메뉴 건너뛰기




Volumn 58, Issue 2, 2009, Pages 55-65

Warfarin administration disrupts the assembly of mineralized nodules in the osteoid

Author keywords

Immunoelectron microscopy; Mineralization; Mineralized nodule; Osteoblast; Osteocalcin; Warfarin

Indexed keywords

ACID PHOSPHATASE; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALKALINE PHOSPHATASE; ISOENZYME; OSTEOCALCIN; TARTRATE-RESISTANT ACID PHOSPHATASE; WARFARIN;

EID: 62549148143     PISSN: 00220744     EISSN: 14779986     Source Type: Journal    
DOI: 10.1093/jmicro/dfp008     Document Type: Article
Times cited : (28)

References (55)
  • 1
    • 0005811867 scopus 로고
    • Direct identification of the calcium-binding amino acids, γ-carboxyglutamate, in mineralized tissue
    • Hauschika P V, Lian J B, and Gallop P M (1975) Direct identification of the calcium-binding amino acids, γ-carboxyglutamate, in mineralized tissue. Proc. Natl Acad. Sci. USA 72: 3925-3929.
    • (1975) Proc. Natl Acad. Sci. USA , vol.72 , pp. 3925-3929
    • Hauschika, P.V.1    Lian, J.B.2    Gallop, P.M.3
  • 3
    • 0008515619 scopus 로고
    • Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma
    • Price P A, and Nishimoto S K (1980) Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma. Proc. Natl Acad. Sci. USA 77: 2234-2238.
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 2234-2238
    • Price, P.A.1    Nishimoto, S.K.2
  • 4
    • 0019978329 scopus 로고
    • Calcium-dependent alpha-helical structure in osteocalcin
    • Hauschka P V and Carr S A (1982) Calcium-dependent alpha-helical structure in osteocalcin. Biochemistry 21: 2538-2547.
    • (1982) Biochemistry , vol.21 , pp. 2538-2547
    • Hauschka, P.V.1    Carr, S.A.2
  • 5
    • 0022413781 scopus 로고
    • Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein
    • Price P A, and Williamson M K (1985) Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. J. Biol. Chem. 260: 14971-14975.
    • (1985) J. Biol. Chem , vol.260 , pp. 14971-14975
    • Price, P.A.1    Williamson, M.K.2
  • 6
    • 0027940647 scopus 로고
    • Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely γ-carboxylated in humans
    • Cairns J R, and Price P A (1994) Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely γ-carboxylated in humans. J. Bone Miner. Res. 9: 1989-1997.
    • (1994) J. Bone Miner. Res , vol.9 , pp. 1989-1997
    • Cairns, J.R.1    Price, P.A.2
  • 7
    • 0343737341 scopus 로고
    • Vitamin K
    • Machlin L J ed, Dekker, New York
    • Suttie J W (1984) Vitamin K. In: Machlin L J (ed.), Handbook of Vitamins, pp 147-198 (Dekker, New York).
    • (1984) Handbook of Vitamins , pp. 147-198
    • Suttie, J.W.1
  • 8
    • 0023835095 scopus 로고
    • Osteocalcin. Biochemical consideration and clinical applications
    • Lian J B, and Gundberg C M (1988) Osteocalcin. Biochemical consideration and clinical applications. Clin. Orthop. 226: 267-291.
    • (1988) Clin. Orthop , vol.226 , pp. 267-291
    • Lian, J.B.1    Gundberg, C.M.2
  • 10
    • 0027384240 scopus 로고
    • Osteopenia and bone-remodeling abnormalities in warfarin-treated lambs
    • Pastoureau P, Vergnaud P, Meunier P J, and Delmas P D (1993) Osteopenia and bone-remodeling abnormalities in warfarin-treated lambs. J. Bone Miner. Res. 8: 1417-1426.
    • (1993) J. Bone Miner. Res , vol.8 , pp. 1417-1426
    • Pastoureau, P.1    Vergnaud, P.2    Meunier, P.J.3    Delmas, P.D.4
  • 11
    • 0037082374 scopus 로고    scopus 로고
    • Long-term treatment with sodium warfarin results in decreased femoral bone strength and cancellous bone volume in rats
    • Simon R R, Beaudin S M, Johnston M, Walton K J, and Shaughnessy S G (2002) Long-term treatment with sodium warfarin results in decreased femoral bone strength and cancellous bone volume in rats. Thromb. Res. 105: 353-358.
