Biological properties and medicinal use of saffron (Crocus sativus L.)

Acta Horticulturae

Volumn 739, Issue , 2007, Pages 339-345

  Abdullaev, F ^a  

^a INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

Author keywords

Anticancer effect; Antigenotoxic; Components of saffron; Cytotoxic activity; Natural agents

Indexed keywords

ANIMALIA; CROCUS; CROCUS SATIVUS;

EID: 62549166005     PISSN: 05677572     EISSN: None     Source Type: Book Series    
DOI: 10.17660/ActaHortic.2007.739.44     Document Type: Conference Paper

References (26)

1. Abdullaev, F. I. 2002. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L). Exp. Biol. Med. 227: 20.
2. Abdullaev, F. I. 2003. Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicology in vitro 17 (5-6) : 751.
3. Abdullaev, F. I. 2004. Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Det. Preven. 28 (6) : 426-432.
4. Abe, K. 1999. Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Res. 851 (1-2) : 287-289. (Pubitemid 30038160)
5. Abe, K and Saito, H. 2000. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother. Res. 14: 149-152.
6. Ahmad, A. S. 2005. Pharmacology. Biochem. Behavior. 81: 805-613.
7. Akhondzadeh, S. 2004. BMC Complement. Altern. Med., 4:12.
8. Daly, E. S. 1998. Protective effect of cysteine and vitamine E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rat. J. Pharm. Belg. 53: 87-93.
9. Escribano, J. 1996. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cell in vitro. Cancer Lett. 100: 23-30.
10. Fatehi, M., Rashidabady, T. and Fatehi-Hassanabad, Z. 2003, J. Ethnopharmacol. 84, 199.
11. Garcia-Olmo, D. C. 1999. Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.) : an experimental study in the rats. Nutr. Cancer 35 (2) : 120-126.
12. Hosseinzadeh, H. and Khosravan, V. 2002. Anticonvulsant effects aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch. Irn. Med. 5: 44-47. (Pubitemid 34591502)
13. Hosseinzadeh, H. and Younesi, H. 2002. Petal and stigma extracts of Crocus sativus L. have antinociceptive and anti-inflammatory effects in mice. BMC Pharmacol., 2, 7.
14. Martin, G. 2002. Evaluation of the developmental toxicity of crocetin on Xenopus Food Chem. Toxicol. 40 (7) : 959-964.
15. Morjani, H. 1990. Growth inhibition and induction of crythroid diferentiation activity by crocin, dimethylcrocetine and β-carotene on K-562 tumor cells. Anticancer Res. 10: 1398-1406.
16. Nadkarni, K. M. 1976. Crocus sativus, Nigella. p. 386-411. In: K. M. Nadkarni (ed.), Indian Materia Medica Popular Prakashan, Bombay.
17. Nair, S. C. 1991. Antitumor activity of saffron (Crocus sativus). Cancer Lett. 57 (2) : 109-114.
18. Nair, S. C., Panikkar, K. R. and Parathod, R. K. 1993. Protective effects of crocetin on bladder cytotoxicity induced by cyclophosphamide. Cancer Biother. 8: 339-43.
19. Nair, S. C. 1994. Effects of saffron on vitamin A levels and its antitumor activity on the growth of solid tumor in mice. Int. J. Pharmac. 32 (2) : 105-114.
20. Nair, S. C. 1995. Saffron chemoprevention in biology and medicine: a review. Cancer Biother. 10: 257-264.
21. Premkumar, K. 2003. Protective effects of saffron (Crocus sativus L.) on genotoxininduced oxidative stress in Swiss albino mice. Phytother Res. 17 (6) : 614-617.
22. Salomi, M. J. 1991. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr. Cancer 16 (1) : 67-72.
23. Sigiura, M., Saito, H. and Abe, K. 1995. Etanol extract of Crocus sativus L. antagonizes the inhibitory action of ethanol on hippocampal long-term potentiation in vivo. Phytother Res. 9: 100-104.
24. Tarantilis, P. A. 1994. Inhibition of growth and induction of differentiation promyelocytic leukemia (HL-60) by carotenoids from Crocus sativus L. 1Anticancer Res. 14:1913-1918.
25. Verma, S. K. and Bordia, A. 1998. Antioxidant property of saffron in man. Indian J. Med. Sci. 52 (5) : 205-207.
26. Xuan, B. 1999. Effects of crocin analogs on ocular flow and retinal function. J. Ocul. Pharmacol. Ther. 15 (2) : 143-52. (Pubitemid 29183585)