-543.
    • (1999) Cornea , vol.18 , pp. 538-543
    • Holden, B.A.1    Reddy, M.K.2    Sankaridurg, P.R.3
  • 6
    • 14144254613 scopus 로고    scopus 로고
    • Microbial keratitis in prospective studies of extended wear with disposable hydrogel contact lenses
    • Holden BA, Sankaridurg PR, Sweeney DF, Stretton S, Naduvilath TJ, Rao GN. Microbial keratitis in prospective studies of extended wear with disposable hydrogel contact lenses. Cornea. 2005;24:156-161.
    • (2005) Cornea , vol.24 , pp. 156-161
    • Holden, B.A.1    Sankaridurg, P.R.2    Sweeney, D.F.3    Stretton, S.4    Naduvilath, T.J.5    Rao, G.N.6
  • 7
    • 29644445049 scopus 로고    scopus 로고
    • Microbial keratitis predisposing factors and morbidity
    • Keay L, Edwards K, Naduvilath T, et al. Microbial keratitis predisposing factors and morbidity. Ophthalmology. 2006;113:109-116.
    • (2006) Ophthalmology , vol.113 , pp. 109-116
    • Keay, L.1    Edwards, K.2    Naduvilath, T.3
  • 8
    • 13944271838 scopus 로고    scopus 로고
    • Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation
    • Johnson AC, Heinzel FP, Diaconu E, et al. Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Invest Ophthalmol Vis Sci. 2005;46:589-595.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 589-595
    • Johnson, A.C.1    Heinzel, F.P.2    Diaconu, E.3
  • 9
    • 0036293662 scopus 로고    scopus 로고
    • Regulation of endotoxininduced keratitis by PECAM-1, MIP-2, and toll-like receptor 4
    • Khatri S, Lass JH, Heinzel FP, et al. Regulation of endotoxininduced keratitis by PECAM-1, MIP-2, and toll-like receptor 4. Invest Ophthalmol Vis Sci. 2002;43:2278-2284.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2278-2284
    • Khatri, S.1    Lass, J.H.2    Heinzel, F.P.3
  • 10
    • 0033963480 scopus 로고    scopus 로고
    • Lipopolysaccharide entry in the damaged cornea and specific uptake by polymorphonuclear neutrophils
    • Schultz CL, Buret AG, Olson ME, Ceri H, Read RR, Morck DW. Lipopolysaccharide entry in the damaged cornea and specific uptake by polymorphonuclear neutrophils. Infect Immun. 2000;68:1731-1734.
    • (2000) Infect Immun , vol.68 , pp. 1731-1734
    • Schultz, C.L.1    Buret, A.G.2    Olson, M.E.3    Ceri, H.4    Read, R.R.5    Morck, D.W.6
  • 12
    • 33748077451 scopus 로고    scopus 로고
    • Staphylococcus aureusinduced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88
    • Sun Y, Hise AG, Kalsow CM, Pearlman E. Staphylococcus aureusinduced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Infect Immun. 2006;74:5325-5332.
    • (2006) Infect Immun , vol.74 , pp. 5325-5332
    • Sun, Y.1    Hise, A.G.2    Kalsow, C.M.3    Pearlman, E.4
  • 13
    • 77649144871 scopus 로고    scopus 로고
    • Signaling pathways downstream of pattern-recognition receptors and their cross talk
    • Lee MS, Kim YJ. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem. 2008;83:481-489.
    • (2008) Annu Rev Biochem , vol.83 , pp. 481-489
    • Lee, M.S.1    Kim, Y.J.2
  • 14
    • 1642529500 scopus 로고    scopus 로고
    • Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
    • Gioannini TL, Teghanemt A, Zhang D, et al. Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations. Proc Natl Acad Sci U S A. 2004;101:4186-4191.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4186-4191
    • Gioannini, T.L.1    Teghanemt, A.2    Zhang, D.3
  • 15
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007;7:353-364.
    • (2007) Nat Rev Immunol , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 16
    • 0035399615 scopus 로고    scopus 로고
    • Diphosphoryl lipid A from Rhodobacter sphaeroides blocks the binding and internalization of lipopolysaccharide in RAW 264.7 cells
    • Kutuzova GD, Albrecht RM, Erickson CM, Qureshi N. Diphosphoryl lipid A from Rhodobacter sphaeroides blocks the binding and internalization of lipopolysaccharide in RAW 264.7 cells. J Immunol. 2001;167:482-489.
    • (2001) J Immunol , vol.167 , pp. 482-489
    • Kutuzova, G.D.1    Albrecht, R.M.2    Erickson, C.M.3    Qureshi, N.4
  • 17
    • 0026088437 scopus 로고
    • Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes
    • Golenbock DT, Hampton RY, Qureshi N, Takayama K, Raetz CR. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J Biol Chem. 1991;266:19490-19498.
