4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) enhances invasiveness of lung cancer cells by up-regulating contactin-1 via the α7 nicotinic acetylcholine receptor/ERK signaling pathway

Chemico-Biological Interactions

Volumn 179, Issue 2-3, 2009, Pages 154-159

  Hung, Yu Hsuan ^a   Hung, Wen Chun ^b  

^a NATIONAL DONG HWA UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

4 (Methylnitrosamino) 1 (3 pyridyl) 1 butanone (NNK); AKT; Contactin 1; Extracellular signal regulated kinase (ERK); Nicotinic acetylcholine receptor (nAChR)

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; ALPHA BUNGAROTOXIN; BUNGAROTOXIN RECEPTOR; CELL ADHESION MOLECULE; CONTACTIN; CONTACTIN 1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUTRALIZING ANTIBODY; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG CARCINOGENICITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LUNG CANCER; LUNG CARCINOGENESIS; PROMOTER REGION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION;

BUNGAROTOXINS; CELL ADHESION MOLECULES, NEURONAL; CONTACTIN 1; CONTACTINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION PROFILING; HUMANS; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; NITROSAMINES; RECEPTORS, NICOTINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

NICOTIANA TABACUM;

EID: 62549124983     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.10.042     Document Type: Article

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