Covalent JNK inhibitors?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages

  Borhani, David W ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 (2,3 DIHYDROBENZ[B][1,4]DIOXIN 6 YL) 4H 1,2,4 TRIAZOLINE 3,5 DIONE; ALANINE; ARGININE; BI 78D3; BI 83C11; BI 83C9; CYSTEINE; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; THIOPHENE; TRIAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING SITE; COVALENT BOND; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; GENE MUTATION; HYDROGEN BOND; LETTER; OXIDATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MODIFICATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

HYDROGEN BONDING; MAP KINASE KINASE 4; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 62449177202     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812246106     Document Type: Letter

References (2)

1. Stebbins JL, et al. (2008) Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci USA 105:16809-16813.
2. Radl S (1997) 1,2,4-Triazoline-3,5-diones. Adv Heterocyclic Chem 67:119-205.