    • (1991) J Biol Chem , vol.266 , pp. 19490-19498
    • Golenbock, D.T.1    Hampton, R.Y.2    Qureshi, N.3    Takayama, K.4    Raetz, C.R.5
  • 18
    • 0026019704 scopus 로고
    • Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice
    • Qureshi N, Takayama K, Kurtz R. Diphosphoryl lipid A obtained from the nontoxic lipopolysaccharide of Rhodopseudomonas sphaeroides is an endotoxin antagonist in mice. Infect Immun. 1991;59:441-444.
    • (1991) Infect Immun , vol.59 , pp. 441-444
    • Qureshi, N.1    Takayama, K.2    Kurtz, R.3
  • 19
    • 18144425200 scopus 로고    scopus 로고
    • TLR4 antagonists for endotoxemia and beyond
    • Rossignol DP, Lynn M. TLR4 antagonists for endotoxemia and beyond. Curr Opin Investig Drugs. 2005;6:496-502.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 496-502
    • Rossignol, D.P.1    Lynn, M.2
  • 20
    • 3142713223 scopus 로고    scopus 로고
    • Inhibition of endotoxin response by synthetic TLR4 antagonists
    • Hawkins LD, Christ WJ, Rossignol DP. Inhibition of endotoxin response by synthetic TLR4 antagonists. Curr Top Med Chem. 2004;4:1147-1171.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1147-1171
    • Hawkins, L.D.1    Christ, W.J.2    Rossignol, D.P.3
  • 21
    • 0036954040 scopus 로고    scopus 로고
    • Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue
    • Rossignol DP, Lynn M. Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue. J Endotoxin Res. 2002;8:483-488.
    • (2002) J Endotoxin Res , vol.8 , pp. 483-488
    • Rossignol, D.P.1    Lynn, M.2
  • 24
    • 33846456617 scopus 로고    scopus 로고
    • A phase II, doubleblind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
    • Bennett-Guerrero E, Grocott HP, Levy JH, et al. A phase II, doubleblind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass. Anesth Analg. 2007;104:378-383.
    • (2007) Anesth Analg , vol.104 , pp. 378-383
    • Bennett-Guerrero, E.1    Grocott, H.P.2    Levy, J.H.3
  • 25
    • 3142742677 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers
    • Rossignol DP, Wasan KM, Choo E, et al. Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers. Antimicrob Agents Chemother. 2004;48:3233-3240.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3233-3240
    • Rossignol, D.P.1    Wasan, K.M.2    Choo, E.3
  • 26
    • 34548222514 scopus 로고    scopus 로고
    • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
    • Kim HM, Park BS, Kim JI, et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell. 2007;130:906-917.
    • (2007) Cell , vol.130 , pp. 906-917
    • Kim, H.M.1    Park, B.S.2    Kim, J.I.3
  • 27
    • 26844502584 scopus 로고    scopus 로고
    • Evaluation of a human corneal epithelial cell line as an in vitro model for assessing ocular irritation
    • Kruszewski FH, Walker TL, DiPasquale LC. Evaluation of a human corneal epithelial cell line as an in vitro model for assessing ocular irritation. Fundam Appl Toxicol. 1997;36:130-140.
    • (1997) Fundam Appl Toxicol , vol.36 , pp. 130-140
    • Kruszewski, F.H.1    Walker, T.L.2    DiPasquale, L.C.3
  • 28
    • 4344705045 scopus 로고    scopus 로고
    • Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium
    • Ueta M, Nochi T, Jang MH, et al. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004;173:3337-3347.
    • (2004) J Immunol , vol.173 , pp. 3337-3347
    • Ueta, M.1    Nochi, T.2    Jang, M.H.3
  • 29
    • 33847780897 scopus 로고    scopus 로고
    • CXCL1/KC and CXCL5/LIX are produced selectively by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis
    • Lin M, Carlson E, Diaconu E, Pearlman E. CXCL1/KC and CXCL5/LIX are produced selectively by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis. J Leukoc Biol. 2007;81(3):786-792.
    • (2007) J Leukoc Biol , vol.81 , Issue.3 , pp. 786-792
    • Lin, M.1    Carlson, E.2    Diaconu, E.3    Pearlman, E.4
  • 31
    • 33845428613 scopus 로고    scopus 로고
    • MD-2 expression is not required for cell surface targeting of Tolllike receptor 4 (TLR4)
    • Visintin A, Halmen KA, Khan N, Monks BG, Golenbock DT, Lien E. MD-2 expression is not required for cell surface targeting of Tolllike receptor 4 (TLR4). J Leukoc Biol. 2006;80:1584-1592.
