Vasorelaxant effects of forsythide isolated from the leaves of Forsythia viridissima on NE-induced aortal contraction

Phytomedicine

Volumn 16, Issue 4, 2009, Pages 386-390

  Iizuka, T ^a,b   Sakai, H ^b   Moriyama, H ^c   Suto, N ^a   Nagai, M ^d   Bagchi, D ^e  

^a YOKOHAMA COLLEGE OF PHARMACY   (Japan)

^b HOSHI UNIVERSITY   (Japan)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^d OHU UNIVERSITY   (Japan)

^e UNIVERSITY OF HOUSTON   (United States)

Author keywords

Forsythia viridissima; Forsythide; Iridoid; ROC; Vasorelaxant activity

Indexed keywords

CALCIUM; FORSYTHIDE; NICARDIPINE; NORADRENALIN; PHORBOL DIACETATE; POTASSIUM; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CALCIUM TRANSPORT; ENZYME INHIBITION; ENZYME ISOLATION; FORSYTHIA VIRIDISSIMA; MALE; MEDICINAL PLANT; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; RAT; VASODILATATION;

ANIMALS; AORTA; CALCIUM; FORSYTHIA; HETEROCYCLIC COMPOUNDS, 2-RING; MALE; MONOSACCHARIDES; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NOREPINEPHRINE; PHORBOL ESTERS; PLANT EXTRACTS; PLANT LEAVES; POTASSIUM; RATS; RATS, WISTAR; VASODILATION; VASODILATOR AGENTS;

FORSYTHIA VIRIDISSIMA; OLEACEAE; RATTUS;

EID: 62549086973     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2008.09.011     Document Type: Article

References (19)

1. Breschi M.C., Martinotti E., Catalano S., Flamini G., Morelli I., and Pagni A.M. Vasoconstrictor activity of 8-O-acetylharpagide from Ajuga reptans. J. Nat. Prod. 55 (1992) 1145-1148
2. Chung B.S., Lee H.K., and Kim J.W. Studies on the iridoid glycoside of Ajuga spectabilis Nakai. Saengyak Hakhoechi 11 (1980) 15-23
3. Damtoft S., Franzyk H., and Jensen S.R. Biosynthesis of iridoids in Forsythia spp. Phytochemistry 37 (1994) 173-178
4. Ghisalberti E.L. Biological and pharmacological activity of naturally occurring iridoids and secoiridoids. Phytomedicine 5 (1998) 147-163
5. Iizuka T., and Nagai M. Vasorelaxant effects of forsythiaside from the fruits of Forsythia suspense. Yakugaku Zasshi 125 (2005) 219-224
6. Iizuka, T., Nagai, M., Morita, H., 2005. Vasorelaxant effects of phenylethanoids. 52nd Annual Meeting of the Japanese Society of Pharmacognosy, Kanazawa, Japan, p. 134.
7. Iizuka T., Moriyama H., and Nagai M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol. Pharm. Bull. 29 (2006) 177-179
8. 2+ pathways in smooth muscle plasmalemma. J. Membr. Biol. 59 (1981) 19-25
9. Nagai M., Noguchi M., Iizuka T., Otani K., and Kamata K. Vasodilator effects of des(alpha-carboxy-3,4-dihydroxyphenethyl)lithospermic acid (8-epiblechnic acid), a derivative of lithospermic acids in Salviae miltiorrhizae radix. Biol. Pharm. Bull. 19 (1996) 228-232
10. Nishibe S. The plant origins of herbal medicines and their quality evaluation. Yakugaku Zasshi 122 (2002) 363-379
11. Rasmussen H., Forder J., Kojima I., and Scriabine A. TPA-induced contraction of isolated rabbit vascular smooth muscle. Biochem. Biophys. Res. Commun. 122 (1984) 776-784
12. Rojas A., Bah M., Rojas J.I., and Gutierrez D.M. Smooth muscle relaxing activity of gentiopicroside isolated from Gentiana spathacea. Planta Med. 66 (2000) 765-767
13. Sarg M., El-Domiaty M., Salama O.M., Bishr M.M., and El-Gindy A.R. Pharmacognostical study of the rhizomes and roots of Gentiana kurroo Royle. Mansoura J. Pharm. Sci. 6 (1990) 49-72
14. Schapoval E.E., Vargas M.R., Chaves C.G., Bridi R., Zuanazzi J.A., and Henriques A.T. Antiinflammatory and antinociceptive activities of extracts and isolated compounds from Stachytarpheta cayennensis. J. Ethnopharmacol. 60 (1998) 53-59
15. Tokar M., and Klimek B. Isolation and identification of biologically active compounds from Forsythia viridissima flowers. Acta Pol. Pharm. 61 (2005) 191-197
16. Weber L.P., Chow W.L., Moshenko J., Belsher S., and MacLeod K.M. Pharmacological investigation of signaling mechanisms contributing to phasic and tonic components of the contractile response of rat arteries to noradrenaline. Can. J. Physiol. Pharmacol. 73 (1995) 594-601
17. Wong I.Y., Huang Y., He Z.D., Lau C.W., and Chen Z.Y. Relaxing effects of Ligustrum purpurascens extract and purified acteoside in rat aortic rings. Planta Med. 67 (2001) 317-321
18. 13C NMR data for 10 phenylethanoid glycosides. Magn. Reson. Chem. 42 (2004) 659-662
19. Yamahara J., Kobayashi M., Matsuda H., and Aoki S. Anticholinergic action of Swertia japonica and an active constituent. J. Ethnopharmacol. 33 (1991) 31-35