Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstructive sleep apnea syndrome

European Archives of Oto-Rhino-Laryngology

Volumn 266, Issue 3, 2009, Pages 449-454

  Bayazit, Yildirim A ^a   Yilmaz, Metin ^a   Erdal, Emin ^b   Ciftci, Tansu Ulukavak ^a   Ceylan, Alper ^a   Kokturk, Oguz ^a   Celenk, Fatih ^a   Kemaloglu, Yusuf K ^a  

^a GAZI UNIVERSITY   (Turkey)

^b MERSIN UNIVERSITY   (Turkey)

Author keywords

Nitric oxide; Nitric oxide synthase; Obstructive sleep apnea; Polymorphism

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ADULT; AGED; AMINO ACID SUBSTITUTION; APNEA; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DISEASE SEVERITY; EXON; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HEART ARRHYTHMIA; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INTRON; MALE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; SEX DIFFERENCE; SLEEP APNEA SYNDROME; SMOKING; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; AGED; EXONS; FEMALE; GENOTYPE; HUMANS; INTRONS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; NITRIC OXIDE SYNTHASE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYSOMNOGRAPHY; SEVERITY OF ILLNESS INDEX; SLEEP APNEA, OBSTRUCTIVE;

EID: 62549106557     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00405-008-0763-0     Document Type: Article

References (23)

1. S Lamas PA Marsden GK Li P Tempst T Michel 1992 Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform Proc Natl Acad Sci USA 89 6348 6352 10.1073/pnas.89.14.6348
2. K Miyahara T Kawamoto K Sase Y Yui K Toda LX Yang 1994 Cloning and structural characterization of human endothelial nitric oxidesynthase gene Eur J Biochem 223 719 726 10.1111/j.1432-1033.1994.tb19045.x
3. T Tsukada K Yokoyama T Arai F Takemoto S Hara A Yamada 1998 Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans Biochem Biophys Res Commun 245 190 193 10.1006/bbrc.1998.8267
4. Sydow K, Mondon CE, Cooke JP (2005) Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA. Vasc Med 10(Suppl):35-43. doi: 10.1191/1358863x05vm604oa
5. RC Hickner G Kemeny HW Stallings SM Manning KL McIver 2006 Relationship between body composition and skeletal muscle eNOS Int J Obes (Lond) 30 308 312 10.1038/sj.ijo.0803134
6. JL Gonzalez-Sanchez MT Martinez-Larrad ME Saez C Zabena MJ Martinez-Calatrava M Serrano-Rios 2007 Endothelial nitric oxide synthase haplotypes are associated with features of metabolic syndrome Clin Chem 53 91 97 10.1373/clinchem.2006.075176
7. R Alvarez V Alvarez CH Lahoz C Martinez J Pena JM Sanchez 1999 Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease J Neurol Neurosurg Psychiatry 67 733 736
8. M Yoshimura H Yasue M Nakayama Y Shimasaki H Sumida S Sugiyama 1998 A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese Hum Genet 103 65 69 10.1007/s004390050785
9. Y Shimasaki H Yasue M Yoshimura M Nakayama K Kugiyama H Ogawa 1998 Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction J Am Coll Cardiol 31 1506 1510 10.1016/S0735-1097(98)00167-3
10. Y Miyamoto Y Saito N Kajiyama M Yoshimura Y Shimasaki M Nakayama 1998 Endothelial nitric oxide synthase gene is positively associated with essential hypertension Hypertension 32 3 8
11. M Shigemitsu K Nishio T Kusuyama S Itoh N Konno T Katagiri 2007 Nocturnal oxygen therapy prevents progress of congestive heart failure with central sleep apnea Int J Cardiol 14 354 360 10.1016/j.ijcard.2006.03.018
12. HW Duchna M Orth G Schultze-Werninghaus C Guilleminault RA Stoohs 2006 Antihypertensive treatment and endothelium-dependent venodilation in sleep-disordered breathing Sleep Breath 10 115 122 10.1007/s11325-006-0057-y
13. S Teramoto H Kume T Matsuse T Ishii A Miyashita M Akishita 2003 Oxygen administration improves the serum level of nitric oxide metabolites in patients with obstructive sleep apnea syndrome Sleep Med 4 403 407 10.1016/S1389-9457(03) 00102-3
14. HW Duchna M Orth G Schultze-Werninghaus C Guilleminault RA Stoohs 2005 Long-term effects of nasal continuous positive airway pressure on vasodilatory endothelial function in obstructive sleep apnea syndrome Sleep Breath 9 97 103 10.1007/s11325-005-0024-z
15. C Zhang R Lopez-Ridaura DJ Hunter N Rifai FB Hu 2006 Common variants of the endothelial nitric oxide synthase gene and the risk of coronary heart disease among U.S. diabetic men Diabetes 55 2140 2147 10.2337/db05-1535
16. PW Franks J Luan I Barroso S Brage JL Gonzalez Sanchez U Ekelund 2005 Variation in the eNOS gene modifies the association between total energy expenditure and glucose intolerance Diabetes 54 2795 2801 10.2337/diabetes.54.9. 2795
17. K Berger F Stogbauer M Stoll J Wellmann A Huge S Cheng 2007 The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies Hum Genet 121 169 178 10.1007/s00439-006-0302-2
18. JL Lattimore I Wilcox M Skilton M Langenfeld DS Celermajer 2006 Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation Thorax 61 491 495 10.1136/thx.2004.039164
19. JW Weiss MD Liu J Huang 2007 Physiological basis for a causal relationship of obstructive sleep apnoea to hypertension Exp Physiol 92 21 26 10.1113/expphysiol.2006.035733
20. Z Tahawi N Orolinova IG Joshua M Bader EC Fletcher 2001 Altered vascular reactivity in arterioles of chronic intermittent hypoxic rats J Appl Physiol 90 2007 2013
21. YA Bayazit M Yilmaz O Kokturk ME Erdal T Ciftci T Gokdogan 2007 Association of GABA(B)R1 receptor gene polymorphism with obstructive sleep apnea syndrome ORL J Otorhinolaryngol Relat Spec 69 190 197 10.1159/000099230
22. YA Bayazit ME Erdal M Yilmaz TU Ciftci F Soylemez T Gokdogan 2006 Insulin receptor substrate gene polymorphism is associated with obstructive sleep apnea syndrome in men Laryngoscope 116 1962 1965 10.1097/01.mlg.0000235933.74319.80
23. YA Bayazit M Yilmaz T Ciftci E Erdal O Kokturk T Gokdogan 2006 Association of the -1438G/A polymorphism of the 5-HT2A receptor gene with obstructive sleep apnea syndrome ORL J Otorhinolaryngol Relat Spec 68 123 128 10.1159/000091216