메뉴 건너뛰기




Volumn 10, Issue 2, 2009, Pages 137-149

Current developments in anti-HIV/AIDS gene therapy

Author keywords

Cellular factor; Decoy; Dominant negative; Lentiviral vector; Ribozyme; RNAi

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; COMPLEMENTARY RNA; DOXYCYCLINE; ENFUVIRTIDE; LAMIVUDINE; LENTIVIRUS VECTOR; MAC46 PROTEIN; MIR 32 VECTOR; RETROVIRUS VECTOR; REV PROTEIN; RIBOZYME; SHORT HAIRPIN RNA; SINGLE STRANDED DNA; SIVMAC 251 VECTOR; T LYMPHOCYTE RECEPTOR; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRIPARTITE MOTIF PROTEIN 5; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN; VIRUS VECTOR;

EID: 62249171613     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (15)

References (152)
  • 1
    • 30744458345 scopus 로고    scopus 로고
    • Gene therapy for HIV-1 infection: Are lethal genes a valuable tool?
    • Luque F, Oya R, Macias D, Saniger L: Gene therapy for HIV-1 infection: Are lethal genes a valuable tool? Cell Mol Biol (2005) 51(1):93-101.
    • (2005) Cell Mol Biol , vol.51 , Issue.1 , pp. 93-101
    • Luque, F.1    Oya, R.2    Macias, D.3    Saniger, L.4
  • 2
    • 33745646047 scopus 로고    scopus 로고
    • Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome
    • Dropulic B, June CH: Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome. Hum Gene Ther (2006) 17(6):577-588.
    • (2006) Hum Gene Ther , vol.17 , Issue.6 , pp. 577-588
    • Dropulic, B.1    June, C.H.2
  • 3
    • 33646921719 scopus 로고    scopus 로고
    • Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infection
    • Morris KV, Rossi JJ: Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infection. Hum Gene Ther (2006) 17(5):479-486.
    • (2006) Hum Gene Ther , vol.17 , Issue.5 , pp. 479-486
    • Morris, K.V.1    Rossi, J.J.2
  • 4
    • 33745258996 scopus 로고    scopus 로고
    • Gene therapy for HIV infection: What does it need to make it work?
    • von Laer D, Hasselmann S, Hasselmann K: Gene therapy for HIV infection: What does it need to make it work? J Gene Med (2006) 8(6):658-667.
    • (2006) J Gene Med , vol.8 , Issue.6 , pp. 658-667
    • von Laer, D.1    Hasselmann, S.2    Hasselmann, K.3
  • 7
    • 0242383496 scopus 로고    scopus 로고
    • Worldwide transmission of drug-resistant HIV
    • Wensing AM, Boucher CA: Worldwide transmission of drug-resistant HIV. AIDS Rev (2003) 5(3):140-155.
    • (2003) AIDS Rev , vol.5 , Issue.3 , pp. 140-155
    • Wensing, A.M.1    Boucher, C.A.2
  • 13
    • 33645144814 scopus 로고    scopus 로고
    • Lentiviral-mediated delivery of siRNAs for antiviral therapy
    • Morris KV, Rossi JJ: Lentiviral-mediated delivery of siRNAs for antiviral therapy. Gene Ther (2006) 13(6):553-558.
    • (2006) Gene Ther , vol.13 , Issue.6 , pp. 553-558
    • Morris, K.V.1    Rossi, J.J.2
  • 14
    • 37249086660 scopus 로고    scopus 로고
    • Gene therapy to induce cellular resistance to HIV-1 infection: Lessons from clinical trials
    • Giacca M: Gene therapy to induce cellular resistance to HIV-1 infection: Lessons from clinical trials. Adv Pharmacol (2008) 56:297-325.
    • (2008) Adv Pharmacol , vol.56 , pp. 297-325
    • Giacca, M.1
  • 15
    • 0024382709 scopus 로고
    • Functional dissection of the HIV-1 Rev trans-activator - derivation of a transdominant repressor of Rev function
    • Malim MH, Bohnlein S, Hauber J, Cullen BR: Functional dissection of the HIV-1 Rev trans-activator - derivation of a transdominant repressor of Rev function. Cell (1989) 58(1):205-214.