    • (2002) Thromb. Res , vol.105 , pp. 353-358
    • Simon, R.R.1    Beaudin, S.M.2    Johnston, M.3    Walton, K.J.4    Shaughnessy, S.G.5
  • 12
    • 0020361205 scopus 로고
    • Excessive mineralization with growth plate closure in rats on chronic warfarin treatment
    • Price P A, Williamson M K, Haba T, Dell R B and Jee W S (1982) Excessive mineralization with growth plate closure in rats on chronic warfarin treatment. Proc. Natl Acad. Sci. USA 79(24): 7734-7738.
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , Issue.24 , pp. 7734-7738
    • Price, P.A.1    Williamson, M.K.2    Haba, T.3    Dell, R.B.4    Jee, W.S.5
  • 13
    • 0020582824 scopus 로고
    • Concurrent warfarin treatment further reduced bone mineral levels in 1,25-dihydroxyvitamin D3-treated rats
    • Price P A, and Sloper S A (1983) Concurrent warfarin treatment further reduced bone mineral levels in 1,25-dihydroxyvitamin D3-treated rats. J. Biol. Chem. 258: 6004-6007.
    • (1983) J. Biol. Chem , vol.258 , pp. 6004-6007
    • Price, P.A.1    Sloper, S.A.2
  • 14
    • 0034011621 scopus 로고    scopus 로고
    • Diet- or warfarin-induced vitamin K insufficiency elevates circulating undercarboxylated osteocalcin without altering skeletal status in growing female rats
    • Haffa A, Krueger D, Bruner J, Engelke J, Gundberg C, Akhter M, and Binkley N (2000) Diet- or warfarin-induced vitamin K insufficiency elevates circulating undercarboxylated osteocalcin without altering skeletal status in growing female rats. J. Bone Miner. Res. 15(5): 872-878.
    • (2000) J. Bone Miner. Res , vol.15 , Issue.5 , pp. 872-878
    • Haffa, A.1    Krueger, D.2    Bruner, J.3    Engelke, J.4    Gundberg, C.5    Akhter, M.6    Binkley, N.7
  • 15
    • 0019772303 scopus 로고
    • Effects of warfarin on bone. Studies on vitamin K-dependent protein of rat bone
    • Price P A, and Willamson M K (1981) Effects of warfarin on bone. Studies on vitamin K-dependent protein of rat bone. J. Biol. Chem. 256: 12754-12759.
    • (1981) J. Biol. Chem , vol.256 , pp. 12754-12759
    • Price, P.A.1    Willamson, M.K.2
  • 16
    • 0026432629 scopus 로고
    • Oral anticoagulant drugs
    • Hirsh J (1991) Oral anticoagulant drugs. N. Engl. J. Med. 324: 1865-1875.
    • (1991) N. Engl. J. Med , vol.324 , pp. 1865-1875
    • Hirsh, J.1
  • 17
    • 0024490764 scopus 로고
    • Hemorrhagic complications of long-term anticoagulant therapy
    • Levine M N, Raskob G, and Hirsh J (1989) Hemorrhagic complications of long-term anticoagulant therapy. Chest 95: 26S-36S.
    • (1989) Chest , vol.95
    • Levine, M.N.1    Raskob, G.2    Hirsh, J.3
  • 18
    • 0024316072 scopus 로고
    • Major bleeding in outpatients treated with warfarin: Incidence and prediction by factors known at the start of out patient therapy
    • Landefeld C S, and Goldman L (1989) Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of out patient therapy. Am. J. Med. 87: 144-152.
    • (1989) Am. J. Med , vol.87 , pp. 144-152
    • Landefeld, C.S.1    Goldman, L.2
  • 19
    • 0018916729 scopus 로고
    • Maternal and fetal sequelae of anti-coagulation during pregnancy
    • Hall J G, Pauli R M, and Wilson K M (1980) Maternal and fetal sequelae of anti-coagulation during pregnancy. Am. J. Med. 68: 122-140.
    • (1980) Am. J. Med , vol.68 , pp. 122-140
    • Hall, J.G.1    Pauli, R.M.2    Wilson, K.M.3
  • 20
    • 0023609775 scopus 로고
    • Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: Cues to the mechanism of teratogenicity of coumarin derivatives
    • Pauli R M, Lian J B, Mosher D F, and Suttie J W (1987) Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: cues to the mechanism of teratogenicity of coumarin derivatives. Am. J. Hum. Genet. 41: 566-583.
