Non-myeloablative transplantation with CD8-depleted or unmanipulated peripheral blood stem cells: A phase II randomized trial

Leukemia

Volumn 23, Issue 3, 2009, Pages 608-610

  Willems, E ^a,b   Baron, F ^a,b   Baudoux, E ^a,b   Wanten, N ^a,b   Seidel, L ^a   Vanbellinghen, J F ^b   Herens, C ^b   Gothot, A ^a,b   Frere P ^a,b   Bonnet, C ^a,b   Hafraoui, K ^a,b   Vanstraelen, G ^c   Fillet, G ^a,b   Beguin, Y ^a,b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c Centre Hospitalier Peltzer La Tourelle   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; FLUDARABINE; HLA ANTIGEN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER RELAPSE; CD8+ T LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GRAFT VERSUS HOST REACTION; HLA MATCHING; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; MYELOPROLIFERATIVE DISORDER; NONHODGKIN LYMPHOMA; NONMYELOABLATIVE STEM CELL TRANSPLANTATION; PERIPHERAL BLOOD STEM CELL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REFRACTORY ANEMIA; REFRACTORY ANEMIA WITH EXCESS BLASTS; REFRACTORY ANEMIA WITH EXCESS BLASTS IN TRANSFORMATION; T CELL DEPLETION; WHOLE BODY RADIATION;

EID: 62549157826     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.248     Document Type: Article

References (8)

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2. Nimer SD, Giorgi J, Gajewski JL, Ku N, Schiller GJ, Lee K et al. Selective depletion of CD8+ cells for prevention of graft-versus-host disease after bone marrow transplantation. Transplantation 1994; 57: 82-87.
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4. Castermans E, Baron F, Willems E, Schaaf-Lafontaine N, Meuris N, Gothot A et al. Evidence for neo-generation of T cells by the thymus after non-myeloablative conditioning. Haematologica 2008; 93 240-247.
5. Kahl C, Storer BE, Sandmaier BM, Mielcarek M, Maris MB, Blume KG et al. Relapse risk in patients with malignant diseases given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. Blood 2007; 110: 2744-2748.
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7. + cells are associated with rapid T-cell engraftment and lessened risk of graft rejection, but not more graft-versus-host disease after nonmyeloablative conditioning and unrelated hematopoietic cell transplantation. Leukemia 2005; 19 822-828.
8. Panse JP, Heimfeld S, Guthrie KA, Maris MB, Maloney DG, Baril BB et al. Allogeneic peripheral blood stem cell graft composition affects early T-cell chimaerism and later clinical outcomes after nonmyeloablative conditioning. Br J Haematol 2005; 128: 659-667.