An assessment of dietary docosahexaenoic acid requirements for brain accretion and turnover during early childhood

World Review of Nutrition and Dietetics

Volumn 99, Issue , 2009, Pages 97-104

  Hadley, Kevin B ^a   Ryan, Alan S ^a   Nelson, Edward B ^a   Salem, Norman ^a  

^a Martek Biosciences Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID;

BRAIN; BRAIN LEVEL; DIET; FETUS DEVELOPMENT; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; HOMEOSTASIS; HUMAN; INFANT; METABOLISM; NEWBORN; NUTRITIONAL REQUIREMENT; PHYSIOLOGY; PRENATAL DEVELOPMENT; PRESCHOOL CHILD; REVIEW;

BRAIN; BRAIN CHEMISTRY; CHILD, PRESCHOOL; DIET; DOCOSAHEXAENOIC ACIDS; FETAL DEVELOPMENT; GESTATIONAL AGE; HOMEOSTASIS; HUMANS; INFANT; INFANT, NEWBORN; NUTRITIONAL REQUIREMENTS;

EID: 62449340265     PISSN: 00842230     EISSN: 16623975     Source Type: Book Series    
DOI: 10.1159/000193000     Document Type: Article

References (60)

1. Beard JL, Connor JR: Iron status and neural functioning. Annu Rev Nutr 2003;23:41-58.
2. Grantham-McGregor S, Ani C: A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr 2001;131:649S-68S.
3. Lozoff B: Perinatal iron deficiency and the developing brain. Pediatr Res 2000;48:137-139.
4. O'Brien JS, Sampson EL: Fatty acid and fatty acid aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin. J Lipid Res 1965;6:545-551.
5. Salem N Jr: Omega-3 fatty acids: molecular and biochemical aspects; in Spiller J, Scala GA (eds): Current Topics in Nutrition and Disease. New York, Liss, 1989, pp 109-228.
6. Svennerholm L: Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res 1968;9:570-579.
7. Breckenridge WC, Gombos G, Morgan IG: The lipid composition of adult rat brain synaptosomal plasma membranes. Biochim Biophys Acta 1972;266:695-707.
8. Stillwell W, Shaikh SR, Zerouga M, Siddiqui R, Wassall SR: Docosahexaenoic acid affects cell signaling by altering lipid rafts. Reprod Nutr Dev 2005;45:559-579.
9. Sang N, Chen C: Lipid signaling and synaptic plasticity. Neuroscientist 2006;12:425-434.
10. Darios F, Davletov B: Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin-3. Nature 2006;440:813-817.
11. Lesa GM, Palfreyman M, Hall DH, et al: Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans. J Cell Sci 2003;116: 4965-4975.
12. Coti Bertrand P, O'Kusky JR, Innis SM: Maternal dietary (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain. J Nutr 2006;136: 1570-1575.
13. Rao JS, Ertley RN, Lee HJ, et al: n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Mol Psychiatry 2007;12:36-46.
14. Ahmad A, Moriguchi T, Salem N: Decrease in neuron size in docosahexaenoic acid-deficient brain. Pediatr Neurol 2002;26:210-218.
15. Ahmad A, Murthy M, Greiner RS, Moriguchi T, Salem N Jr: A decrease in cell size accompanies a loss of docosahexaenoate in the rat hippocampus. Nutr Neurosci 2002;5:103-113.
16. Sakamoto T, Cansev M, Wurtman RJ: Oral supplementation with docosahexaenoic acid and uridine 5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res 2007; 1182:50-59.
17. Marszalek JR, Kitidis C, Dararutana A, Lodish HF: Acyl-CoA synthetase-2 overexpression enhances fatty acid internalization and neurite outgrowth. J Biol Chem 2004;279:23882-23891.
18. Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G: Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res 2006;1088:83-92.
19. Vancassel S, Leman S, Hanonick L, et al: n-3 polyunsaturated fatty acid supplementation reverses stress-induced modifications on brain monoamine levels in mice. J Lipid Res 2008;49:340-348.
20. Chalon S: Omega-3 fatty acids and monoamine neurotransmission. Prostaglandins Leukot Essent Fatty Acids 2006;75:259-269.
21. Bazan NG: Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci 2006;29:263-271.
22. Birch EE, Garfield S, Castaneda Y, Hughbanks-Wheaton D, Uauy R, Hoffman D: Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula. Early Hum Dev 2007;83:279-284.
23. Ng KF, Innis SM: Behavioral responses are altered in piglets with decreased frontal cortex docosa-hexaenoic acid. J Nutr 2003;133:3222-3227.
24. Vancassel S, Blondeau C, Lallemand S, et al: Hyper-activity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex. Behav Brain Res 2007;180:119-126.
25. Williams CM, Burdge G: Long-chain n-3 PUFA: plant vs. marine sources. Proc Nutr Soc 2006;65:42- 50.
26. Martinez M: Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. World Rev Nutr Diet. Basel, Karger, 1994, vol 75, pp 70-78.
27. Cunnane SC, Francescutti V, Brenna JT, Crawford MA: Breast-fed infants achieve a higher rate of brain and whole-body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids 2000;35:105-111.
28. Jackson KA, Gibson RA: Weaning foods cannot replace breast milk as sources of long-chain polyun-saturated fatty acids. Am J Clin Nutr 1989;50:980- 982.
29. Su HM, Bernardo L, Mirmiran M, et al: Bio-equivalence of dietary α-linolenic and docosa-hexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatr Res 1999;45:87-93.