    • (1987) Am. J. Hum. Genet , vol.41 , pp. 566-583
    • Pauli, R.M.1    Lian, J.B.2    Mosher, D.F.3    Suttie, J.W.4
  • 21
    • 0025350223 scopus 로고
    • Reduced axial bone mineral content in patients taking an oral anticoagulant
    • Fiore C E, Tamburino C, Foti R, and Grimaldi D (1990) Reduced axial bone mineral content in patients taking an oral anticoagulant. S. Med. J. 83(5): 538-542.
    • (1990) S. Med. J , vol.83 , Issue.5 , pp. 538-542
    • Fiore, C.E.1    Tamburino, C.2    Foti, R.3    Grimaldi, D.4
  • 22
    • 0025891741 scopus 로고
    • Decreased peripheral bone mineral content in patients under anticoagulant therapy with phenprocoumon
    • Resch H, Pietschmann P, Krexner E, and Willvonseder R (1991) Decreased peripheral bone mineral content in patients under anticoagulant therapy with phenprocoumon. Eur. Heart J. 12(3): 439-441.
    • (1991) Eur. Heart J , vol.12 , Issue.3 , pp. 439-441
    • Resch, H.1    Pietschmann, P.2    Krexner, E.3    Willvonseder, R.4
  • 23
    • 9544243083 scopus 로고
    • Heparins, coumarin, and bone density
    • Monreal M, Olive A, Lafoz E, and del Rio L (1991) Heparins, coumarin, and bone density. Lancet 338(8768): 706.
    • (1991) Lancet , vol.338 , Issue.8768 , pp. 706
    • Monreal, M.1    Olive, A.2    Lafoz, E.3    del Rio, L.4
  • 24
    • 0029088628 scopus 로고
    • Decreased axial and peripheral bone density in patients taking long-term warfarin
    • Philip W J, Martin J C, Richardson J M, Reid D M, Webster J, and Douglas A S (1995) Decreased axial and peripheral bone density in patients taking long-term warfarin. Q JM 88(9): 635-640.
    • (1995) Q JM , vol.88 , Issue.9 , pp. 635-640
    • Philip, W.J.1    Martin, J.C.2    Richardson, J.M.3    Reid, D.M.4    Webster, J.5    Douglas, A.S.6
  • 25
    • 0031456520 scopus 로고    scopus 로고
    • Long-term oral anticoagulation reduces bone mass in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation
    • Sato Y, Honda Y, Kunoh H, and Oizumi K (1997) Long-term oral anticoagulation reduces bone mass in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation. Stroke 28(12): 2390-2394.
    • (1997) Stroke , vol.28 , Issue.12 , pp. 2390-2394
    • Sato, Y.1    Honda, Y.2    Kunoh, H.3    Oizumi, K.4
  • 26
    • 0033598090 scopus 로고    scopus 로고
    • Caraballo P J, Heit J A, Atkinson E J, Silverstein M D, O'Fallon W M, Castro M R, and Melton L J 3rd (1999) Long-term use of oral anticoagulants and the risk of fracture. Arch. Intern. Med. 159(15): 1750-1756.
    • Caraballo P J, Heit J A, Atkinson E J, Silverstein M D, O'Fallon W M, Castro M R, and Melton L J 3rd (1999) Long-term use of oral anticoagulants and the risk of fracture. Arch. Intern. Med. 159(15): 1750-1756.
  • 27
    • 0019994317 scopus 로고
    • Normal cortical bone mass in patients after long term coumadin therapy
    • Piro L D, Whyte M P, Murphy W A, and Birge S J (1982) Normal cortical bone mass in patients after long term coumadin therapy. J. Clin. Endocrinol. Metab. 54(2): 470-473.
    • (1982) J. Clin. Endocrinol. Metab , vol.54 , Issue.2 , pp. 470-473
    • Piro, L.D.1    Whyte, M.P.2    Murphy, W.A.3    Birge, S.J.4
  • 30
    • 0032524129 scopus 로고    scopus 로고
    • Warfarin use and risk for osteoporosis in elderly women. Study of osteoporotic fractures research group
    • Jamal S A, Browner W S, Bauer D C, and Cummings S R (1998) Warfarin use and risk for osteoporosis in elderly women. Study of osteoporotic fractures research group. Ann. Intern. Med. 128(10): 829-832.
