Challenges and pitfalls of morphologic identification of fungal infections in histologic and cytologic specimens : A Ten-Year retrospective review at a single institution

American Journal of Clinical Pathology

Volumn 131, Issue 3, 2009, Pages 364-375

  Sangoi, Ankur R ^a,b   Rogers, William M ^a   Longacre, Teri A ^a   Montoya, Jose G ^a   Baron, Ellen Jo ^a   Banaei, Niaz ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Culture; Cytology; Fungal; Fungi; Histology; Hyphae; Identification; Mold; Morphology; Yeast

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; ECHINOCANDIN; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; POSACONAZOLE; VORICONAZOLE;

ADULT; ARTICLE; ASPERGILLUS; CANDIDA; COCCIDIOIDES IMMITIS; CRYPTOCOCCUS NEOFORMANS; CYTOLOGY; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DRUG EFFICACY; FEMALE; FUNGUS CULTURE; FUNGUS GROWTH; FUNGUS IDENTIFICATION; FUSARIUM; GOLD STANDARD; GROWTH RATE; HISTOPATHOLOGY; HISTOPLASMA CAPSULATUM; HUMAN; MALE; MORPHOLOGY; MOULD; MYCOSIS; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCEDOSPORIUM APIOSPERMUM; STAINING; TISSUE SECTION; TRICHOPHYTON; YEAST; ZYGOMYCETES; AGED; CHILD; FUNGUS; INFANT; MICROBIOLOGY; MIDDLE AGED; PRESCHOOL CHILD; STATISTICS; ULTRASTRUCTURE;

ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; CYTOLOGICAL TECHNIQUES; DIAGNOSTIC ERRORS; FEMALE; FUNGI; HUMANS; INFANT; MALE; MIDDLE AGED; MYCOSES; RETROSPECTIVE STUDIES;

EID: 62449329439     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/AJCP99OOOZSNISCZ     Document Type: Article

References (39)