    • (2006) J Leukoc Biol , vol.80 , pp. 1584-1592
    • Visintin, A.1    Halmen, K.A.2    Khan, N.3    Monks, B.G.4    Golenbock, D.T.5    Lien, E.6
  • 32
    • 33747178729 scopus 로고    scopus 로고
    • Inhibition of toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury
    • Shimamoto A, Chong AJ, Yada M, et al. Inhibition of toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury. Circulation. 2006;114:I270-I274.
    • (2006) Circulation , vol.114
    • Shimamoto, A.1    Chong, A.J.2    Yada, M.3
  • 33
    • 22644439562 scopus 로고    scopus 로고
    • Physiologic, biochemical, and imaging characterization of acute lung injury in mice
    • Zhou Z, Kozlowski J, Schuster DP. Physiologic, biochemical, and imaging characterization of acute lung injury in mice. Am J Respir Crit Care Med. 2005;172:344-351.
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 344-351
    • Zhou, Z.1    Kozlowski, J.2    Schuster, D.P.3
  • 34
    • 42949166405 scopus 로고    scopus 로고
    • MyD88 functions as a negative regulator of TLR3/TRIF induced corneal inflammation by inhibiting activation of c-jun n-terminal kinase (JNK)
    • Johnson AC, Li X, Pearlman E. MyD88 functions as a negative regulator of TLR3/TRIF induced corneal inflammation by inhibiting activation of c-jun n-terminal kinase (JNK). J Biol Chem. 2008;283(7):3988-3996.
    • (2008) J Biol Chem , vol.283 , Issue.7 , pp. 3988-3996
    • Johnson, A.C.1    Li, X.2    Pearlman, E.3
  • 35
    • 0141653750 scopus 로고    scopus 로고
    • Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin
    • Zhang J, Xu K, Ambati B, Yu FS. Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin. Invest Ophthalmol Vis Sci. 2003;44:4247-4254.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 4247-4254
    • Zhang, J.1    Xu, K.2    Ambati, B.3    Yu, F.S.4
  • 36
    • 33644826593 scopus 로고    scopus 로고
    • Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells
    • Kumar A, Zhang J, Yu FS. Toll-like receptor 3 agonist poly(I:C)-induced antiviral response in human corneal epithelial cells. Immunology. 2006;117:11-21.
    • (2006) Immunology , vol.117 , pp. 11-21
    • Kumar, A.1    Zhang, J.2    Yu, F.S.3
  • 37
    • 32244445123 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells
    • Kumar A, Zhang J, Yu FS. Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Microbes Infect. 2006;8:380-389.
    • (2006) Microbes Infect , vol.8 , pp. 380-389
    • Kumar, A.1    Zhang, J.2    Yu, F.S.3
  • 38
    • 0036301797 scopus 로고    scopus 로고
    • Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    • Nagai Y, Akashi S, Nagafuku M, et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol. 2002;3:667-672.
    • (2002) Nat Immunol , vol.3 , pp. 667-672
    • Nagai, Y.1    Akashi, S.2    Nagafuku, M.3
  • 39
    • 0037108521 scopus 로고    scopus 로고
    • Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice
    • Yang KK, Dorner BG, Merkel U, et al. Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice. J Immunol. 2002;169:4475-4480.
    • (2002) J Immunol , vol.169 , pp. 4475-4480
    • Yang, K.K.1    Dorner, B.G.2    Merkel, U.3
  • 40
    • 34249650685 scopus 로고    scopus 로고
    • E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes
    • Czeslick E, Struppert A, Simm A, Sablotzki A. E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes. Inflamm Res. 2006;55:511-515.
    • (2006) Inflamm Res , vol.55 , pp. 511-515
    • Czeslick, E.1    Struppert, A.2    Simm, A.3    Sablotzki, A.4
  • 41
    • 0034755007 scopus 로고    scopus 로고
    • The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells
    • Song PI, Abraham TA, Park Y, et al. The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest Ophthalmol Vis Sci. 2001;42:2867-2877.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 2867-2877
    • Song, P.I.1    Abraham, T.A.2    Park, Y.3
  • 42
    • 33644681806 scopus 로고    scopus 로고
    • LBP and CD14 secreted in tears by the lacrimal glands modulate the LPS response of corneal epithelial cells
    • Blais DR, Vascotto SG, Griffith M, Altosaar I. LBP and CD14 secreted in tears by the lacrimal glands modulate the LPS response of corneal epithelial cells. Invest Ophthalmol Vis Sci. 2005;46:4235-4244.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 4235-4244
    • Blais, D.R.1    Vascotto, S.G.2    Griffith, M.3    Altosaar, I.4
  • 44
    • 45949095358 scopus 로고    scopus 로고
    • Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide
    • Sun Y, Fox T, Adhikary G, Kester M, Pearlman E. Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J Leukoc Biol. 2008;83:1512-1521.
    • (2008) J Leukoc Biol , vol.83 , pp. 1512-1521
    • Sun, Y.1    Fox, T.2    Adhikary, G.3    Kester, M.4    Pearlman, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.