    • (1998) Ann. Intern. Med , vol.128 , Issue.10 , pp. 829-832
    • Jamal, S.A.1    Browner, W.S.2    Bauer, D.C.3    Cummings, S.R.4
  • 31
    • 0016788336 scopus 로고
    • Calcification of rachitic rat cartilage in vitro by extracellular matrix vesicles
    • Anderson H C, Cecil R, and Sajdera S W (1975) Calcification of rachitic rat cartilage in vitro by extracellular matrix vesicles. Am. J. Pathol. 79: 237-254.
    • (1975) Am. J. Pathol , vol.79 , pp. 237-254
    • Anderson, H.C.1    Cecil, R.2    Sajdera, S.W.3
  • 32
    • 0029061758 scopus 로고
    • Molecular biology of matrix vesicles
    • Anderson H C (1995) Molecular biology of matrix vesicles. Clin. Orthop. 314: 266-280.
    • (1995) Clin. Orthop , vol.314 , pp. 266-280
    • Anderson, H.C.1
  • 33
    • 0141560730 scopus 로고    scopus 로고
    • Matrix vesicles and calcification
    • Anderson H C (2003) Matrix vesicles and calcification. Curr. Rheumatol. Rep. 5: 222-226.
    • (2003) Curr. Rheumatol. Rep , vol.5 , pp. 222-226
    • Anderson, H.C.1
  • 34
    • 0035145179 scopus 로고    scopus 로고
    • Localizational alterations of calcium, phosphorus, and calcification-related organics such as proteoglycans and alkaline phosphatase during bone calcification
    • Hoshi K, Ejiri S, and Ozawa H (2001) Localizational alterations of calcium, phosphorus, and calcification-related organics such as proteoglycans and alkaline phosphatase during bone calcification. J. Bone Miner. Res. 16: 289-298.
    • (2001) J. Bone Miner. Res , vol.16 , pp. 289-298
    • Hoshi, K.1    Ejiri, S.2    Ozawa, H.3
  • 35
    • 40949123974 scopus 로고    scopus 로고
    • Current concepts of bone biomineralization
    • Ozawa H, Hoshi K, and Amizuka N (2008) Current concepts of bone biomineralization. J. Oral Sci. 50(1): 1-14.
    • (2008) J. Oral Sci , vol.50 , Issue.1 , pp. 1-14
    • Ozawa, H.1    Hoshi, K.2    Amizuka, N.3
  • 36
    • 0242499504 scopus 로고    scopus 로고
    • Bone recognition mechanism of porcine osteocalcin from crystal structure
    • Hoang Q Q, Sicheri F, Howard A J, and Yang D S (2003) Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature 425: 977-980.
    • (2003) Nature , vol.425 , pp. 977-980
    • Hoang, Q.Q.1    Sicheri, F.2    Howard, A.J.3    Yang, D.S.4
  • 37
    • 24044479401 scopus 로고    scopus 로고
    • Comparison of inhibitory effects of warfarin on gamma-carboxylation between bone and liver in rats
    • Hara K, Kobayashi M, and Akiyama Y (2005) Comparison of inhibitory effects of warfarin on gamma-carboxylation between bone and liver in rats. J. Bone Miner. Metab. 23(5): 366-372.
    • (2005) J. Bone Miner. Metab , vol.23 , Issue.5 , pp. 366-372
    • Hara, K.1    Kobayashi, M.2    Akiyama, Y.3
  • 38
    • 0027968182 scopus 로고
    • Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation
    • Amizuka N, Warshawsky H, Henderson J E, Goltzman D, and Karaplis A C (1994) Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation. J. Cell Biol. 126(6): 1611-1623.
    • (1994) J. Cell Biol , vol.126 , Issue.6 , pp. 1611-1623
    • Amizuka, N.1    Warshawsky, H.2    Henderson, J.E.3    Goltzman, D.4    Karaplis, A.C.5
  • 39
    • 0032706573 scopus 로고    scopus 로고
    • A general method for rapid purification of soluble versions of glycosylphosphatidylinositol-anchored proteins expressed in insect cells: An application for human tissue-nonspecific alkaline phosphatase
    • Oda K, Amaya Y, Fukushi-Irie M, Kinameri Y, Ohsuye K, Kubota I, Fujimura S, and Kobayashi J (1999) A general method for rapid purification of soluble versions of glycosylphosphatidylinositol-anchored proteins expressed in insect cells: an application for human tissue-nonspecific alkaline phosphatase. J. Biochem. 126: 694-699.
