Calcium and phosphorus homeostasis

Blood Purification

Volumn 27, Issue 4, 2009, Pages 387-394

  Taylor, Jeremy G ^a   Bushinsky, David A ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

1,25 dihydroxyvitamin D; Calcium; Klotho; Phosphorus; TRPV channels

Indexed keywords

CALCIUM; COTRANSPORTER; FIBROBLAST GROWTH FACTOR; HORMONE; ION; KLOTHO PROTEIN; PARATHYROID HORMONE; PHOSPHORUS; VANILLOID RECEPTOR; VITAMIN D;

BONE; BONE DISEASE; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; CALCIUM METABOLISM; HUMAN; HYPERCALCEMIA; HYPOCALCEMIA; NEGATIVE FEEDBACK; NEPHROLITHIASIS; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; REGULATORY MECHANISM; REVIEW; VITAMIN D METABOLISM;

BONE AND BONES; CALCIUM; HOMEOSTASIS; HUMANS; INTESTINES; KIDNEY; PHOSPHORUS;

EID: 62449265146     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000209740     Document Type: Review

References (83)

1. Takeda E, Yamamoto H, Nashiki K, Sato T, Arai H, Taketani Y: Inorganic phosphate homeostasis and the role of dietary phosphorus. J Cell Mol Med 2004; 8: 191-200.
2. 2+ handling. Kidney Int 2006; 69: 650-654.
3. Renkema KY, Alexander RT, Bindels RJ, Hoenderop JG: Calcium and phosphate homeostasis: concerted interplay of new regulators. Ann Med 2008; 40: 82-91.
4. Hurwitz S: Homeostatic control of plasma calcium concentration. Crit Rev Biochem Mol Biol 1996; 31: 41-100.
5. Torres PU, Prie D, Molina-Bletry V, Beck L, Silve C, Friedlander G: Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int 2007; 71: 730-737.
6. Rajiv Kumar: Vitamin D and calcium transport. Kidney Int 1991; 40: 1177-1189.
7. Bushinsky DA, Monk RD: Calcium. Lancet 1998; 352: 306-311.
8. Bushinsky DA: Calcium and phosphorus homeostasis; in Greenberg AN (ed): Primer on Kidney Diseases, ed 4. Philadelphia, Elsevier, 2005, pp 120-130.
9. Calvi LM, Bushinsky DA: When is it appropriate to order an ionized calcium? J Am Soc Nephrol 2008; 19: 1257-1260.
10. Perez AV, Picotto G, Carpentieri AR, Rivoira MA, Peralta Lopez ME, Tolosa de Talamoni NG: Minireview on regulation of intestinal calcium absoprtion. Emphasis on molecular mechanisms of transcellular pathway. Digestion 2008; 77: 22-34.
11. Wasserman RH: Vitamin D and the dual processes of intestinal calcium absorption. J Nutr 2004; 134: 3137-3139.
12. Bronner F: Mechanisms of intestinal calcium absorption. J Cell Biochem 2003; 88: 387-393.
13. 2+ transport proteins by parathyroid hormone. Kidney Int 2005; 68: 1708-1721.
14. Christakos S, Dhawan P, Peng X, et al: New insights into the function and regulation of vitamin D target proteins. J Steroid Biochem Mol Biol 2007; 103: 405-410.
15. Malloy PJ, Pike JW, Feldman D: The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets. Endocr Rev 1999; 20: 156-188.
16. Fleet JC, Eksir F, Hance KW, Wood RJ: Vitamin D-inducible calcium transport and gene expression in three Caco-2 cell lines. Am JPhysiol Gastrointest Liver Physiol 2002; 283: G618-G625.
17. 3 in the intestine and kidney of mice. Endocrinology 2003; 144: 3885-3894.
18. 2+ transport in Caco-2 cell cultures. Am J Physiol 1998; 274:G389-G396.
19. Gentili C, Morelli S, de Boland AR: Characterization of PTH/PTHrP receptor in rat duodenum: effects of aging. J Cell Biochem 2003; 88: 1157-1167.
20. Nemere I, Larsson D: Does PTH have a direct effect on intestine? J Cell Biochem 2002; 86: 29-34.
21. Cotter AA, Cashman KD: Effect of 17 β-estradiol on transepithelial calcium transport in human intestinal-like Caco-2 cells and its interactions with 1,25-dihydroxy-cholecalciferol and 9-cis retinoic acid. Eur J Nutr 2006; 45: 234-241.