    • (1989) Cell , vol.58 , Issue.1 , pp. 205-214
    • Malim, M.H.1    Bohnlein, S.2    Hauber, J.3    Cullen, B.R.4
  • 16
    • 0032477912 scopus 로고    scopus 로고
    • Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals
    • Ranga U, Woffendin C, Verma S, Xu L, June CH, Bishop DK, Nabel GJ: Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals. Proc Natl Acad Sci USA (1998) 95(3):1201-1206.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.3 , pp. 1201-1206
    • Ranga, U.1    Woffendin, C.2    Verma, S.3    Xu, L.4    June, C.H.5    Bishop, D.K.6    Nabel, G.J.7
  • 18
    • 33845994066 scopus 로고    scopus 로고
    • Lentiviral vector transduction of a dominant-negative Rev gene into human CD34+ hematopoietic progenitor cells potently inhibits human immunodeficiency virus-1 replication
    • Bahner I, Sumiyoshi T, Kagoda M, Swartout R, Peterson D, Pepper K, Dorey F, Reiser J, Kohn DB: Lentiviral vector transduction of a dominant-negative Rev gene into human CD34+ hematopoietic progenitor cells potently inhibits human immunodeficiency virus-1 replication. Mol Ther (2007) 15(1):76-85.
    • (2007) Mol Ther , vol.15 , Issue.1 , pp. 76-85
    • Bahner, I.1    Sumiyoshi, T.2    Kagoda, M.3    Swartout, R.4    Peterson, D.5    Pepper, K.6    Dorey, F.7    Reiser, J.8    Kohn, D.B.9
  • 21
    • 34247208235 scopus 로고    scopus 로고
    • Lunzen J, Glaunsinger T, Stahmer I, Baehr V, Baum C, Schilz A, Kuehlcke K, Naundorf S, Martinius H, Hermann F, Giroglou T et al: Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol Ther (2007) 15(5):1024-1033. • Infusion of autologous T-cells transduced to express a membrane-anchored peptide that inhibited HIV-1 cell fusion was safe and correlated with beneficial effects in patients with advanced-stage AIDS.
    • Lunzen J, Glaunsinger T, Stahmer I, Baehr V, Baum C, Schilz A, Kuehlcke K, Naundorf S, Martinius H, Hermann F, Giroglou T et al: Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus. Mol Ther (2007) 15(5):1024-1033. • Infusion of autologous T-cells transduced to express a membrane-anchored peptide that inhibited HIV-1 cell fusion was safe and correlated with beneficial effects in patients with advanced-stage AIDS.
  • 22
    • 0141521594 scopus 로고    scopus 로고
    • Novel interfering bifunctional molecules against the CCR5 coreceptor are efficient inhibitors of HIV-1 infection
    • Luis Abad J, Gonzalez MA, del Real G, Mira E, Manes S, Serrano F, Bernad A: Novel interfering bifunctional molecules against the CCR5 coreceptor are efficient inhibitors of HIV-1 infection. Mol Ther (2003) 8(3):475-484.
    • (2003) Mol Ther , vol.8 , Issue.3 , pp. 475-484
    • Luis Abad, J.1    Gonzalez, M.A.2    del Real, G.3    Mira, E.4    Manes, S.5    Serrano, F.6    Bernad, A.7
  • 25
    • 0141655245 scopus 로고    scopus 로고
    • 1-antitrypsin inhibition of cellular serine proteases and HIV-1 protease that are essential for HIV-1 morphogenesis
    • 1-antitrypsin inhibition of cellular serine proteases and HIV-1 protease that are essential for HIV-1 morphogenesis. Biochim Biophys Acta (2003) 1638(3):197-207.
    • (2003) Biochim Biophys Acta , vol.1638 , Issue.3 , pp. 197-207
    • Cordelier, P.1    Strayer, D.S.2
  • 26
    • 0347407801 scopus 로고    scopus 로고
    • 1-antitrypsin delivered by recombinant SV40 vectors protects lymphocytes against HIV
    • 1-antitrypsin delivered by recombinant SV40 vectors protects lymphocytes against HIV. Gene Ther (2003) 10(26):2153-2156.