    • (1999) J. Biochem , vol.126 , pp. 694-699
    • Oda, K.1    Amaya, Y.2    Fukushi-Irie, M.3    Kinameri, Y.4    Ohsuye, K.5    Kubota, I.6    Fujimura, S.7    Kobayashi, J.8
  • 40
    • 0344450755 scopus 로고    scopus 로고
    • Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage
    • Amizuka N, Kwan M Y, Goltzman D, Ozawa H, and White J H (1999) Vitamin D3 differentially regulates parathyroid hormone/parathyroid hormone-related peptide receptor expression in bone and cartilage. J. Clin. Invest. 103: 373-381.
    • (1999) J. Clin. Invest , vol.103 , pp. 373-381
    • Amizuka, N.1    Kwan, M.Y.2    Goltzman, D.3    Ozawa, H.4    White, J.H.5
  • 41
    • 5344238901 scopus 로고    scopus 로고
    • Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats
    • Asawa Y, Amizuka N, Hara K, Kobayashi M, Aita M, Li M, Kenmotsu S, Oda K, Akiyama Y, and Ozawa H (2004) Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats. Bone 35: 870-880.
    • (2004) Bone , vol.35 , pp. 870-880
    • Asawa, Y.1    Amizuka, N.2    Hara, K.3    Kobayashi, M.4    Aita, M.5    Li, M.6    Kenmotsu, S.7    Oda, K.8    Akiyama, Y.9    Ozawa, H.10
  • 42
    • 9944241948 scopus 로고    scopus 로고
    • Appearance of electron-dense segments: Indication of possible conformational changes of pre-mineralizing collagen fibrils in the osteoid of rat bones
    • Asawa Y, Aoki K, Ohya K, Ohshima H, and Takano Y (2004) Appearance of electron-dense segments: indication of possible conformational changes of pre-mineralizing collagen fibrils in the osteoid of rat bones. J. Electron Microsc. 53: 423-433.
    • (2004) J. Electron Microsc , vol.53 , pp. 423-433
    • Asawa, Y.1    Aoki, K.2    Ohya, K.3    Ohshima, H.4    Takano, Y.5
  • 43
    • 0034054787 scopus 로고    scopus 로고
    • Differential involvement of matrix vesicles during the initial and appositional mineralization processes in bone, dentin, and cementum
    • Takano Y, Sakai H, Baba O, and Terashima T (2000) Differential involvement of matrix vesicles during the initial and appositional mineralization processes in bone, dentin, and cementum. Bone 26: 333-339.
    • (2000) Bone , vol.26 , pp. 333-339
    • Takano, Y.1    Sakai, H.2    Baba, O.3    Terashima, T.4
  • 44
    • 0036794941 scopus 로고    scopus 로고
    • Unique alignment and texture of biological apatite crystallites in typical calcified tissues analyzed by microbeam X-ray diffractometer system
    • Nakano T, Kaibara K, Tabata Y, Nagata N, Enomoto S, Marukawa E, and Umakoshi Y (2002) Unique alignment and texture of biological apatite crystallites in typical calcified tissues analyzed by microbeam X-ray diffractometer system. Bone 31: 479-487.
    • (2002) Bone , vol.31 , pp. 479-487
    • Nakano, T.1    Kaibara, K.2    Tabata, Y.3    Nagata, N.4    Enomoto, S.5    Marukawa, E.6    Umakoshi, Y.7
  • 45
    • 0035076239 scopus 로고    scopus 로고
    • Organic components of crystal sheaths in bones
    • Hoshi K, Ejiri S, and Ozawa H (2001) Organic components of crystal sheaths in bones. J. Electron Microsc. 50: 33-40.
    • (2001) J. Electron Microsc , vol.50 , pp. 33-40
    • Hoshi, K.1    Ejiri, S.2    Ozawa, H.3
  • 46
    • 0036364509 scopus 로고    scopus 로고
    • Crystal ghosts and biological mineralization: Fancy spectres in an old castle, or neglected structures worthy of belief
    • Bonucci E (2002) Crystal ghosts and biological mineralization: fancy spectres in an old castle, or neglected structures worthy of belief. J. Bone Miner. Metab. 20: 249-265.
