Antifungal and anticancer activities of a protein from the mushroom Cordyceps militaris

Korean Journal of Physiology and Pharmacology

Volumn 13, Issue 1, 2009, Pages 49-54

  Park, Byung Tae ^a   Na, Kwang Heum ^a   Jung, Eui Cha ^a   Park, Jae Wan ^a   Kim, Ha Hyung ^a  

^a Chung Ang University   (South Korea)

Author keywords

Antifungal activity; Cordyceps militaris; Cytotoxicity; Mushroom; Protease

Indexed keywords

2 DIETHYLAMINOETHANOL; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; BENZYLSULFONYL FLUORIDE; PROTEINASE; SEPHAROSE;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ANION EXCHANGE CHROMATOGRAPHY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASIA; BLADDER CANCER; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CHINESE MEDICINE; CONTROLLED STUDY; CORDYCEPS; CORDYCEPS MILITARIS; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; FRUITING BODY; FUNGUS GROWTH; FUSARIUM OXYSPORUM; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MUSHROOM; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; TEMPERATURE;

EID: 62649130744     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2009.13.1.49     Document Type: Article

References (21)

1. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
2. Cunningham KG, Manson W, Spring FS, Hutchinson SA. Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link. Nature 166: 949, 1950.
3. Hattori M, Isomura S, Yokoyama E, Ujita M, Hara A. Extracellular trypsin-like proteases produced by Corodyceps militaris. J Biosci Bioeng 100: 631-636, 2005.
4. Hong SY, Oh JE, Lee KH. In vitro antifungal activity and cytotoxicity of a novel membrane-active peptide. Antimicrob Agents Chemother 43: 1704-1707, 1999.
5. Joshi BN, Sainani MN, Bastawade KB, Gupta VS, Ranjekar PK. Cysteine protease inhibitor from pearl millet: a new class of antifungal protein. Biochem Biophys Res Commun 246: 362-387. 1998.
6. Jung EC, Kim KD, Bae CH, Kim JC, Kim DR, Kim HH. A mushroom lectin from ascomycete Cordyceps militaris. Biochim Biophys Acta-General Subjects 1770: 833-838, 2007.
7. Kim BS, Oh KT, Cho DH, Kim YJ, Koo WM, Kong KH, Kim HH. A sialic acid-binding lectin from the lugume Maackia faurier: comparison with lectins from M. amurensis. Plant Science 167: 1315-1321. 2004.
8. Kim JS, Sapkota K, Park SE, Choi BS, Kim S, Nguyen TH, Kim CS, Choi HS, Kim MK, Chun HS, Park Y, Kim SJ. A fibrinolytic enzyme from the medicinal mushroom Cordyceps militaris. J Microbiol 44: 622-631, 2006.
9. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
10. Li H, Matsunaga S, Fusetani N. Halicylindramides A-C. antifungal and cytotoxic depsipeptides from the marine sponge Halichondria cylindrata. J Med Chem 38: 338-343, 1995.
11. Lindequist U, Niedermeyer TH, Julich WD. The pharmacological potential of mushrooms. Evid Based Complement Alternat Med 2: 285-299, 2005.
12. Moreno AB, del Pozo AM, Borja M, Segundo BS. Activity of the antifungal protein from Aspergillus gigarteus against Botrytis cinerea. Phytopathology 93: 1344-1353. 2003.
13. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
14. Nagai PHK, Ng TB. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia: cells. Life Sciences 73: 3363-3374, 2003.
15. Nagai PHK, Zhao Z, Ng TB. Agrocybin, an antifungal peptide from the edible mushroom Agrocybe cylindracea. Peptides 26: 191-196. 2005.
16. Ng TB. Peptides and proteins from fungi. Peptides 25: 1055-1073. 2004.
17. St Leger RJ, Charnley AK, Cooper RM. Characterization of cuticle-degrading proteases produced by the entomopathogen Metarhizium anisopliae. Arch Biochem Biophys 253: 221-232. 1987.
18. Vernekar JV, Ghatge MS, Deshpande VV. Alkaline protease inhibitor: a novel class of antifungal proteins against phytopathogenic fungi. Biochem Biophys Res Commun 262: 702-727, 1999.
19. Watanabe N, Hattori M, Yokoyama E, Isomura S, Ujita M, Hara A. Entomogenous fungi that produce 2,6-pyridine dicarboxylic acid (dipicolinic acid). Biosci Bioeng 102: 365-368, 2006.
20. Yen YH, Li PL, Wang CL, Wang SL. An antifungal protease produced by Pseudomonas aeruginosa M-1001 with shrimp and crab shell powder as a carbon source. Enzyme Microb Technol 39: 311-317, 2006.
21. Yu R, Song L, Zhao Y, Bin W, Wang L, Zhan H, Wu Y, Ye W, Yao X. Isolation and biological properties of polysaccharide CPS-1 from cultured, Cordyceps militaris. Fitoterapia 75: 465-472. 2004.