1. Hayden RT, Qian X, Roberts GD, et al. In situ hybridization for the identification of yeastlike organisms in tissue section. Diagn Mol Pathol. 2001;10:15-23.
2. Schwarz J. The diagnosis of deep mycoses by morphologic methods. Hum Pathol. 1982;13:519-533.
3. Watts JC. Surgical pathology and the diagnosis of infectious diseases [editorial). Am J Clin Pathol. 1994;102:711-712.
4. Cody DT Jr, Neel HB III, Ferreiro JA, et al. Allergic fungal sinusitis: the Mayo Clinic experience. Laryngoscope. 1994;104:1074-1079.
5. Granville L, Chirala M, Cernoch P, et al. Fungal sinusitis: histologic spectrum and correlation with culture. HUM Pathol. 2004;35:474-481.
6. Morpeth JF, Rupp NT, Dolen WK, et al. Fungal sinusitis: an update. Ann Allergy Asthma Immunol. 1996;76:128-140.
7. Renshaw AA. The relative sensitivity of special stains and culture in open lung biopsies. Am ] Clin Pathol. 1994;102:736-740.
8. Steer A Rothlauf MV, Morse WC, et al. Cryostat tissue section culture for Mycobacterium tuberculosis. Am Rev Respir Dis. 1967;96:758-765.
9. Tarrand JJ, Lichterfeid M, Warraich I, et al. Diagnosis of invasive septate mold infections: a correlation of microbiological culture and histologic or cytologic examination. Am ] Clin Pathol. 2003;119:854-858.
10. Ulbright TM, Katzenstein AL. Solitary necrotizing granulomas of the lung: differentiating features and etiology. Am ] Surg Pathol. 1980;4:13-28.
11. Weydert JA, Van Natta TL, DeYoung BR. Comparison of fungal culture versus surgical pathology examination in the detection of Histoplasma in surgically excised pulmonary granulomas. Arch Pathol Lab Med. 2007;131:780-783.
12. Kenney M. Misleading morphology of parasites and fungi in tissue sections. Pathol Annu. 1981;16(pt l):313-335.
13. Schofield CM, Murray CK, Horvath EE, et al Correlation of culture with histopathology in fungal burn wound colonization and infection. Burns. 2007;33:341-346.
14. Watts JC, Chandler FW. Morphologic identification of mycelial pathogens in tissue sections: a caveat [editorial). Am J ClmPathol. 1998;109:1-2.
15. Lopez FA, Crowley RS, Wastila L, et al. Scedosporium apiospermum (Pseudalkscheria boydii) infection in a heart transplant recipient: a case of mistaken identity. ] Heart Lung Transplant. 1998;17:321-324.
16. Larone DH. Medically Important Fungi: A Laboratory Guide to Identification. 3rd ed. Washington, DC: ASM Press; 1995.
17. Abbott JJ, Hamacher KL, Ahmed I. In situ hybridization in cutaneous deep fungal infections: a valuable diagnostic adjunct to fungal morphology and tissue cultures. J Cutan Pathol. 2006;33:426-432.
18. Eyzaguirre E, Haque AK. Application of immunohistochemistry to infections. Arch Pathol Lab Med. 2008;132:424-431.
19. Hayden RT, Isotalo PA, Parrett T, et al. In situ hybridization for the differentiation of Aspergillus, Fusarium, and Pseudalkscheria species in tissue section. Diagn Mol Pathol. 2003;12:21-26.
20. Hayden RT, Qian X, Procop GW, et al. In situ hybridization for the identification of filamentous fungi in tissue section. Diagn Mol Pathol. 2002;11:119-126.
21. Comely OA, Vehreschild JJ, Ullmann AJ. Is there a role for polyenes in treating invasive mycoses? Curr Opin Infect Dis. 2006;19:565-570.
22. Girois SB, Chapuis F, Decullier E, et al. Adverse effects of antifungal therapies in invasive fungal infections: review and meta-analysis. Eur ] Clin Microbiol Infect Dis. 2006;25:138-149.
23. Anthony PP. A guide to the histological identification of fungi in tissues. J Clin Pathol. 1973;26:828-831.
24. Kradin RL, Mark EJ. The pathology of pulmonary disorders due to Aspergillus spp. Arch Pathol Lab Med. 2008;132:606-614.
25. Mohindra S, Mohindra S, Gupta R, et al. Rhinocerebral mucormycosis: the disease spectrum in 27 patients. Mycoses. 2007;50:290-296.
26. Rajshekhar V. Surgical management of intracranial fungal masses. Neurol India. 2007;55:267-273.
27. Siddiqui AA, Shah AA, Bashir SH. Craniocerebral aspergillosis of sinonasal origin in immunocompetent patients: clinical spectrum and outcome in 25 cases. Neurosurgery. 2004;55:602-613.
28. Young RF, Gade G, Grinnell V. Surgical treatment for fungal infections in the central nervous system. J Neurosurg. 1985;63:371-381.
29. Ciesla MC, Kammeyer PL, Yeldandi V, et al. Identification of the asexual state of Rhizopus species on histologic tissue sections in a patient with rhinocerebral mucormycosis. Arch Pathol Lab Med. 2000;124:883-887.
30. Liu K, Howell DN, Perfect JR, et al. Morphologic criteria for the preliminary identification of Fusarium, Paecibmyces, and Acremonium species by histopathology. Am J Clin Pathol. 1998;109:45-54.
31. Fukuzawa M, Inaba H, Hayama M, et al. Improved detection of medically important fungi by immunoperoxidase staining with polyclonal antibodies. Virchows Arch. 1995;427:407-414.
32. Jensen HE, Schonheyder HC, Hotchi M, et al. Diagnosis of systemic mycoses by specific immunohistochemical tests. APMIS. 1996;104:241-258.
33. Kaufman L. Immunohistologic diagnosis of systemic mycoses; an update. Eur j Epidemiol. 1992;8:377-382.
34. Kimura M, McGinnis MR. Fontana-Masson-stained tissue from culture-proven mycoses. Arch Pathol Lab Med. 1998;122:1107-1111.
35. Powers CN. Diagnosis of infectious diseases: a cytopathologist's perspective. Clin Microbiol Rev. 1998;11:341-365.
36. Reed JA, Hemann BA, Alexander JL, et al. Immunomycology: rapid and specific immunocytochemical identification of fungi in formalin-fixed, paraffin-embedded material. J Histochem Cytochem. 1993;41:1217-1221.
37. Elias Costa MR, Da Silva Lacaz C, Kawasaki M, et al. Conventional versus molecular diagnostic tests. Med Mycol. 2000;38(suppl 1): 139-145.
38. Ghadiali MT, Deckard NA, Farooq U, et al. Frozen-section biopsy analysis for acute invasive fungal rhinosinusitis. Otolaryngol Head Neck Surg. 2007;136:714-719.
39. Hofman V, Castillo L, Beds F, et al. Usefulness of frozen section in rhinocerebralmucormycosis diagnosis and management. Pathology. 2003;35:212-216.