Cerebral monoamine oxidase a inhibition in tobacco smokers confirmed with PET and [11C]befloxatone

Journal of Clinical Psychopharmacology

Volumn 29, Issue 1, 2009, Pages 86-88

  Leroy, Claire ^a,b,c   Bragulat, Veronique ^a,b,c   Berlin, Ivan ^d   Grégoire, Marie Claude ^e   Bottlaender, Michel ^e   Roumenov, Dimitri ^e   Dollé, Frédéric ^e   Bourgeois, Sandrine ^e   Penttilä, Jani ^a,b,c   Artiges, Eric ^a,b,c,f   Martinot, Jean Luc ^a,b,c   Trichard, Christian ^a,b,c,f  

^a INSERM   (France)

^b DIF   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^f Orsay Hospital   (France)

Author keywords

11C befloxatone; Monoamine oxidase A; Positron emission tomography; Smoking

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BEFLOXATONE; BEFLOXATONE C 11; CARBON 11; CIGARETTE SMOKE; UNCLASSIFIED DRUG; AMINE OXIDASE (FLAVIN CONTAINING); CARBON; MONOAMINE OXIDASE INHIBITOR; NICOTINE; NICOTINIC AGENT; OXAZOLE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ADULT; ARTICLE; BRAIN; CAUDATE NUCLEUS; CEREBELLUM; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; FRONTAL CORTEX; HUMAN; MALE; MOOD; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; SMOKING; THALAMUS; TOBACCO DEPENDENCE; BRAIN CORTEX; ENZYMOLOGY; METABOLISM; PATHOPHYSIOLOGY; SCINTISCANNING; TISSUE DISTRIBUTION;

ADULT; CARBON RADIOISOTOPES; CEREBRAL CORTEX; HUMANS; MALE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NICOTINE; NICOTINIC AGONISTS; OXAZOLES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SMOKING; TISSUE DISTRIBUTION;

EID: 62649118386     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e31819e98f     Document Type: Article

References (13)

1. Berlin I, Anthenelli RM. Monoamine oxidases and tobacco smoking. Int J Neuropsychopharmacol. 2001;4:33-42.
2. Lewis A, Miller JH, Lea RA. Monoamine oxidase and tobacco dependence. Neurotoxicology. 2007;28:182-195.
3. Fowler JS, Volkow ND, Wang GJ, et al. Brain monoamine oxidase A inhibition in cigarette smokers. Proc Natl Acad Sci U S A. 1996;93:14065-14069.
4. Bottlaender M, Dolle F, Guenther I, et al. Mapping the cerebral monoamine oxidase type A: positron emission tomography characterization of the reversible selective inhibitor [11C]befloxatone. J Pharmacol Exp Ther. 2003;305:467-473.
5. Dollé F, Valette H, Bramoulle Y, et al. Synthesis and in vivo imaging properties of [11C]befloxatone: a novel highly potent positron emission tomography ligand for mono-amine oxidase-A. Bioorg Med Chem Lett. 2003;13:1771-1775.
6. Logan J. Graphical analysis of PET data applied to reversible and irreversible tracers. Nucl Med Bio. 2000;27:661-670.
7. Guillem K, Vouillac C, Azar MR, et al. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. J Neurosci. 2005;25:8593-8600.
8. Villégier AS, Salomon L, Granon S, et al. Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine. Neuropsychopharmacology. 2006;31:1704-1713.
9. Guillem K, Vouillac C, Azar MR, et al. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. Eur J Neurosci. 2006;24:3532-3540.
10. Ginovart N, Meyer JH, Boovariwala A, et al. Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain. J Cereb Blood Flow Metab. 2006;26:330-344.
11. Meyer JH, Ginovart N, Boovariwala A, et al. Elevated monoamine oxidase A levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry. 2006;63:1209-1216.
12. Covey LS, Glassman AH, Stetner F. Major depression following smoking cessation. Am J Psychiatry. 1997;154:263-265.
13. Glassman AH, Covey LS, Stetner F, et al. Smoking cessation and the course of major depression: a follow-up study. Lancet. 2001;357:1929-1932.