Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk

Atherosclerosis

Volumn 203, Issue 2, 2009, Pages 346-352

  Consuegra Sanchez, Luciano ^a   Fredericks, Salim ^a,b   Kaski, Juan Carlos ^a  

^a Division of Cardiac and Vascular Sciences   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Atherosclerosis; PAPP A; Pro MBP

Indexed keywords

ANTITHROMBOCYTIC AGENT; ATORVASTATIN; CORN OIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; OMEGA 3 FATTY ACID; PREGNANCY ASSOCIATED PLASMA PROTEIN A; TROPONIN;

ACUTE CORONARY SYNDROME; ARTERY DISEASE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ARTERY DISEASE; CLINICAL PRACTICE; CLINICAL TRIAL; CORONARY ARTERY DISEASE; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE MARKER; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; REVIEW; STABLE ANGINA PECTORIS; UNSTABLE ANGINA PECTORIS;

ANGIOGRAPHY; ATHEROSCLEROSIS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CAROTID ARTERY DISEASES; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; DISEASE PROGRESSION; EOSINOPHIL MAJOR BASIC PROTEIN; FEMALE; HUMANS; MALE; PREGNANCY; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROGNOSIS; ROC CURVE;

EID: 62649135518     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.07.042     Document Type: Review

References (50)