22. 3 level in the rat. J Bone Miner Res 1999; 14: 57-64.
23. Berndt T, Kumar R: Phosphatonins and the regulation of phosphate homeostasis. Annu Rev Physiol 2007; 69: 341-359.
24. Virkki LV, Biber J, Murer H, Forster IC: Phosphate transporters: a tale of two solute carrier families. Am J Physiol Renal Physiol 2007; 293:F643-F654.
25. 3 . Biochem J 1999; 343: 705-712.
26. Xu H, Bai L, Collins JF, Ghishan FK: Agedependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH) 2 vitamin D 3 . Am J Physiol Cell Physiol 2002; 282:C487-C493.
27. Hoenderop JG, Nilius B, Bindels RJ: Calcium absorption across epithelia. Physiol Rev 2005; 85: 373-422.
28. de Groot T, Bindels RJ, Hoenderop JG: TRPV5: an ingeniously controlled calcium channel. Kidney Int 2008; 74: 1241-1246.
29. 2+ and Mg + transport. Rev Physiol Biochem Pharmacol 2007; 158: 77-160.
30. Bushinsky DA, Coe FL, Moe OW: Nephrolithiasis; in Brenner BM (ed): The Kidney, ed 8. Philadelphia, Saunders, 2008, pp 1299-1349.
31. 2+ transport proteins by parathyroid hormone. Kidney Int 2005; 68: 1708-1721.
32. Kuro-o M: Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr Opin Nephrol Hypertens 2006; 15: 437-441.
33. Yoshida T, Fujimori T, Nabeshima YI: Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1 α-hydroxylase gene. Endocrinology 2002; 143: 683-689.
34. Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG: The β- glucuronidase Klotho hydrolyzes and activates the TRPV5 channel. Science 2005; 310: 490-493.
35. 2+ reabsorption via PKC-dependent plasma membrane accumulation of TRPV5. EMBO J 2006; 25: 4707-4716.
36. Sutton RA, Wong NL, Dirks JH: Effects of metabolic acidosis and alkalosis on sodium and calcium transport in the dog kidney. Kid Int 1979; 15: 520-533.
37. 2+ transport proteins. J Am Soc Nephrol 2006; 17: 617-626.
38. Lambers TT, Oancea E, de Groot T, Topala CN, Hoenderop JG, Bindels RJ: Extracellular pH dynamically controls cell surface delivery of functional TRPV5 channels. Mol Cell Biol 2007; 27: 1486-1494.
39. 3-independent stimulatory effect of estrogen on the expression of ECaC1 in kidney. J Am Soc Nephrol 2002; 13: 2102-2109.
40. 2+ . Cell Calcium 2001; 29: 417- 428.
41. Razzaque MS, Lanske B: The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis. J Endocrinol 2007; 194: 1-10.
42. Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS: Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci USA 1998; 95: 5372-5377.
43. i-IIc in maintaining phosphate homeostasis. Am J Hum Genet 2006; 78: 179-192.
44. Lorenz-Depiereux B, Benet-Pages A, Eckstein G, et al: Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. Am J Hum Genet 2006; 78: 193-201.
45. Levi M, Bruesegem S: Renal phosphatetransporter regulatory proteins and nephrolithiasis. N Engl J Med 2008; 359: 1171-1173.
46. icotransporter. Am J Renal Physiol 2000; 278:F792-F798.
47. Traebert M, Roth J, Biber J, Murer H, Kaissling B: Internalization of proximal tubular type II Na-P i cotransporter by PTH: immunogold electron microscopy. Am J Renal Physiol 2000; 278:F148-F154.
48. i 2 to endosomes. Am J Renal Physiol 2004; 287:F896-F906.
49. Levi M, Lotscher M, Sorribas V, et al: Cellular mechanisms of acute and chronic adaptation of rat renal P i transporter to alterations in dietary P i . Am J Renal Physiol 1994; 267: F900-F908.
50. i-cotransporter type II. Kidney Int 1998; 54: 1224-1232.
51. i cotransporter in response to a high-phosphate diet. Am J Renal Physiol 2005; 288:F587-F596.
52. Forster IC, Hernando N, Biber J, Murer H: Proximal tubular handling of phosphate: a molecular perspective. Kidney Int 2006; 70: 1548-1559.
