Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice

Cardiovascular Research

Volumn 82, Issue 1, 2009, Pages 93-99

  Mabe, Abigail M ^a   Hoover, Donald B ^a  

^a East Tennessee State University   (United States)

Author keywords

Autonomic nervous system; Bradycardia; Intrinsic cardiac neuron; Neurotrophic factors; Parasympathetic

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; NEURTURIN;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CHOLINERGIC ACTIVITY; CHOLINERGIC NERVE; CHOLINERGIC SYNAPSE; CHRONOTROPISM; ENZYME ACTIVITY; ENZYME HISTOCHEMISTRY; GENE DELETION; HEART; HEART ATRIUM; HEART FUNCTION; HEART RATE; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL; NERVE STIMULATION; NONHUMAN; NORADRENERGIC NERVE; NORADRENERGIC SYSTEM; PARASYMPATHETIC INNERVATION; PHENOTYPE; PRIORITY JOURNAL; SINUS NODE; VAGUS NERVE; VAGUS NERVE STIMULATION;

ACETYLCHOLINE; ADRENERGIC FIBERS; ANIMALS; BETHANECHOL; BRADYCARDIA; CARBACHOL; CHOLINERGIC AGONISTS; CHOLINERGIC FIBERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HEART; HEART ATRIA; HEART RATE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCARINIC AGONISTS; NEURTURIN; NOREPINEPHRINE; SINOATRIAL NODE; TIME FACTORS; VAGUS NERVE;

EID: 62349097794     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp029     Document Type: Article

References (24)

1. Ruit KG, Osborne PA, Schmidt RE, Johnson EM Jr, Snider WD. Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse. J Neurosci 1990;10:2412-2419.
2. Kaye DM, Vaddadi G, Gruskin SL, Du XJ, Esler MD. Reduced myocardial nerve growth factor expression in human and experimental heart failure. Circ Res 2000;86:E80-E84.
3. Qin F, Vulapalli RS, Stevens SY, Liang CS. Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF. Am J Physiol Heart Circ Physiol 2002;282:H363-H371.
4. Chen LS, Zhou S, Fishbein MC, Chen PS. New perspectives on the role of autonomic nervous system in the genesis of arrhythmias. J Cardiovasc Electrophysiol 2007;18:123-127.
5. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J et al. Nerve sprouting and sudden cardiac death. Circ Res 2000;86:816- 821.
6. Cao JM, Fishbein MC, Han JB, Lai WW, Lai AC, Wu TJ et al. Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation 2000;101:1960-1969.
7. Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM Jr et al. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature 1996;384:467-470.
8. Airaksinen MS, Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 2002;3:383-394.
9. Hiltunen JO, Laurikainen A, Airaksinen MS, Saarma M. GDNF family receptors in the embryonic and post-natal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRα2. Dev Dyn 2000;219:28-39.
10. Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A et al. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron 1999;22:253-263.
11. Mabe AM, Hoard JL, Duffourc MM, Hoover DB. Localization of cholinergic innervation and neurturin receptors in adult mouse heart and expression of the neurturin gene. Cell Tissue Res 2006;326:57-67.
12. Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N. Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75. Neuroscience 2008;156:129-142.
13. Koelle GB. The histochemical identification of acetylcholinesterase in cholinergic, adrenergic, and sensory neurons. J Pharmacol Exp Ther 1955;114:167-184.
14. Hancock JC, Hoover DB, Hougland MW. Distribution of muscarinic receptors and acetylcholinesterase in the rat heart. J Auton Nerv Syst 1987;19:59-66.
15. Hoover DB, Ganote CE, Ferguson SM, Blakely RD, Parsons RL. Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovasc Res 2004;62:112- 121.
16. Bertrand N, Beley P, Beley A. Brain fixation for acetylcholine measurements. J Neurosci Methods 1994;53:81-85.
17. Golden JP, DeMaro JA, Osborne PA, Milbrandt J, Johnson EM Jr. Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Exp Neurol 1999;158:504-528.
18. Wanigasekara Y, Keast JR. Neurturin has multiple neurotrophic effects on adult rat sacral parasympathetic ganglion neurons. Eur J Neurosci 2005;22:595-604.
19. Lommatzsch M, Quarcoo D, Schelte-Herbrüggen O, Weber H, Virchow JC, Renz H et al. Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood. Int J Dev Neurosci 2005;23:495-500.
20. Hiltunen JO, Arumae U, Moshnyakov M, Saarma M. Expression of mRNAs for neurotrophins and their receptors in developing rat heart. Circ Res 1996;79:930-939.
21. Westfall TC, Westfall DP. Neurotransmission. The autonomic and somatic motor nervous systems. In: Brunton LL, Lazo JS, Parker KL, ed. Goodman & Gilman's The Pharmacological basis of Therapeutics. 11th ed. New York: McGraw-Hill; 2006. p.137-181.
22. Corey SE, McPhillips JJ. Supersensitivity to the negative chronotopic action of carbachol and methacholine in the rat. Br J Pharmacol 1972;44:586-588.
23. Gehrmann J, Hammer PE, Maguire CT, Wakimoto H, Triedman JK, Berul CI. Phenotypic screening for heart rate variability in the mouse. Am J Physiol Heart Circ Physiol 2000;279:H733-H740.
24. Shusterman V, Usiene I, Harrigal C, Lee JS, Kubota T, Feldman AM et al. Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice. Am J Physiol Heart Circ Physiol 2002;282:H2076-H2083.