The spatio-temporal dynamics of ligament healing

Wound Repair and Regeneration

Volumn 17, Issue 2, 2009, Pages 206-215

  Chamberlain, Connie S ^a   Crowley, Erin ^a   Vanderby, Ray ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; DISEASE COURSE; GRANULATION TISSUE; HEMATOPOIETIC CELL; IMMUNOHISTOCHEMISTRY; KNEE LIGAMENT; LIGAMENT INJURY; MACROPHAGE; MICROANGIOGRAPHY; MITOSIS; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; WOUND HEALING;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD43; APOPTOSIS; BIOMECHANICS; DISEASE MODELS, ANIMAL; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MACROPHAGES; MEDIAL COLLATERAL LIGAMENT, KNEE; NEUTROPHILS; RATS; RATS, WISTAR; T-LYMPHOCYTES; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING; WOUNDS, PENETRATING;

EID: 62449274851     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2009.00465.x     Document Type: Article

References (32)

1. Levenson SM, Geever EF, Crowley LV, Oates JF, Berard CW, Rosen H. The healing of rat skin wounds. Ann Surg 1965 161 : 293 309.
2. Lin TW, Cardenas L, Soslowsky LJ. Biomechanics of tendon injury and repair. J Biomech 2004 37 : 865 77.
3. Marsolais D, Cote CH, Frenette J. Neutrophils and macrophages accumulate sequentially following Achilles tendon injury. J Orthop Res 2001 19 : 1203 9.
4. Frank C, Schachar N, Dittrich D. Natural history of healing in the repaired medial collateral ligament. 1983 1 : 179 88.
5. Clark RAF. Wound repair: overview and general considerations. In : Clark RAF, editor. The molecular and cellular biology of wound repair. New York : Plenum, 1995 : 3 50.
6. Frank C, Amiel D, Akeson WH. Healing of the medial collateral ligament of the knee. A morphological and biochemical assessment in rabbits. Acta Orthop Scand 1983 54 : 917 23.
7. Clark RAF. Cutaneous tissue repair: basic biologic considerations. J Am Acad Dermatol 1985 13 : 701 25.
8. R Development Core Team. A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-00-3. Available at : 2006. Accessed January 2008.
9. Nakamura N, Horibe S, Matsumoto N, Tomita T, Natsuume T, Kaneda Y, Shino K, Ochi T. Transient introduction of a foreign gene into healing rat patellar ligament. J Clin Invest 1996 97 : 226 31.
10. Chbinou N, Frenette J. Am J Physiol Regul Integr Comp Physiol 2004 286 : R952 7.
11. Paterson CA, Williams RN, Parker AV. Characteristics of polymorphonuclear leukocytes infiltration into the alkali burned eye and the influence of sodium citrate. Exp Eye Res 1984 39 : 701 8.
12. Iwuagwu FC, McGrouther DA. Early cellular response in tendon injury: the effect of loading. Plas Reconstr Surg 1998 102 : 2064 71.
13. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res 2002 53 : 31 47.
14. Kawamura S, Ying L, Kim HJ, Dynybil C, Rodeo S. Macrophages accumulate in the early phase of tendon-bone healing. J Orthoped Res 2005 23 : 1425 32.
15. Baum CL, Arpey CJ. Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg 2005 31 : 674 86.
16. Peterson JM, Barbul A, Breslin RJ, Wasserkrug HL, Efron G. Significance of T-lymphocytes in wound healing. Surgery 1987 102 : 300 5.
17. Efron JE, Frankel HL, Lazarou SA, Wasserkrug HL, Barbul A. Wound healing and T-lymphocytes. J Surg Res 1990 48 : 460 3.
18. Davis PA, Corless DJ, Aspinall R, Wastell C. Effect of CD4+ and CD8+ cell depletion on wound healing. Br J Surg 2001 88 : 298 304.
19. McLennan IS. Degenerating and regenerating skeletal muscles contain several subpopulations of macrophages with distinct spatial and temporal distributions. J Anat 1996 188 : 17 28.
20. McLennan IS. Resident macrophages (ED2 and ED3-positive) do not phagocytose degeneration rat skeletal muscle fibres. Cell Tissue Res 1993 272 : 193 6.
21. Massimino ML, Rapizzi E, Cantini M, Libera LD, Mazzoleni F, Arslan P, Carraro U. ED2+ macrophages increase selectively myofibroblast proliferation in muscle cultures. Biochem Biophys Res Commun 1997 235 : 754 9.
22. Moestrup SK, Moler HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 2004 36 : 347 54.
23. Alon T, Hemo I, Tiin A, Pe'er J, Stone J, Keshet E. Vascular endothelial growth factor acts as a survival factor for the newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1995 1 : 1024 8.
24. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995 146 : 1029 39.
25. Amemiya T, Sasamura H, Mifune M, Kitamura Y, Hirahashi J, Hayashi M, Saruta T. Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells. Kidney Int 1999 56 : 2055 63.
26. Provenzano PP, Hayashi K, Kunz DN, Markel MD, Vanderby Jr. R Healing of subfailure ligament: comparison between immature and mature ligaments in a rat model. J Orthop Res 2002a 20 : 975 83.
27. Brown DL, Kao WWY, Greenhalgh DG. Apoptosis down-regulates inflammation under the advancing epithelial wound edge: delayed patterns in diabetes and improvement with topical growth factors. Surgery 1997 121 : 372 80.
28. Desmouliere A, Redard M, Darby I, Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. AJP 1995 146 : 56 66.
29. Lokmic Z, Darby IA, Thompson EW, Mitchell GM. Time course analysis of hypoxia, granulation tissue and blood vessel growth, and remodeling in healing rat cutaneous incisional primary intention wounds. Wound Rep Reg 2006 14 : 277 88.
30. Liu PPY, Cheuk YC, Hung LK, Ru SC, Chan KM. Increased apoptosis at the late stage of tendon healing. Wound Rep Reg 2007 15 : 702 7.
31. Frank CB, Loitz BJ, Shrive NG. Injury location affects ligament healing. A morphological and mechanical study of the healing rabbit medial collateral ligament. Acta Orthop Scand 1995 66 : 455 62.
32. Provenzano PP, Heisey D, Hayashi K, Lakes R, Vanderby R Jr. Subfailure damage in ligament: a structural and cellular evaluation. J Appl Physiol 2002 92 : 362 71.