    • (2003) Gene Ther , vol.10 , Issue.26 , pp. 2153-2156
    • Cordelier, P.1    Strayer, D.S.2
  • 27
    • 33646053800 scopus 로고    scopus 로고
    • Using gene delivery to protect HIV-susceptible CNS cells: Inhibiting HIV replication in microglia
    • Cordelier P, Strayer DS: Using gene delivery to protect HIV-susceptible CNS cells: Inhibiting HIV replication in microglia. Virus Res (2006) 118(1-2):87-97.
    • (2006) Virus Res , vol.118 , Issue.1-2 , pp. 87-97
    • Cordelier, P.1    Strayer, D.S.2
  • 30
    • 0037630009 scopus 로고    scopus 로고
    • Comprehensive investigation of the molecular defect in Vif-deficient human immunodeficiency virus type 1 virions
    • Gaddis NC, Chertova E, Sheehy AM, Henderson LE, Malim MH: Comprehensive investigation of the molecular defect in Vif-deficient human immunodeficiency virus type 1 virions. J Virol (2003) 77(10):5810-5820.
    • (2003) J Virol , vol.77 , Issue.10 , pp. 5810-5820
    • Gaddis, N.C.1    Chertova, E.2    Sheehy, A.M.3    Henderson, L.E.4    Malim, M.H.5
  • 31
    • 0038363470 scopus 로고    scopus 로고
    • Hypermutation of HIV-1 DNA in the absence of the Vif protein
    • Lecossier D, Bouchonnet F, Clavel F, Hance AJ: Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science (2003) 300(5622):1112.
    • (2003) Science , vol.300 , Issue.5622 , pp. 1112
    • Lecossier, D.1    Bouchonnet, F.2    Clavel, F.3    Hance, A.J.4
  • 32
    • 0038004471 scopus 로고    scopus 로고
    • The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA
    • Zhang H, Yang B, Pomerantz RJ, Zhang C, Arunachalam SC, Gao L: The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Nature (2003) 424(6944):94-98.
    • (2003) Nature , vol.424 , Issue.6944 , pp. 94-98
    • Zhang, H.1    Yang, B.2    Pomerantz, R.J.3    Zhang, C.4    Arunachalam, S.C.5    Gao, L.6
  • 33
    • 0038681023 scopus 로고    scopus 로고
    • Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
    • Mangeat B, Turelli P, Caron G, Friedli M, Perrin L, Trono D: Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts. Nature (2003) 424(6944):99-103.
    • (2003) Nature , vol.424 , Issue.6944 , pp. 99-103
    • Mangeat, B.1    Turelli, P.2    Caron, G.3    Friedli, M.4    Perrin, L.5    Trono, D.6
  • 35
    • 33748640960 scopus 로고    scopus 로고
    • Antiviral potency of APOBEC proteins does not correlate with cytidine deamination
    • Bishop KN, Holmes RK, Malim MH: Antiviral potency of APOBEC proteins does not correlate with cytidine deamination. J Virol (2006) 80(17):8450-8458.
    • (2006) J Virol , vol.80 , Issue.17 , pp. 8450-8458
    • Bishop, K.N.1    Holmes, R.K.2    Malim, M.H.3
  • 36
    • 3242720240 scopus 로고    scopus 로고
    • Trim5α protein restricts both HIV-1 and murine leukemia virus
    • Yap MW, Nisole S, Lynch C, Stoye JP: Trim5α protein restricts both HIV-1 and murine leukemia virus. Proc Natl Acad Sci USA (2004) 101(29):10786-10791.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.29 , pp. 10786-10791
    • Yap, M.W.1    Nisole, S.2    Lynch, C.3    Stoye, J.P.4
  • 37
    • 21644450071 scopus 로고    scopus 로고
    • Human tripartite motif 5α domains responsible for retrovirus restriction activity and specificity
    • Perez-Caballero D, Hatziioannou T, Yang A, Cowan S, Bieniasz PD: Human tripartite motif 5α domains responsible for retrovirus restriction activity and specificity. J Virol (2005) 79(14):8969-8978.
