Interplay among membrane properties, protein properties and operating conditions on protein fouling during normal-flow microfiltration

Journal of Membrane Science

Volumn 332, Issue 1-2, 2009, Pages 93-103

  Loh, ShyTyug ^a   Beuscher, Uwe ^b   Poddar, Tarun K ^b   Porter, Andrew G ^c   Wingard, J Mark ^c   Husson, Scott M ^c   Wickramasinghe, S Ranil ^a  

^a Engineering Research Center and Hydraulics Laboratory   (United States)

^b W L GORE AND ASSOCIATES   (United States)

^c AMRL   (United States)

Author keywords

Flux decline; Microfiltration; Normal flow; Protein fouling; Surface characterization

Indexed keywords

ATR FT-IR; BIO-PHARMACEUTICAL INDUSTRIES; BOUND PROTEINS; BOVINE-SERUM ALBUMINS; EQUILIBRIUM ADSORPTIONS; FEED PRESSURES; FEED STREAMS; FERMENTATION MEDIAS; FILTRATE VOLUMES; FLOW FILTRATIONS; FLUX DECLINE; MEMBRANE PORES; MEMBRANE PROPERTIES; NORMAL-FLOW; OPERATING CONDITIONS; PERMEATE FLUXES; PH VALUES; POLY-VINYL-PYRROLIDONE; POLY-VINYLIDENE FLUORIDES; POLYCARBONATE MEMBRANES; PROTEIN CONCENTRATIONS; PROTEIN FOULING; PTFE MEMBRANES; SURFACE CHARACTERIZATION; TEFLON AF;

ADSORPTION; BIOCHEMICAL ENGINEERING; BODY FLUIDS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; MEMBRANES; MICROFILTRATION; ORGANIC POLYMERS; POLYMER BLENDS; POLYTETRAFLUOROETHYLENES; POROUS MATERIALS; SURFACE PROPERTIES;

MEMBRANE FOULING;

BOVINE SERUM ALBUMIN; HEMOGLOBIN; POLITEF; POLYCARBONATE; POLYVINYL ALCOHOL; POLYVINYLIDENE FLUORIDE;

ARTICLE; BIOFOULING; INFRARED SPECTROSCOPY; MEMBRANE FILTER; MICROFILTRATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS;

EID: 62649132028     PISSN: 03767388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.memsci.2009.01.031     Document Type: Article

References (26)

1. van Reis R., and Zydney A.L. Review: bioprocess membrane technology. J. Membr. Sci. 297 (2007) 16
2. Bohonak D.M., and Zydney A.L. Compaction and permeability effects with virus filtration membranes. J. Membr. Sci. 254 (2005) 71
3. Hlavacek M., and Bouchet F. Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions. J. Membr. Sci. 82 (1993) 285
4. Ho C.-C., and Zydney A.L. Transmembrane pressure profiles during constant flux microfiltration of bovine serum albumin. J. Membr. Sci. 209 (2002) 363
5. Hermia J. Constant pressure blocking filtration laws - application to power-law non-Newtonian fluids. Trans. Inst. Chem. Eng. 60 (1982) 183
6. Velasco C., Ouammou M., Calvo J.I., and Hernández A. Protein fouling in microfiltration: deposition mechanism as a function of pressure for different pH. J. Colloid Interf. Sci. 266 (2003) 148
7. Tracey E.M., and Davis R.H. Protein fouling of track etched polycarbonate microfiltration membranes. J. Colloid Interf. Sci. 167 (1994) 104
8. Bowen W.R., and Gan Q. Properties of microfiltration membranes: flux loss during constant pressure permeation of bovine serum albumin. Biotechnol. Bioeng. 38 (1991) 688
9. Mueller J., and Davis R.H. Protein fouling of surface-modified polymeric microfiltration membranes. J. Membr. Sci. 116 (1996) 47
10. Güell C., and Davis R.H. Membrane fouling during microfiltration of protein mixtures. J. Membr. Sci. 119 (1996) 269
11. Ho C.-C., and Zydney A.L. Effect of membrane morphology on the initial rate of protein fouling during microfiltration. J. Membr. Sci. 155 (1999) 261
12. Ho C.-C., and Zydney A.L. A combined pore blockage and cake filtration model for protein fouling during microfiltration. J. Colloid Interf. Sci. 232 (2000) 389
13. Ho C.-C., and Zydney A.L. Protein fouling of asymmetric and composite membranes. Ind. Eng. Chem. Res. 40 (2001) 1412
14. Lettmann C., Möckel D., and Staude E. Permeation and tangential flow streaming potential measurements for electrokinetic characterization of track-etched microfiltration membranes. J. Membr. Sci. 159 (1999) 243
15. Boccaccio T., Bottino A., Capannelli G., and Piaggio P. Characterization of PVDF membranes by vibrational spectroscopy. J. Membr. Sci. 210 (2002) 315
16. Mansur H.S., Orefice R.L., and Mansur A.A.P. Characterization of poly(vinyl alcohol)/poly(ethylene glycol) hydrogels and PVA-derived hybrids by small angle X-ray scattering and FTIR spectroscopy. Polymer 45 (2004) 7193
17. Murphy B., Kirwan P., and McLoughlin P. Investigation of polymer-diffusant interactions using ATR-FTIR spectroscopy. Vib. Spectrosc. 33 (2003) 75
18. Dehaye F., Balanzat E., Ferain E., and Legras R. Chemical modifications induced in bisphenol A polycarbonate by swift heavy ions. Nucl. Instrum. Meth. B 209 (2003) 103
19. König U., Nitschke M., Pilz M., Simon F., Arnhold C., and Werner C. Stability and aging of plasma treated poly(tetrafluoroethylene) surfaces. Colloid Surface B 25 (2002) 313
20. Kim K.J., Fane A.G., Nystrom M., Pihlajamaki A., Bowen W.R., and Mukhtar H. Evaluation of electroosmosis and streaming potential for measurement of electric charges of polymeric membranes. J. Membr. Sci. 116 (1996) 149
21. Tang C.Y., Kwon Y.-N., and Leckie J.O. Probing the nano- and micro-scales of reverse osmosis membranes - a comprehensive characterization of physiochemical properties of uncoated and coated membranes by XPS, TEM, ATR-FTIR, and streaming potential measurements. J. Membr. Sci. 287 (2007) 146
22. Zimmerman R., Dukhin S., and Werner C. Electrokinetic measurements reveal interfacial charges at polymer films caused by simple electrolyte ions. J. Phys. Chem. B 105 (2001) 8544
23. Mita T. Thermotrophic behavior of proteins and acylated proteins in monolayers. Bull. Chem. Soc. Jpn. 62 (1989) 2299
24. Palecek S.P., and Zydney A.L. Intermolecular electrostatic interactions and their effect on flux and protein deposition during protein filtration. Biotechnol. Prog. 10 (1994) 207
25. Belfort G., Davis R.H., and Zydney A.L. Review: the behavior of suspensions and macromolecular solutions in crossflow microfiltration. J. Membr. Sci. 96 (1994) 1
26. Kelly S.T., and Zydney A.L. Mechanisms for BSA fouling during microfiltration. J. Membr. Sci. 107 (1995) 115