30. Su HM, Bernardo L, Mirmiran M, Ma XH, Nathanielsz P W, Brenna JT: Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids 1999;34: S347-S350.
31. Rapoport SI, Chang MC, Spector AA: Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J Lipid Res 2001;42:678-685.
32. Cunnane SC: Application of new methods and analytical approaches to research on polyunsaturated fatty acid homeostasis. Lipids 2001;36:975-979.
33. Martinez M: Tissue levels of polyunsaturated fatty acids during early human development. J Pediatr 1992;120:S129-S138.
34. Rapoport SI: What are the normal rates of human brain metabolism of arachidonic and docosa-hexaenoic acids, and what may happen when their metabolic balance is altered by dietary n-3 PUFA deprivation? ISSFAL Australia, 2006, p 143.
35. Matsuzawa J, Matsui M, Konishi T, et al: Age-related volumetric changes of brain gray and white matter in healthy infants and children. Cereb Cortex 2001;11:335-342.
36. Rapoport SI, Rao JS, Igarashi M: Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot Essent Fatty Acids 2007;77:251-261.
37. Scott BL, Bazan NG: Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. Proc Natl Acad Sci USA 1989;86:2903-2907.
38. Lin YH, Salem N Jr: Whole-body distribution of deu-terated linoleic and α-linolenic acids and their metabolites in the rat. J Lipid Res 2007;48:2709-2724.
39. Su HM, Huang MC, Saad NM, Nathanielsz P W, Brenna JT: Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo: a stable isotope tracer study. J Lipid Res 2001;42:581-586.
40. Food and Nutrition Board, Institute of Medicine Panel on Macronutrients ScotSEoDRI: Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, National Academies Press, 2005.
41. Su HM, Bernardo L, Mirmiran M, Ma XH, Nathanielsz PW, Brenna JT: Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids 1999; 34(suppl):S347-S350.
42. Innis SM: Dietary (n-3) fatty acids and brain development. J Nutr 2007;137:855-859.
43. Dietary Reference Intakes for Energy - Summary 2005.
44. Su HM, Huang MC, Saad NM, Nathanielsz P W, Brenna JT: Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res 2001;42:581-586.
45. Simopoulos A, Leaf, A, Salem, N: Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids. International Society for the Study of Fatty Acids and Lipids, August 2007.
46. Report of a Joint Expert Consultation: Fats and Oils in Human Nutrition. Rome, WHO/FAO, 1994, pp 49-55.
47. Makrides M, Neumann MA, Gibson RA: Effect of maternal docosahexaenoic acid supplementation on breast milk composition. Eur J Clin Nutr 1996;50: 352-357.
48. Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arterburn LM: Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007;85: 1457-1464.
49. Demar JC Jr, Dimartino C, Baca AW, Lefkowitz W, Salem N Jr: Effect of dietary docosahexaenoic acid on biosynthesis of docosahexaenoic acid from α-linolenic acid in young rats. J Lipid Res 2008;49: 1963-1980.
50. Salem N Jr, Wegher B, Mena P, Uauy R: Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. Proc Natl Acad Sci USA 1996;93:49-54.
51. Carnielli V P, Simonato M, Verlato G, et al: Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsatu-rated fatty acids. Am J Clin Nutr 2007;86:1323- 1330.
52. Jamieson EC, Farquharson J, Logan RW, et al: Infant cerebellar gray and white matter fatty acids in relation to age and diet. Lipids 1999;34:1065-1071.
53. Farquharson J, Cockburn F, Patrick WA, Jamieson EC, Logan RW: Infant cerebral cortex phospholipid fatty-acid composition and diet. Lancet 1992;340: 810-813.
54. Diau GY, Hsieh AT, Nagy SA, Wijendran V, Nathanielsz P W, JTB: The influence of long chain polyunsaturate supplementation on docosa-hexaenoic acid and arachidonic acid in baboon neo-nate central nervous system. BMC Med 2005;3: 1-12.
55. Sarkadi-Nagy E, Wijendran V, Diau GY, et al: Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. J Lipid Res 2004;45:71-80.
56. Hoffman DR, Theuer RC, Castaneda YS, et al: Maturation of visual acuity is accelerated in breastfed term infants fed baby food containing DHA-enriched egg yolk. J Nutr 2004;134:2307-2313.
57. Institute of Medicine of the National Academies: Dietary Reference Intakes: Energy, Carbohydrate, Fiber, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, National Academies Press, 2002.
58. Makrides M, Gibson RA, Collins CT, McPhee AJ: The DINO trial outcomes: does high-dose dietary docosahexaenoic acid improve the neurodevelop-mental outcome of preterm infants? Kansas City, International Society for the Study of Fatty Acids and Lipids, 2008.
59. Martinez M: Severe deficiency of docosahexaenoic acid in peroxisomal disorders: a defect of ?4 desatu-ration? Neurology 1990;40:1292-1298.
60. DeMar JC Jr, Ma K, Bell JM, Rapoport SI: Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. J Neurochem 2004;91:1125-1137.