    • (2005) J Virol , vol.79 , Issue.14 , pp. 8969-8978
    • Perez-Caballero, D.1    Hatziioannou, T.2    Yang, A.3    Cowan, S.4    Bieniasz, P.D.5
  • 39
    • 1542288934 scopus 로고    scopus 로고
    • The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
    • Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J: The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys. Nature (2004) 427(6977):848-853.
    • (2004) Nature , vol.427 , Issue.6977 , pp. 848-853
    • Stremlau, M.1    Owens, C.M.2    Perron, M.J.3    Kiessling, M.4    Autissier, P.5    Sodroski, J.6
  • 40
    • 13944259674 scopus 로고    scopus 로고
    • SPRY domain of TRIM5α determines the potency of human immunodeficiency virus restriction
    • SPRY domain of TRIM5α determines the potency of human immunodeficiency virus restriction. J Virol (2005) 79(5):3139-3145.
    • (2005) J Virol , vol.79 , Issue.5 , pp. 3139-3145
    • Stremlau, M.1    Perron, M.2    Welikala, S.3    Sodroski, J.4
  • 41
    • 14544281087 scopus 로고    scopus 로고
    • Positive selection of primate TRIM5α identifies a critical species-specific retroviral restriction domain
    • Sawyer SL, Wu LI, Emerman M, Malik HS: Positive selection of primate TRIM5α identifies a critical species-specific retroviral restriction domain. Proc Natl Acad Sci USA (2005) 102(8):2832-2837.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.8 , pp. 2832-2837
    • Sawyer, S.L.1    Wu, L.I.2    Emerman, M.3    Malik, H.S.4
  • 42
    • 33845989508 scopus 로고    scopus 로고
    • Sakuma R, Noser JA, Ohmine S, Ikeda Y: Inhibition of HIV-1 replication by simian restriction factors, TRIM5α and APOBEC3G. Gene Ther (2007) 14(2):185-189. • Although expression of APOBEC3G affected HIV-1 replication only transiently and only at low viral doses, APOBEC3G substantially potentiated the antiviral effect of TRIM5α.
    • Sakuma R, Noser JA, Ohmine S, Ikeda Y: Inhibition of HIV-1 replication by simian restriction factors, TRIM5α and APOBEC3G. Gene Ther (2007) 14(2):185-189. • Although expression of APOBEC3G affected HIV-1 replication only transiently and only at low viral doses, APOBEC3G substantially potentiated the antiviral effect of TRIM5α.
  • 43
    • 41149134501 scopus 로고    scopus 로고
    • Anderson J, Akkina R: Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5α (TRIM 5α) in CD34+ cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue. Hum Gene Ther (2008) 19(3):217-228.
    • Anderson J, Akkina R: Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5α (TRIM 5α) in CD34+ cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue. Hum Gene Ther (2008) 19(3):217-228.
  • 44
    • 33846809447 scopus 로고    scopus 로고
    • Primitive hematopoietic cells resist HIV-1 infection via p21
    • The cyclin-dependent kinase inhibitor p21 restricted HIV-1 infection independently of its general effect on cell cycling, suggesting that it may be a potential anti-HIV/AIDS gene therapy target, ••
    • Zhang J, Scadden DT, Crumpacker CS: Primitive hematopoietic cells resist HIV-1 infection via p21. J Clin Invest (2007) 117(2):473-481. •• The cyclin-dependent kinase inhibitor p21 restricted HIV-1 infection independently of its general effect on cell cycling, suggesting that it may be a potential anti-HIV/AIDS gene therapy target.
    • (2007) J Clin Invest , vol.117 , Issue.2 , pp. 473-481
    • Zhang, J.1    Scadden, D.T.2    Crumpacker, C.S.3
  • 45
    • 0033544331 scopus 로고    scopus 로고
    • Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express Herpesvirus saimiri proteins StpC and/or Tip
    • Henderson EE, Tsygankov AY, Merlo JJ, Romano G, Guan M: Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express Herpesvirus saimiri proteins StpC and/or Tip. Virology (1999) 264(1):125-133.
