Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study

Atherosclerosis

Volumn 203, Issue 2, 2009, Pages 454-458

  Hulkkonen, Janne ^a   Lehtimäki, Terho ^a,b   Mononen, Nina ^a   Juonala, Markus ^c   Hutri Kähönen, Nina ^a,b   Taittonen, Leena ^d,e   Marniemi, Jukka ^f   Nieminen, Tuomo ^b   Viikari, Jorma ^c   Raitakari, Olli ^c   Kähönen, Mika ^a,b  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d VAASA CENTRAL HOSPITAL   (Finland)

^e UNIVERSITY OF OULU   (Finland)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Blood pressure; Compliance; Cytokine; HDL; Hypertension; Interleukin 6; Polymorphism

Indexed keywords

APOLIPOPROTEIN A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6;

ADULT; ALLELE; ARTERY COMPLIANCE; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CAROTID ARTERY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE MARKER; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HOMOZYGOSITY; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROMOTER REGION; SYSTOLIC BLOOD PRESSURE; ULTRASOUND;

ADULT; ALLELES; ATHEROSCLEROSIS; CYTOKINES; FEMALE; HOMOZYGOTE; HUMANS; INFLAMMATION; INTERLEUKIN-6; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK; RISK FACTORS; SEX FACTORS; YOUNG ADULT;

EID: 62649162325     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.07.014     Document Type: Article

References (36)

1. Fishman D., Faulds G., Jeffery R., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102 (1998) 1369-1376
2. Bonafe M., Olivieri F., Cavallone L., et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 31 (2001) 2357-2361
3. Kilpinen S., Hulkkonen J., Wang X.Y., and Hurme M. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. Eur Cytokine Netw 12 (2001) 62-68
4. Humphries S.E., Luong L.A., Ogg M.S., Hawe E., and Miller G.J. The interleukin-6-174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 22 (2001) 2243-2252
5. Hulkkonen J., Pertovaara M., Antonen J., Pasternack A., and Hurme M. Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjogren's syndrome and correlate with the clinical manifestations of the disease. Rheumatology (Oxford) 40 (2001) 656-661
6. Antonicelli R., Olivieri F., Bonafe M., et al. The interleukin-6-174 G > C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients. Int J Cardiol 103 (2005) 266-271
7. Sie M.P., Uitterlinden A.G., Bos M.J., et al. TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study. Stroke 37 (2006) 2667-2671
8. Georges J.L., Loukaci V., Poirier O., et al. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde. J Mol Med 79 (2001) 300-305
9. Basso F., Lowe G.D., Rumley A., McMahon A.D., and Humphries S.E. Interleukin-6-174G > C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS). Arterioscler Thromb Vasc Biol 22 (2002) 599-604
10. Sie M.P., Sayed-Tabatabaei F.A., Oei H.H., et al. Interleukin 6-174 g/c promoter polymorphism and risk of coronary heart disease: results from the Rotterdam study and a meta-analysis. Arterioscler Thromb Vasc Biol 26 (2006) 212-217
11. Hurme M., Lehtimäki T., Jylhä M., Karhunen P.J., and Hervonen A. Interleukin-6-174G/C polymorphism and longevity: a follow-up study. Mech Ageing Dev 126 (2005) 417-418
12. Blacher J., Pannier B., Guerin A.P., et al. Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. Hypertension 32 (1998) 570-574
13. Juonala M., Viikari J.S., Hutri-Kähönen N., et al. The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference. J Intern Med 255 (2004) 457-468
14. O'Leary D.H., Polak J.F., Kronmal R.A., et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340 (1999) 14-22
15. Oliver J.J., and Webb D.J. Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol 23 (2003) 554-566
16. Raitakari O.T., Juonala M., Kähönen M., et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA 290 (2003) 2277-2283
17. Yufu K., Takahashi N., Anan F., et al. Brachial arterial stiffness predicts coronary atherosclerosis in patients at risk for cardiovascular diseases. Jpn Heart J 45 (2004) 231-242
18. Burke G.L., Evans G.W., Riley W.A., et al. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke 26 (1995) 386-391
19. Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340 (1992) 1111-1115
20. Aggoun Y., Bonnet D., Sidi D., et al. Arterial mechanical changes in children with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 20 (2000) 2070-2075
21. Liang Y.L., Shiel L.M., Teede H., et al. Effects of blood pressure, smoking, and their interaction on carotid artery structure and function. Hypertension 37 (2001) 6-11
22. Tounian P., Aggoun Y., Dubern B., et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 358 (2001) 1400-1404
23. Åkerblom H.K., Viikari J., Uhari M., et al. Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children's and families' state of health. Acta Paediatr Scand Suppl 318 (1985) 49-63
24. Lehtimäki T., Moilanen T., Viikari J., et al. Apolipoprotein E phenotypes in Finnish youths: a cross-sectional and 6-year follow-up study. J Lipid Res 31 (1990) 487-495
25. Livak K.J. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 14 (1999) 143-149
26. Jenny N.S., Tracy R.P., Ogg M.S., et al. E: In the elderly, interleukin-6 plasma levels and the -174G > C polymorphism are associated with the development of cardiovascular disease. Arterioscler Thromb Vasc Biol 22 (2002) 2066-2071
27. Licastro F., Chiappelli M., Caldarera C.M., et al. The concomitant presence of polymorphic alleles of interleukin-1beta, interleukin-6 and apolipoprotein E is associated with an increased risk of myocardial infarction in elderly men. Results from a pilot study. Mech Ageing Dev 125 (2004) 575-579
28. Chiappelli M., Tampieri C., Tumini E., et al. Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. Int J Immunogenet 32 (2005) 349-353
29. Shifman S., and Darvasi A. The value of isolated populations. Nat Genet 28 (2001) 309-310
30. Peltonen L., Jalanko A., and Varilo T. Molecular genetics of the Finnish disease heritage. Hum Mol Genet 8 (1999) 1913-1923
31. Rauramaa R., Väisänen S.B., Luong L.A., et al. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler Thromb Vasc Biol 20 (2000) 2657-2662
32. Roman M.J., Moeller E., Davis A., et al. Preclinical carotid atherosclerosis in patients with rheumatoid arthritis. Ann Intern Med 144 (2006) 249-256
33. Fernandez-Real J.M., Broch M., Vendrell J., Richart C., and Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 85 (2000) 1334-1339
34. Metzger S., Hassin T., Barash V., Pappo O., and Chajek-Shaul T. Reduced body fat and increased hepatic lipid synthesis in mice bearing interleukin-6-secreting tumor. Am J Physiol Endocrinol Metab 281 (2001) E957-965
35. Kubaszek A., Pihlajamaki J., Punnonen K., et al. The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. Diabetes 52 (2003) 558-561
36. Rohrer L., Hersberger M., and von Eckardstein A. High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease. Curr Opin Lipidol 15 (2004) 269-278