Dynamic duo takes down fungal villains

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 9, 2009, Pages 2971-2972

  Semighini, Camile P ^a   Heitman, Joseph ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 DEMETHOXY 17 (2 DIMETHYLAMINOETHYLAMINO)GELDANAMYCIN; AMPHOTERICIN B; ANTIFUNGAL AGENT; CALCINEURIN; CALCINEURIN INHIBITOR; CASPOFUNGIN; FLUCONAZOLE; FLUCYTOSINE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MYCOGRAB; PYRROLE DERIVATIVE; TANESPIMYCIN;

ANTIFUNGAL ACTIVITY; ANTIFUNGAL RESISTANCE; ASPERGILLUS; CANDIDA ALBICANS; CRYPTOCOCCAL MENINGITIS; DRUG EFFICACY; DRUG POTENTIATION; HUMAN; INVASIVE CANDIDIASIS; KERATITIS; MYCOSIS; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIFUNGAL AGENTS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MYCOSES;

EID: 62549140067     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0900801106     Document Type: Note

References (20)

1. Cowen LE, Steinbach WJ (2008) Stress, drugs, and evolution: The role of cellular signaling in fungal drug resistance. Eukaryot Cell 7:747-764.
2. Cowen LE, et al. (2009) Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci USA 106:2818-2823.
3. Rutherford SL, Lindquist S (1998) Hsp90 as a capacitor for morphological evolution. Nature 396:336-342.
4. Queitsch C, Sangster TA, Lindquist S (2002) Hsp90 as a capacitor of phenotypic variation. Nature 417:618-624.
5. Cowen LE, Lindquist S (2005) Hsp90 potentiates the rapid evolution of new traits: Drug resistance in diverse fungi. Science 309:2185-2189.
6. Cowen LE (2008) The evolution of fungal drug resistance: Modulating the trajectory from genotype to phenotype. Nat Rev Microbiol 6:187-198.
7. Mylonakis E (2008) Galleria mellonella and the study of fungal pathogenesis: Making the case for another genetically tractable model host. Mycopathologia 165:1-3.
8. Johnson MD, MacDougall C, Ostrosky-Zeichner L, Perfect JR, Rex JH (2004) Combination antifungal therapy. Antimicrob Agents Chemother 48:693-715.
9. Bae J, et al. (2007) Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell. J Immunol 178:7730-7737.
10. Matthews RC, et al. (2003) Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90. Antimicrob Agents Chemother 47:2208-2216.
11. Pachl J, et al. (2006) A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. Clin Infect Dis 42:1404-1413.
12. Cowen LE, Carpenter AE, Matangkasombut O, Fink GR, Lindquist S (2006) Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell 5:2184-2188.
13. Cruz MC, et al. (2002) Calcineurin is essential for survival during membrane stress in Candida albicans. EMBO J 21:546-559.
14. Sanglard D, Ischer F, Marchetti O, Entenza J, Bille J (2003) Calcineurin A of Candida albicans: Involvement in antifungal tolerance, cell morphogenesis, and virulence. Mol Microbiol 48:959-976.
15. Steinbach WJ, Reedy JL, Cramer RA, Jr, Perfect JR, Heitman J (2007) Harnessing calcineurin as a novel antiinfective agent against invasive fungal infections. Nat Rev Microbiol 5:418-430.
16. Onyewu C, Afshari NA, Heitman J (2006) Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrob Agents Chemother 50:3963-3965.
17. Onyewu C, et al. (2007) Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrob Agents Chemother 51:3743-3746.
18. Uppuluri P, Nett J, Heitman J, Andes D (2008) Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob Agents Chemother 52:1127-1132.
19. Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA (2001) Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Res 61:4003-4009.
20. Ramsdale M (2008) Programmed cell death in pathogenic fungi. Biochim Biophys Acta 1783:1369-1380.