    • (1999) Virology , vol.264 , Issue.1 , pp. 125-133
    • Henderson, E.E.1    Tsygankov, A.Y.2    Merlo, J.J.3    Romano, G.4    Guan, M.5
  • 46
    • 2942527159 scopus 로고    scopus 로고
    • Herpesvirus saimiri-encoded proteins Tip and StpC modulate human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes independently of viral tropism
    • Raymond AD, Hasham MG, Tsygankov AY, Henderson EE: Herpesvirus saimiri-encoded proteins Tip and StpC modulate human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes independently of viral tropism. Virology (2004) 324(1):60-66.
    • (2004) Virology , vol.324 , Issue.1 , pp. 60-66
    • Raymond, A.D.1    Hasham, M.G.2    Tsygankov, A.Y.3    Henderson, E.E.4
  • 47
    • 33747035823 scopus 로고    scopus 로고
    • Raymond AD, Hasham M, Tsygankov AY, Henderson EE: H. saimiri tyrosine-kinase interacting protein inhibits Tat function: A prototypic strategy for restricting HIV-1-induced cytopathic effects in immune cells. Virology (2006) 352(2):253-267.
    • Raymond AD, Hasham M, Tsygankov AY, Henderson EE: H. saimiri tyrosine-kinase interacting protein inhibits Tat function: A prototypic strategy for restricting HIV-1-induced cytopathic effects in immune cells. Virology (2006) 352(2):253-267.
  • 48
    • 33846092269 scopus 로고    scopus 로고
    • Herpesvirus saimiri terminal membrane proteins modulate HIV-1 replication by altering Nef and Tat functions
    • Raymond AD, Hasham M, Tsygankov AY, Henderson EE: Herpesvirus saimiri terminal membrane proteins modulate HIV-1 replication by altering Nef and Tat functions. Curr HIV Res (2007) 5(1):79-86.
    • (2007) Curr HIV Res , vol.5 , Issue.1 , pp. 79-86
    • Raymond, A.D.1    Hasham, M.2    Tsygankov, A.Y.3    Henderson, E.E.4
  • 49
    • 16344377458 scopus 로고    scopus 로고
    • Cell transformation by Herpesvirus saimiri
    • Tsygankov AY: Cell transformation by Herpesvirus saimiri. J Cell Physiol (2005) 203(2):305-318.
    • (2005) J Cell Physiol , vol.203 , Issue.2 , pp. 305-318
    • Tsygankov, A.Y.1
  • 53
    • 3242707674 scopus 로고    scopus 로고
    • Intracellular antibodies as specific reagents for functional ablation: Future therapeutic molecules
    • Lobato MN, Rabbitts TH: Intracellular antibodies as specific reagents for functional ablation: Future therapeutic molecules. Curr Mol Med (2004) 4(5):519-528.
    • (2004) Curr Mol Med , vol.4 , Issue.5 , pp. 519-528
    • Lobato, M.N.1    Rabbitts, T.H.2
  • 54
    • 0037199960 scopus 로고    scopus 로고
    • Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication
    • Goncalves J, Silva F, Freitas-Vieira A, Santa-Marta M, Malhó R, Yang X, Gabuzda D, Barbas C 3rd: Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication. J Biol Chem (2002) 277(35):32036-32045.
    • (2002) J Biol Chem , vol.277 , Issue.35 , pp. 32036-32045
    • Goncalves, J.1    Silva, F.2    Freitas-Vieira, A.3    Santa-Marta, M.4    Malhó, R.5    Yang, X.6    Gabuzda, D.7    Barbas 3rd, C.8
  • 55
    • 0035078877 scopus 로고    scopus 로고
    • Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4
    • BouHamdan M, Strayer DS, Wei D, Mukhtar M, Duan LX, Hoxie J, Pomerantz RJ: Inhibition of HIV-1 infection by down-regulation of the CXCR4 co-receptor using an intracellular single chain variable fragment against CXCR4. Gene Ther (2001) 8(5):408-418.
