Simultaneous determination of 6R-leucovorin, 6S-leucovorin and 5-methyltetrahydrofolate in human plasma using solid phase extraction and chiral liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 10, 2009, Pages 902-910

  Liu, Ke ^a   Dai, Xiaojian ^a   Zhong, Dafang ^a   Deng, Pan ^a   Ma, Jinfei ^a   Chen, Xiaoyan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

5 Methyltetrahydrofolate; LC MS MS; Leucovorin; Stereoselective separation

Indexed keywords

BODY FLUIDS; CALCIUM; CALCIUM ALLOYS; CHIRALITY; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOMERS; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS; PLASMA (HUMAN); SEPARATION; SOLVENT EXTRACTION; SPECTRUM ANALYSIS;

5-METHYLTETRAHYDROFOLATE; ANALYTES; CALIBRATION CURVES; CHIRAL LIQUID CHROMATOGRAPHIES; CHIRAL SEPARATIONS; HUMAN PLASMAS; INTER-ASSAY PRECISION; INTERNAL STANDARDS; LC-MS/MS; LEUCOVORIN; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRIES; LOWER LIMIT OF QUANTIFICATIONS; MACROCYCLIC GLYCOPEPTIDE; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC STUDIES; POSITIVE ELECTROSPRAY IONIZATIONS; RAPID METHODS; SIMULTANEOUS DETERMINATIONS; SOLID-PHASE EXTRACTIONS; STEREOSELECTIVE SEPARATION; TEICOPLANIN;

PLASMAS;

5 METHYLTETRAHYDROFOLIC ACID; FOLINIC ACID;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; DIASTEREOISOMER; DRUG DETERMINATION; ELECTROSPRAY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; SPECTROMETER; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; HUMANS; LEUCOVORIN; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TETRAHYDROFOLATES;

EID: 62249176915     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.02.046     Document Type: Article

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