CD98hc (SLC3A2), a novel marker in renal cell cancer

European Journal of Clinical Investigation

Volumn 39, Issue 4, 2009, Pages 304-310

  Prager, G W ^a,b   Poettler, M ^a   Schmidinger, M ^a   Mazal, P R ^a   Susani, M ^a   Zielinski, C C ^a   Haitel, A ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Waehringer Guertel 18 20   (Austria)

Author keywords

CD98hc; Molecular targeting; Renal cell cancer

Indexed keywords

CD98HC ANTIGEN; CYTOKERATIN 7; MEMBRANE ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER TISSUE; CLEAR CELL CARCINOMA; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY CARCINOMA; MALE; ONCOCYTOMA; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; TUMOR DIFFERENTIATION;

ANTIGENS, CD98 HEAVY CHAIN; BLOTTING, WESTERN; CARCINOMA, RENAL CELL; FLOW CYTOMETRY; HUMANS; KIDNEY NEOPLASMS; STATISTICS AS TOPIC; TUMOR MARKERS, BIOLOGICAL;

EID: 62349139720     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2009.02096.x     Document Type: Article

References (19)

1. Dixon WT, Sikora LK, Demetrick DJ, Jerry LM. Isolation and characterization of a heterodimeric surface antigen on human melanoma cells and evidence that it is the 4F2 cell activation/proliferation molecule. Int J Cancer 1990 45 : 59 68.
2. Esteban F, Ruiz-Cabello F, Concha A, Perez AM, Delgado M, Garrido F. Relationship of 4F2 antigen with local growth and metastatic potential of squamous cell carcinoma of the larynx. Cancer 1990 66 : 1493 8.
3. Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A 2001 98 : 13784 9.
4. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch 2004 447 : 532 42.
5. Prager GW, Feral CC, Kim C, Han J, Ginsberg MH. CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J Biol Chem 2007 282 : 24477 84.
6. Feral CC, Nishiya N, Fenczik CA, Stuhlmann H, Slepak M, Ginsberg MH. CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A 2005 102 : 355 60.
7. Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C et al. Distinct domains of CD98hc regulate integrins and amino acid transport. J Biol Chem 2001 276 : 8746 52.
8. Tsumura H, Suzuki N, Saito H, Kawano M, Otake S, Kozuka Y et al. The targeted disruption of the CD98 gene results in embryonic lethality. Biochem Biophys Res Commun 2003 308 : 847 51.
9. Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R et al. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J Biol Chem 2004 279 : 54731 41.
10. Waldert M, Haitel A, Marberger M, Katzenbeisser D, Ozsoy M, Stadler E et al. Comparison of type I and II papillary renal cell carcinoma (RCC) and clear cell RCC. BJU Int 2008 102 (10 1381 4.
11. Mazal PR, Stichenwirth M, Koller A, Blach S, Haitel A, Susani M. Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study. Mod Pathol 2005 18 : 535 40.
12. Eble JN, Sauter G, Epstein JI. World Health Organization Classification of Tumours. Tumours of the Urinary System and Male Genital Organs. 9-87. 2007. Lyon, France : IARC. 1-1-2004.
13. Sobin LH. International Union Against Cancer: TNM Classification of Malignant Tumors, 6th ed. New York : Wiley 2002. pp. 180 3.
14. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982 6 : 655 63.
15. Jenq W, Cooper DR, Ramirez G. Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells. Connect Tissue Res 1996 34 : 161 74.
16. Gottesdiener KM, Karpinski BA, Lindsten T, Strominger JL, Jones NH, Thompson CB et al. Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. Mol Cell Biol 1988 8 : 3809 19.
17. Delahunt B, Eble JN. Papillary renal cell carcinoma: a clinicopathologic and immunohistochemical study of 105 tumors. Mod Pathol 1997 10 : 537 44.
18. Fuchs BC, Bode BP. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin Cancer Biol 2005 15 : 254 66.
19. Kanai Y, Endou H. Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr Drug Metab 2001 2 : 339 54.