    • (2002) J. Bone Miner. Metab , vol.20 , pp. 249-265
    • Bonucci, E.1
  • 47
    • 0029977717 scopus 로고    scopus 로고
    • Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins
    • Hunter G K, Hauschka P V, Poole A R, Rosenberg L C, and Goldberg H A (1996) Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. Biochem. J. 317: 59-64.
    • (1996) Biochem. J , vol.317 , pp. 59-64
    • Hunter, G.K.1    Hauschka, P.V.2    Poole, A.R.3    Rosenberg, L.C.4    Goldberg, H.A.5
  • 48
    • 0035857351 scopus 로고    scopus 로고
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285: 785-795.
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy (2001) Osteoporosis prevention, diagnosis, and therapy. JAMA 285: 785-795.
  • 49
    • 0031572274 scopus 로고    scopus 로고
    • Characterization of the complex between bovine osteocalcin and type I collagen
    • Prigodich R V, and Vesely M R (1997) Characterization of the complex between bovine osteocalcin and type I collagen. Arch. Biochem. Biophys. 345(2): 339-341.
    • (1997) Arch. Biochem. Biophys , vol.345 , Issue.2 , pp. 339-341
    • Prigodich, R.V.1    Vesely, M.R.2
  • 50
    • 0036342909 scopus 로고    scopus 로고
    • Hellmich C h, and Ulm F J (2002) Are mineralized tissues open crystal foams reinforced by crosslinked collagen? Some energy arguments. J. Biomech. 35(9): 1199-1212.
    • Hellmich C h, and Ulm F J (2002) Are mineralized tissues open crystal foams reinforced by crosslinked collagen? Some energy arguments. J. Biomech. 35(9): 1199-1212.
  • 51
    • 0024227764 scopus 로고
    • Mechanism of bone and cartilage maldevelopment in the warfarin embryopathy
    • Pauli R M (1988) Mechanism of bone and cartilage maldevelopment in the warfarin embryopathy. Pathol. Immunopathol. Res. 7(1-2): 107-112.
    • (1988) Pathol. Immunopathol. Res , vol.7 , Issue.1-2 , pp. 107-112
    • Pauli, R.M.1
  • 52
    • 0027185360 scopus 로고
    • Warfarin embryopathy: Patient, possibility, pathogenesis and prognosis
    • de Vries T W, Van Der Veer E, and Heijmans H S (1993) Warfarin embryopathy: patient, possibility, pathogenesis and prognosis. Br. J. Obstet. Gynaecol. 100(9): 869-871.
    • (1993) Br. J. Obstet. Gynaecol , vol.100 , Issue.9 , pp. 869-871
    • de Vries, T.W.1    Van Der Veer, E.2    Heijmans, H.S.3
  • 53
    • 0025157930 scopus 로고
    • Effect of sodium warfarin on vitamin K-dependent proteins and skeletal development in the rat fetus
    • Feteih R, Tassinari M S, and Lian J B (1990) Effect of sodium warfarin on vitamin K-dependent proteins and skeletal development in the rat fetus. J. Bone Miner. Res. 5(8): 885-894.
    • (1990) J. Bone Miner. Res , vol.5 , Issue.8 , pp. 885-894
    • Feteih, R.1    Tassinari, M.S.2    Lian, J.B.3
  • 54
    • 0030947025 scopus 로고    scopus 로고
    • Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    • Luo G, Ducy P, McKee M D, Pinero G J, Loyer E, Behringer R R, and Karsenty G (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386(6620): 78-81.
    • (1997) Nature , vol.386 , Issue.6620 , pp. 78-81
    • Luo, G.1    Ducy, P.2    McKee, M.D.3    Pinero, G.J.4    Loyer, E.5    Behringer, R.R.6    Karsenty, G.7
  • 55
    • 0033615970 scopus 로고    scopus 로고
    • Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb
    • Yagami K, Suh J Y, Enomoto-Iwamoto M, Koyama E, Abrams W R, Shapiro I M, Pacifici M, and Iwamoto M (1999) Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous ossification in the limb. J. Cell Biol. 147(5): 1097-1108.
    • (1999) J. Cell Biol , vol.147 , Issue.5 , pp. 1097-1108
    • Yagami, K.1    Suh, J.Y.2    Enomoto-Iwamoto, M.3    Koyama, E.4    Abrams, W.R.5    Shapiro, I.M.6    Pacifici, M.7    Iwamoto, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.