Biochemical Alterations in Partial Bladder Outlet Obstruction in Mice: Up-Regulation of the Mitogen Activated Protein Kinase Pathway

Journal of Urology

Volumn 181, Issue 4, 2009, Pages 1926-1931

  Myers, Jeremy B ^a   Dall'Era, Joseph E ^a   Koul, Sweaty ^a   Kumar, Binod ^a   Khandrika, Lakshmipathi ^a   Flynn, Brian J ^a   Koul, Hari K ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

mice; mitogen activated protein kinases; prostatic hyperplasia; Sprague Dawley; urinary bladder; urinary bladder neck obstruction

Indexed keywords

CYCLIN D3; CYCLINE; HEAT SHOCK PROTEIN 70; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER NECK STENOSIS; BODY WEIGHT; CONTROLLED STUDY; EXPERIMENTAL MOUSE; FEMALE; HISTOPATHOLOGY; MITOSIS RATE; MOUSE; NONHUMAN; ORGAN WEIGHT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SHAM PROCEDURE; UPREGULATION;

ANIMALS; FEMALE; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; UP-REGULATION; URINARY BLADDER NECK OBSTRUCTION;

EID: 62349083359     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2008.11.077     Document Type: Article

References (18)

1. Wei J.T., Calhoun E., and Jacobsen S.J. Urologic Diseases in America Project: benign prostatic hyperplasia. J Urol 173 (2005) 1256
2. Levin R.M., Brading A.F., Mills I.W., and Longhurst P.A. Experimental models of bladder outlet obstruction. In: Lepor H. (Ed). Prostatic Diseases (2000), WB Saunders Co, Philadelphia 169
3. Lemack G.E., Burkhard F., Zimmern P.E., McConnell J.D., and Lin V.K. Physiologic sequelae of partial infravesical obstruction in the mouse: role of inducible nitric oxide synthase. J Urol 161 (1999) 1015
4. Lemack G.E., Szabo Z., Urban Z., Boyd C.D., Csiszar K., Vaughan E.D., et al. Altered bladder function in transgenic mice expressing rat elastin. Neurourol Urodyn 18 (1999) 55
5. Lemack G.E., Zimmern P.E., Vazquez D., Mcconnell J.D., and Lin V.K. Altered response to partial outlet obstruction in mice lacking inducible nitric oxide synthase. J Urol 163 (2000) 1981
6. Pandita R.K., Fujiwara M., Alm P., and Andersson K.E. Cystometric evaluation of bladder function in non-anesthetized mice with and without bladder outlet obstruction. J Urol 164 (2000) 1385
7. Austin J.C., Chacko S.K., DiSanto M., Canning D.A., and Zderic S.A. A male murine model of partial outlet obstruction reveals changes in detrusor morphology, contractility and myosin isoform expression. J Urol 172 (2004) 1524
8. Bassuk J.A., Grady R., and Mitchel M. The molecular era of bladder research. Transgenic mice as experimental tools in the study of outlet obstruction. J Urol 164 (2000) 170
9. Pearson G., Robinson F., Beers G., Bing-e X., Karandikar M., Berman K., et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiologic functions. Endocrine Rev 22 (2001) 153
10. Jaal J., and Dorr W. Radiation induced inflammatory changes in the mouse bladder: the role of cyclooxygenase-2. J Urol 175 (2006) 1529
11. Yamaguchi O. Response of bladder smooth muscle cells to obstruction: signal transduction and the role of mechanosensors. Urology 63 (2004) 11
12. +2 in JNK activation by mechanical stretch in bladder smooth muscle cells. Am J Physiol Cell Physiol 281 (2001) 1165
13. Uvelius B., Persson L., and Mattiasson A. Smooth muscle hypertrophy and hyperplasia in the rat detrusor after short-term infravesical outflow obstruction. J Urol 131 (1984) 173
14. Mattiasson A., and Uvelius B. Changes in contractile properties in hypertrophic rat urinary bladder. J Urol 128 (1982) 1340
15. Flynn B.J., Mian H.S., Cera P.J., Kabler R.L., Mowad J.J., Cavanaugh A.H., et al. Early molecular changes in bladder hypertrophy due to bladder outlet obstruction. Urology 59 (2002) 978
16. Batts T.W., Klausner A.P., Jin Z., Meeks M.K., Ripley M.L., Yang S.K., et al. Increased expression of heat shock protein 20 and decreased contractile stress in obstructed rat bladder. J Urol 176 (2006) 1679
17. Zhao Y., Wein A.J., and Levin R.M. Assessment of stress gene messenger-RNA's (Hsp-27, Hsp-60 and Hsp-70) in obstructed rabbit urinary-bladder using a semiquantitative RT-PCR method. Mol Cell Biochem 148 (1995) 1
18. Johansson R., Pandita R.K., Poljakovic M., Garcia-pascual A., DeVente J., Persson K., et al. Activity and expression of nitric oxide synthase in the hypertrophied rat bladder and the effect of nitric oxide on bladder smooth muscle growth. J Urol 168 (2002) 2689