Occult bacteremia in the post-pneumococcal conjugate vaccine era: Does the blood culture stop here?

Academic Emergency Medicine

Volumn 16, Issue 3, 2009, Pages 258-260

  Avner, Jeffrey R ^a   Baker, M Douglas ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE; PNEUMOCOCCUS VACCINE;

ANTIBIOTIC THERAPY; BACTEREMIA; BLOOD ANALYSIS; BLOOD CULTURE; CLINICAL PRACTICE; COST EFFECTIVENESS ANALYSIS; EMERGENCY MEDICINE; EMERGENCY WARD; FEVER; HAEMOPHILUS INFLUENZAE TYPE B; HEALTH CARE; HUMAN; IMMUNIZATION; INCIDENCE; INFECTION RISK; NEISSERIA MENINGITIDIS; NOTE; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SEROTYPE; VACCINATION;

ANTI-BACTERIAL AGENTS; BACTEREMIA; BACTERIOLOGICAL TECHNIQUES; CHILD, PRESCHOOL; EMERGENCY SERVICE, HOSPITAL; FEVER; HOSPITALS, PEDIATRIC; HUMANS; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES;

EID: 62249205866     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1553-2712.2008.00345.x     Document Type: Note

References (16)

1. Burke JP, Klein JO, Gezon HM, Finland M. Pneumococcal bacteremia. Review of 111 cases, 1957-1969, with special reference to cases with undetermined focus. Am J Dis Child. 1971; 121:353-9.
2. McGowan JE Jr, Bratton L, Klein JO, Finland M. Bacteremia in febrile children seen in a "walk-in" pediatric clinic. N Engl J Med. 1973; 288:1309-12.
3. Teele DW, Pelton SI, Grant MJ, et al. Bacteremia in febrile children under 2 years of age: results of cultures of blood of 600 consecutive febrile children seen in a "walk-in" clinic. J Pediatr. 1975; 87:227-30.
4. Baraff LJ, Bass JW, Fleisher GR, et al. Practice guideline for the management of infants and children 0 to 36 months of age with fever without source. Agency for Health Care Policy and Research. Ann Emerg Med. 1993; 22:1198-210.
5. Fleisher GR, Rosenberg N, Vinci R, et al. Intramuscular versus oral antibiotic therapy for the prevention of meningitis and other bacterial sequelae in young, febrile children at risk for occult bacteremia. J Pediatr. 1994; 00:124504-12.
6. Jaffe DM, Tanz RR, Davis AT, Henretig F, Fleisher G. Antibiotic administration to treat possible occult bacteremia in febrile children. N Engl J Med. 1987; 317:1175-80.
7. Alpern ER, Alessandrini EA, Bell LM, Shaw KN, McGowan KL. Occult bacteremia from a pediatric emergency department: current prevalence, time to detection, and outcome. Pediatrics. 2000; 106:505-11.
8. Lee GM, Harper MB. Risk of bacteremia for febrile young children in the post-Haemophilus influenzae type b era. Arch Pediatr Adolesc Med. 1998; 152:624-8.
9. Klein JO. Management of the febrile child without a focus of infection in the era of universal pneumococcal immunization. Pediatr Infect Dis J. 2002; 21:584-8.
10. Alpern ER, Alessandrini EA, McGowan KL, Bell LM, Shaw KN. Serotype prevalence of occult pneumococcal bacteremia. Pediatrics. 2001; 108:E23.
11. Meltzer A, Powell K, Avner JR. Fever in infants and children. Consens Pediatr. 2005; 1:1-19.
12. Lee GM, Fleisher GR, Harper MB. Management of febrile children in the age of the conjugate pneumococcal vaccine: a cost-effectiveness analysis. Pediatrics. 2001; 108:835-44.
13. Avner JR, Baker MD. Management of fever in infants and children. Emerg Med Clin North Am. 2002; 20:49-67.
14. Wilkinson M, Bulloch B, Smith M. Prevalence of occult bacteremia in children aged 3 to 36 months presenting to the emergency department with fever in the postpneumococcal conjugate vaccine era. Acad Emerg Med. 2009; 16:220-225.
15. Carstairs KL, Tanen DA, Johnson AS, Kailes SB, Riffenburgh RH. Pneumococcal bacteremia in febrile infants presenting to the emergency department before and after the introduction of the heptavalent pneumococcal vaccine. Ann Emerg Med. 2007; 49:772-7.
16. Herz AM, Greenhow TL, Alcantara J, et al. Changing epidemiology of outpatient bacteremia in 3- to 36-month-old children after the introduction of the heptavalent-conjugated pneumococcal vaccine. Pediatr Infect Dis J. 2006; 25:293-300.