Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia

Cardiovascular Research

Volumn 82, Issue 1, 2009, Pages 67-76

  Marshall, Melanie ^a   Anilkumar, Narayana ^a   Layland, Joanne ^a   Walker, Simon J ^a   Kentish, Jonathan C ^a   Shah, Ajay M ^a   Cave, Alison C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cardiomyocytes; Myofilaments; Phosphorylation; Protein phosphatase 2A; Troponin I

Indexed keywords

ADENOSINE A1 RECEPTOR AGONIST; CALPAIN; CYCLOPENTYLADENOSINE; LIPOPOLYSACCHARIDE; METHYLTRANSFERASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHOPROTEIN PHOSPHATASE 2A; TROPONIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBER MEMBRANE POTENTIAL; MOUSE; MYOCARDIAL DISEASE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOSINE; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ISOQUINOLINES; LIPOPOLYSACCHARIDES; METHYLATION; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN METHYLTRANSFERASES; PROTEIN PHOSPHATASE 2; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, ADENOSINE A1; SULFONAMIDES; TIME FACTORS; TROPONIN I;

EID: 62349124667     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp037     Document Type: Article

References (40)

1. Maeder M, Fehr T, Rickli H, Ammann P. Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 2006;129:1349-1366.
2. Parrillo JE. Pathogenic mechanisms of septic shock. N Engl J Med 1993;328:1471-1477.
3. Grocott-Mason RM, Shah AM. Cardiac dysfunction in sepsis: new theories and clinical implications. Intensive Care Med 1998;24:286-295.
4. Tavernier B, Li J-M, El-Omar MM, Lanone L, Yang Z-K, Trayer IP et al. Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats. FASEB J 2001;15:294-296.
5. Layland J, Cave AC, Warren C, Grieve DJ, Sparks E, Kentish JC et al. Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J 2005;19:1137-1139.
6. Layland J, Solaro RJ, Shah AM. Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res 2005;66:12-21.
7. Liu Q, Hofmann PA. Antiadrenergic effects of adenosine A1 receptor-mediated protein phosphatase 2a activation in the heart. Am J Physiol 2002;283:H1314-H1321.
8. Turowski P, Myles T, Hemmings BA, Fernandez A, Lamb NJ. Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55. Mol Biol Cell 1999;10:1997-2015.
9. Silverstein AM, Barrow CA, Davis AJ, Mumby MC. Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Proc Natl Acad Sci USA 2002;99:4221-4226.
10. + exchanger NHE1. J Biol Chem 2006;29:20252-20262.
11. Liu Q, Hofmann PA. Modulation of protein phosphatase 2A by adenosine A1 receptors in cardiomyocytes: role for p38 MAPK. Am J Physiol 2003;285:H97-H103.
12. 2- adrenergic receptor agonists: novel regulatory mechanism of keratinocyte migration. J Biol Chem 2003;278:22555-22562.
13. Feschenko MS, Stevenson E, Nairn AC, Sweadner KJ. A novel cAMP-stimulated pathway in protein phosphatase 2A activation. J Pharmacol Exp Ther 2002;302:111-118.
14. Ke Y, Wang L, Pyle WG, de Tombe PP, Solaro RJ. Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circ Res 2004;94:194-200.
15. Yasuoka C, Ihara Y, Ikeda S, Miyahara Y, Kondo T, Kohno S. Antapoptotic activity of AKT is down-regulated by Ca2+ in myocardial H9c2 cells. J Biol Chem 2004;279:51182-51192.
16. Layland J, Li J-M, Shah AM. Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes. J Physiol 2002;540:457-467.
17. Layland J, Grieve DJ, Cave AC, Sparks E, Solaro RJ, Shah AM. Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically. J Physiol 2004;556:835-847.
18. Sontag E, Hladik C, Montgomery L, Luangpiprom A, Mudrak I, Ogris E et al. Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J Neuropathol Exp Neurol 2004;63:1080-1091.
19. Douglas P, Moorhead GBG, Ye R, Lees-Miller SP. Protein phosphatases regulate DNA-dependent protein kinase activity. J Biol Chem 2001;276:18992-18998.
20. Yan Y, Mumby MC. Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2A. J Biol Chem 1999;274:31917- 31924.
21. Mumby MC, Russell KL, Garrard LJ, Green DD. Cardiac contractile protein phosphatases. J Biol Chem 1987;262:6257-6265.
22. Neumann J, Botnik P, Bodor GS, Jones LR, Schmitz W. Effects of adenosine receptor and muscarinic cholinergic receptor agonists on cardiac protein phosphorylation. Influence of pertussis toxin. J Pharmacol Exp Ther 1994;269:1310-1318.
23. Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y et al. P38-MAPK induced dephosphorylation of a-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Circ Res 2007;100:408-415.
24. Gergs U, Botnik P, Buchwalow I, Fabritz L, Matus M, Justus I et al. Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function. J Biol Chem 2004;279:40827-40834.
25. Ikehara T, Ikehara S, Imamura S, Shinjo F, Yasumoto T. Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B). Biochem Biophys Res Commun 2007;354:1052-1057.
26. Kremmer E, Ohst K, Kiefer J, Brewis N, Walter G. Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: Abundant expression of both forms in cells. Mol Cell Biol 1997;17:1692-1701.
27. Murata K, Wu J, Brautigan DL. B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A. Proc Natl Acad Sci 1997;94:10624-10629.
28. Chung H, Nairn AC, Murata K, Brautigan DL. Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favours association with the α4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry 1999;38:10371-10376.
29. Tolstykh T, Lee J, Vafai S, Stock JB. Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits. EMBO J 2000;19:5682-5691.
30. Glaser ND, Lukyanenko YO, Wang Y, Wilson GM, Rodgers TB. JNK activation decreases PP2A regulatory subunit B56a expression and mRNA stability and increases AUF1 expression in cardiomyocytes. Am J Physiol Heart Circ Physiol 2006;291:H1183-H1192.
31. Chen J, Parsons S, Brautigan DL. Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. J Biol Chem 1994;269:7957-7962.
32. Li M, Guo H, Damuni Z. Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney. Biochemistry 1995;34:1988-1996.
33. Fornerod M, Boer J, van Baal S, Jaegle M, von Lindern M, Murti KG et al. Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements. Oncogene 1995;10:1739-1748.
34. Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B et al. Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII. Biol Chem Hoppe Seyler 1994;375:113-126.
35. Li M, Makkinje A, Damuni Z. Molecular identification of I, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. Biochemistry 1996;35:6998-7002.
36. Sontag E, Luangpirom A, Hladik C, Mudrak I, Ogris E, Speciale S et al. Altered expression levels of the protein phosphatase 2A ABaC enzyme are associated with Alzheimer disease pathology. J Neuropathol Exp Neurol 2004;63:287-301.
37. Brust TB, Cayabyab FS, Zhou N, MacVicar BA. p38 mitogen-activated protein kinase contributes to adenosine A1 receptor-mediated synaptic depression in area CA1 of the rat hippocampus. J Neurosci 2006;26:12427-12438.
38. Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the [beta]2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997;390:88-91.
39. Faucher FA, Gannier FE, Lignon JM, Cosnay P, Malécot CO. Roles of PKA, PI3K and cPLA2 in the NO-mediated negative inotropic effect of [beta]2-adrenoceptor agonists in guinea pig right papillary muscles. Am J Physiol Cell Physiol 2008;294:C106-C117.
40. Mittra S, Bourreau JP. Gs and Gi coupling of adrenomedullin in adult rat ventricular myocytes. Am J Physiol 2006;290:H1842-H1847.