    • (2001) Gene Ther , vol.8 , Issue.5 , pp. 408-418
    • BouHamdan, M.1    Strayer, D.S.2    Wei, D.3    Mukhtar, M.4    Duan, L.X.5    Hoxie, J.6    Pomerantz, R.J.7
  • 58
    • 23844524700 scopus 로고    scopus 로고
    • Intracellular antibodies (intrabodies) versus RNA interference for therapeutic applications
    • Cao T, Heng BC: Intracellular antibodies (intrabodies) versus RNA interference for therapeutic applications. Ann Clin Lab Sci (2005) 35(3):227-229.
    • (2005) Ann Clin Lab Sci , vol.35 , Issue.3 , pp. 227-229
    • Cao, T.1    Heng, B.C.2
  • 59
    • 46249106228 scopus 로고    scopus 로고
    • Hammer D, Wild J, Ludwig C, Asbach B, Notka F, Wagner R: Fusion of Epstein-Barr virus nuclear antigen-1-derived glycine-alanine repeat to trans-dominant HIV-1 Gag increases inhibitory activities and survival of transduced cells in vivo. Hum Gene Ther (2008) 19(6):622-634. • Fusion of vector-expressed transdominant Gag to a sequence that negatively regulates proteasomal degradation increased the stability of chimeric Gag and its anti-HIV inhibitory properties. The in vivo immune response against cells expressing this form of Gag was decreased because of a reduction in the presentation of its antigenic peptides on the cell surface.
    • Hammer D, Wild J, Ludwig C, Asbach B, Notka F, Wagner R: Fusion of Epstein-Barr virus nuclear antigen-1-derived glycine-alanine repeat to trans-dominant HIV-1 Gag increases inhibitory activities and survival of transduced cells in vivo. Hum Gene Ther (2008) 19(6):622-634. • Fusion of vector-expressed transdominant Gag to a sequence that negatively regulates proteasomal degradation increased the stability of chimeric Gag and its anti-HIV inhibitory properties. The in vivo immune response against cells expressing this form of Gag was decreased because of a reduction in the presentation of its antigenic peptides on the cell surface.
  • 60
    • 42449121506 scopus 로고    scopus 로고
    • PKR in innate immunity, cancer, and viral oncolysis
    • Balachandran S, Barber GN: PKR in innate immunity, cancer, and viral oncolysis. Methods Mol Biol (2007) 383:277-301.
    • (2007) Methods Mol Biol , vol.383 , pp. 277-301
    • Balachandran, S.1    Barber, G.N.2
  • 61
    • 41649094382 scopus 로고    scopus 로고
    • Recognition of nucleic acid and nucleic acid analogs by toll-like receptors 7, 8 and 9
    • Bauer S, Pigisch S, Hangel D, Kaufmann A, Hamm S: Recognition of nucleic acid and nucleic acid analogs by toll-like receptors 7, 8 and 9. Immunobiology (2008) 213 (3-4):315-328.
    • (2008) Immunobiology , vol.213 , Issue.3-4 , pp. 315-328
    • Bauer, S.1    Pigisch, S.2    Hangel, D.3    Kaufmann, A.4    Hamm, S.5
  • 62
    • 84884581309 scopus 로고    scopus 로고
    • Toll-like receptors (TLRs) and their ligands
    • Uematsu S, Akira S: Toll-like receptors (TLRs) and their ligands. Handb Exp Pharmacol (2008) 183:1-20.
    • (2008) Handb Exp Pharmacol , vol.183 , pp. 1-20
    • Uematsu, S.1    Akira, S.2
  • 64
    • 39349090624 scopus 로고    scopus 로고
    • Nucleic acid recognition receptors in autoimmunity
    • Krug A: Nucleic acid recognition receptors in autoimmunity. Handbook Exp Pharmacol (2008) 183:129-151.
    • (2008) Handbook Exp Pharmacol , vol.183 , pp. 129-151
    • Krug, A.1
  • 66
    • 34250612325 scopus 로고    scopus 로고
    • Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus
    • Friedman DM, Rupel A, Buyon JP: Epidemiology, etiology, detection, and treatment of autoantibody-associated congenital heart block in neonatal lupus. Curr Rheumatol Rep (2007) 9(2):101-108.