1. Fuster V., Moreno P.R., Fayad Z.A., et al. Atherothrombosis and high-risk plaque. Part I. Evolving concepts. J Am Coll Cardiol 20 46 (2005) 937-954
2. Chester M.R., Chen L., Tousoulis D., et al. Differential progression of complex and smooth stenoses within the same coronary tree in men with stable coronary artery disease. J Am Coll Cardiol 25 (1995) 837-842
3. Chen L., Chester M.R., Crook R., et al. Differential progression of complex culprit stenoses in patients with stable and unstable angina pectoris. J Am Coll Cardiol 28 (1996) 597-603
4. Chester M.R., Chen L., and Kaski J.C. The natural history of unheralded complex coronary plaques. J Am Coll Cardiol 28 (1996) 604-608
5. Kaski J.C., Chester M.R., Chen L., et al. Rapid angiographic progression of coronary artery disease in patients with angina pectoris. The role of complex stenosis morphology. Circulation 92 (1995) 2058-2065
6. Kaski J.C., Chen L., and Chester M. Rapid angiographic progression of "target" and "nontarget" stenoses in patients awaiting coronary angioplasty. J Am Coll Cardiol 26 (1995) 416-421
7. Khosravi J., Diamandi A., Krishna R.G., et al. Pregnancy associated plasma protein-A: ultrasensitive immunoassay and determination in coronary heart disease. Clin Biochem 35 (2002) 531-538
8. Pinon P., and Kaski J.C. Inflammation, Atherosclerosis, and cardiovascular disease risk: PAPP-A, Lp-PLA2, and cystatin C. New insights or redundant information?. Rev Esp Cardiol 59 (2006) 247-258
9. Harrington S.C., Simari R.D., and Conover C.A. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 22 100 (2007) 1696-1702
10. Bayes-Genis A., Conover C.A., Overgaard M.T., et al. Pregnancy-associated plasma protein A as a marker of acute coronary syndromes. N Engl J Med 345 (2001) 1022-1029
11. Cosin-Sales J., Kaski J.C., Christiansen M., et al. Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris. Eur Heart J 26 (2005) 2093-2098
12. Cosin-Sales J., Christiansen M., Kaminski P., et al. Pregnancy-associated plasma protein A and its endogenous inhibitor, the proform of eosinophil major basic protein (proMBP), are related to complex stenosis morphology in patients with stable angina pectoris. Circulation 109 (2004) 1724-1728
13. Lund J., Qin Q.P., Ilva T., et al. Circulating pregnancy-associated plasma protein predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation 108 (2003) 1924-1926
14. Heeschen C., Dimmeler S., Hamm C.W., et al. Investigators CS. Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol 45 (2005) 229-237
15. Qin Q.P., Laitinen P., Majamaa-Voltti K., et al. Release patterns of pregnancy associated plasma protein A (PAPP-A) in patients with acute coronary syndromes. Scand Cardiovasc J 36 (2002) 358-361
16. Laursen L.S., Overgaard M.T., Soe R., et al. Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett 504 (2001) 36-40
17. Lawrence J.B., Oxvig C., Overgaard M.T., et al. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci USA 96 (1999) 3149-3153
18. Beaudeux J.L., Burc L., Imbert-Bismut F., et al. Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk. Arterioscler Thromb Vasc Biol 23 (2003) e7-10
19. Sangiorgi G., Mauriello A., Bonanno E., et al. Pregnancy-associated plasma protein-A is markedly expressed by monocyte-macrophage cells in vulnerable and ruptured carotid atherosclerotic plaques: a link between inflammation and cerebrovascular events. J Am Coll Cardiol 47 (2006) 2201-2211
20. Aso Y., Okumura K., Wakabayashi S., et al. Elevated pregnancy-associated plasma protein-A in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index. J Clin Endocrinol Metab 89 (2004) 5713-5717
21. Mueller T., Dieplinger B., Poelz W., et al. Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study. Clin Chem 52 (2006) 1096-1103
22. Consuegra-Sanchez L., Petrovic I., Cosin-Sales J., et al. Prognostic value of circulating pregnancy-associated plasma protein-A (PAPP-A) and proform of eosinophil major basic protein (pro-MBP) levels in patients with chronic stable angina pectoris. Clin Chim Acta 391 (2008) 18-23
23. Elesber A.A., Conover C.A., Denktas A.E., et al. Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina. Eur Heart J 27 (2006) 1678-1684
24. Stulc T., Malbohan I., Malik J., et al. Increased levels of pregnancy-associated plasma protein-A in patients with hypercholesterolemia: the effect of atorvastatin treatment. Am Heart J 146 (2003) E21
25. Aarsetøy H., Brügger-Andersen T., Hetland Ø., et al. Long term influence of regular intake of high dose n-3 fatty acids on CD40-ligand, pregnancy-associated plasma protein A and matrix metalloproteinase-9 following acute myocardial infarction. Thromb Haemost 95 (2006) 329-336
26. Elesber A.A., Lerman A., Denktas A.E., et al. Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department. Int J Cardiol 117 (2007) 365-369
27. Laterza O.F., Cameron S.J., Chappell D., et al. Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients. Clin Chim Acta 348 (2004) 163-169
28. Domínguez-Rodríguez A., Abreu-González P., García-González M., et al. Circulating pregnancy-associated plasma protein A is not an early marker of acute myocardial infarction. Clin Biochem 38 (2005) 180-182
29. Lund J., Qin Q.P., Ilva T., et al. Pregnancy-associated plasma protein A: a biomarker in acute ST-elevation myocardial infarction (STEMI). Ann Med 38 3 (2006) 221-228
30. Conti E., Carrozza C., Capoluongo E., et al. Insulin-like growth factor-1 as a vascular protective factor. Circulation 110 (2004) 2260-2265
31. Conti E., Volpe M., Carrozza C., et al. Pregnancy-associated plasma protein-A and acute coronary syndromes: cause or consequence?. J Am Coll Cardiol 46 (2005) 1583-1584
32. Bersinger N.A., Groome N., and Muttukrishna S. Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term. Eur J Endocrinol 147 (2002) 785-793
33. Crea F., and Andreotti F. Pregnancy associated plasma protein-A and coronary atherosclerosis: marker, friend or foe?. Eur Heart J 26 (2005) 2075-2076
34. Conover C.A., Harrington S.C., Bale L.K., et al. Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages. Am J Physiol Heart Circ Physiol 292 (2007) H994-H1000
35. Renier G., Clement I., Desfaits A.C., et al. Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production. Endocrinology 137 (1996) 4611-4618
36. Bayes-Genis A., Conover C.A., and Schwartz R.S. The insulin-like growth factor axis: a review of atherosclerosis and restenosis. Circ Res 86 (2000) 125-130
37. Conti E., Andreotti F., and Zuppi C. Pregnancy-associated plasma protein A as predictor of outcome in patients with suspected acute coronary syndromes. Circulation 109 (2004) e211-e212
38. Apple F.S., Wu A.H., Mair J., et al. Committee on standardization of markers of cardiac damage of the IFCC. Future biomarkers for detection of ischemia and risk stratification in acute coronary syndrome. Clin Chem 51 (2005) 810-824
39. Park S., Youn J.C., Shin D.J., et al. Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. Coronary Artery Dis 18 (2007) 417-422
40. Bayes-genis A., Schwartz R.S., Lewis D.A., et al. Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty. Arterioscler Thromb Vasc Biol 21 (2001) 335-341
41. Qin Q.P., Kokkala S., Lund J., et al. Immunoassays developed for pregnancy-associated plasma protein-A (PAPP-A) in pregnancy may not recognize PAPP-A in acute coronary syndromes. Clin Chem 52 (2006) 398-404
42. Fredericks S., Bertomeu-Gonzalez V., Petrovic I., et al. Comment on immunoassays developed for pregnancy-associated plasma protein-A (PAPP-A) in pregnancy may not recognize PAPP-A in acute coronary syndromes. Clin Chem 52 (2006) 1619-1620
43. Oxvig C., Sand O., Kristensen T., et al. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J Biol Chem 268 (1993) 12243-12246
44. Wald N.J., Watt H.C., and Hackshaw A.K. Integrated screening for Down's syndrome on the basis of tests performed during the first and second trimesters. N Engl J Med 12 341 (1999) 461-467
45. Qin Q.P., Kokkala S., Lund J., et al. Molecular distinction of circulating pregnancy-associated plasma protein A in myocardial infarction and pregnancy. Clin Chem 51 (2005) 75-83
46. Lauzurica R., Pastor C., Bayés B., et al. Pretransplant pregnancy-associated plasma protein-A as a predictor of chronic allograft nephropathy and posttransplant cardiovascular events. Transplantation 80 (2005) 1441-1446
47. Wittfooth S., Qin Q.P., Lund J., et al. Immunofluorometric point-of-care assays for the detection of acute coronary syndrome-related noncomplexed pregnancy-associated plasma protein A. Clin Chem 52 (2006) 1794-1801
48. Pepe M.S., Janes H., Longton G., et al. Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. Am J Epidemiol 159 (2004) 882-890
49. Cook N.R. Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation 115 (2007) 928-935
50. Cook N.R., Buring J.E., and Ridker P.M. The effect of including C-reactive protein in cardiovascular risk prediction models for women. Ann Intern Med 145 (2006) 21-29