53. Cai Q, Hodgson SF, Kao PC, et al: Inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. N Engl J Med 1994; 330: 1645-1649.
54. Econs MJ, Drezner MK: Tumor-induced osteomalacia - unveiling a new hormone. N Engl J Med 1994; 330: 1679-1681.
55. Shimada T, Hasegawa H, Yamazaki Y, et al: FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 2004; 19: 429-435.
56. White KE, Evans WE, O'Riordan JL, et al: Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 2000; 26: 345-348.
57. Berndt T, Craig TA, Bowe AE, Vassiliadis J, Reczek D: Secreted frizzled related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 2003; 785-794.
58. Karim Z, Gerard B, Bakouh N, et al: NHERF1 mutations and responsiveness of renal parathyroid hormone. N Engl J Med 2008; 359: 1128-1135.
59. Boyce B, Xing L: Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther 2007; 9(suppl 1):S1.
60. Martin TJ, Sims NA: Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med 2005; 11: 76-81.
61. Hamann KL, Lane NE: Parathyroid hormone update. Rheum Dis Clin North Am 2006; 32: 703-719.
62. Bilezikian JP: Combination anabolic and antiresorptive therapy for osteoporosis: opening the anabolic window. Curr Osteoporos Rep 2008; 6: 24-30.
63. Jilka RL: Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 2007; 40: 1434-1446.
64. Khosla S: Minireview: the OPG/RANKL/ RANK system. Endocrinology 2001; 142: 5050-5055.
65. 2+ as an extracellular signal in bone. Cell Calcium 2004; 35: 249-255.
66. Riccardi D, Park J, Lee WS, Gamba G, Brown EM, Hebert SC: Cloning and functional expression of a rat kidney extracellular calcium/ polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 1995; 92: 131-135.
67. 2+- sensing receptor from bovine parathyroid. Nature 1993; 366: 575-580.
68. Fudge N, Kovacs C: Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo. BMC Physiol 2004; 4: 5.
69. Miller S: Calcitonin - guardian of the mammalian skeleton or is it just a fish story? Endocrinology 2006; 147: 4007-4009.
70. Woodrow JP, Sharpe CJ, Fudge NJ, Hoff AO, Gagel RF, Kovacs CS: Calcitonin plays a critical role in regulating skeletal mineral metabolism during lactation. Endocrinology 2006; 147: 4010-4021.
71. Hendy GN, D'Souza-Li L, Yang B, Canaff L, Cole DE: Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. Hum Mutat 2000; 4: 281-296.
72. 2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest 2005; 115: 1651-1658.
73. 2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 2003; 112: 1906-1914.
74. Bianco SD, Peng JB, Takanaga H, et al: Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 2007; 22: 274-285.
75. Uy HL, Mundy GR, Boyce BF, et al: Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo. Cancer Res 1997; 57: 3194-3199.
76. Ramasamy I: Inherited disorders of calcium homeostasis. Clin Chim Acta 2008; 394:22-41.
77. Masuyama N, Stockmans I, Torrekens S, et al: Vitamin D receptor in chrondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts. J Clin Invest 2006; 116: 3150-3159.
78. Yu X, Ibrahimi OA, Goetz R, et al: Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology 2005; 146: 4647-4656.
79. 3 and phosphorus in vivo. J Biol Chem 2005; 280: 2543-2549.
80. 3 /VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol 2007; 103: 381-388.
81. Kurosu H, Ogawa Y, Miyoshi M, et al: Regulation of fibroblast growth factor-23 signaling by Klotho. J Biol Chem 2006; 281: 6120-6123.
82. Benet-Pages A, Orlik P, Strom TM, Lorenz-Depiereux B: An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet 2005; 14: 385-390.
83. Portable AA, Miller WL: Hereditary rickets revealed. Kidney Int 1998; 54: 1762-1764.