    • (2007) Curr Rheumatol Rep , vol.9 , Issue.2 , pp. 101-108
    • Friedman, D.M.1    Rupel, A.2    Buyon, J.P.3
  • 67
    • 36148964059 scopus 로고    scopus 로고
    • Infections, B cell receptor activation and autoimmunity: Different check-point impairments lead to autoimmunity, clonal B cell expansion and fibrosis in different immunological settings
    • Ferraccioli G, Tolusso B: Infections, B cell receptor activation and autoimmunity: Different check-point impairments lead to autoimmunity, clonal B cell expansion and fibrosis in different immunological settings. Autoimmun Rev (2007) 7(2):109-113.
    • (2007) Autoimmun Rev , vol.7 , Issue.2 , pp. 109-113
    • Ferraccioli, G.1    Tolusso, B.2
  • 68
    • 4544301510 scopus 로고    scopus 로고
    • Immunogenicity of superoxide radical modified-DNA: Studies on induced antibodies and SLE anti-DNA autoantibodies
    • Waris G, Alam K: Immunogenicity of superoxide radical modified-DNA: Studies on induced antibodies and SLE anti-DNA autoantibodies. Life Sci (2004) 75(22):2633-2642.
    • (2004) Life Sci , vol.75 , Issue.22 , pp. 2633-2642
    • Waris, G.1    Alam, K.2
  • 69
    • 33747643450 scopus 로고    scopus 로고
    • Plasmid DNA acquires immunogenicity on exposure to singlet oxygen
    • Khan F, Siddiqui AA, Ali R: Plasmid DNA acquires immunogenicity on exposure to singlet oxygen. Biochemistry (Mosc) (2006) 71(8):871-878.
    • (2006) Biochemistry (Mosc) , vol.71 , Issue.8 , pp. 871-878
    • Khan, F.1    Siddiqui, A.A.2    Ali, R.3
  • 70
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 411(6836):494-498.
    • (2001) Nature , vol.411 , Issue.6836 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 71
    • 0036351317 scopus 로고    scopus 로고
    • Analysis of gene function in somatic mammalian cells using small interfering RNAs
    • Elbashir SM, Harborth J, Weber K, Tuschl T: Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods (2002) 26(2):199-213.
    • (2002) Methods , vol.26 , Issue.2 , pp. 199-213
    • Elbashir, S.M.1    Harborth, J.2    Weber, K.3    Tuschl, T.4
  • 72
    • 25144495252 scopus 로고    scopus 로고
    • Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells
    • Li M, Rossi JJ: Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells. Methods Mol Biol (2005) 309:261-272.
    • (2005) Methods Mol Biol , vol.309 , pp. 261-272
    • Li, M.1    Rossi, J.J.2
  • 73
    • 0028782293 scopus 로고
    • Evolution of mutation rate and virulence among human retroviruses
    • Ewald PW: Evolution of mutation rate and virulence among human retroviruses. Philos Trans R Soc Lond B Biol Sci (1994) 346(1317):333-341.
    • (1994) Philos Trans R Soc Lond B Biol Sci , vol.346 , Issue.1317 , pp. 333-341
    • Ewald, P.W.1
  • 74
    • 0029075130 scopus 로고
    • Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
    • Mansky LM, Temin HM: Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J Virol (1995) 69(8):5087- 5094.
    • (1995) J Virol , vol.69 , Issue.8 , pp. 5087-5094
    • Mansky, L.M.1    Temin, H.M.2
  • 76
    • 0033809519 scopus 로고    scopus 로고
    • In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy
    • Mansky LM: In vivo analysis of human T-cell leukemia virus type 1 reverse transcription accuracy. J Virol (2000) 74(20):9525-9531.
    • (2000) J Virol , vol.74 , Issue.20 , pp. 9525-9531
    • Mansky, L.M.1
  • 77
    • 0028843163 scopus 로고
    • Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959
    • Jacobsen H, Yasargil K, Winslow DL, Craig JC, Krohn A, Duncan IB, Mous J: Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959. Virology (1995) 206(1):527-534.
    • (1995) Virology , vol.206 , Issue.1 , pp. 527-534
    • Jacobsen, H.1    Yasargil, K.2    Winslow, D.L.3    Craig, J.C.4    Krohn, A.5    Duncan, I.B.6    Mous, J.7
  • 78
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder BA, Kemp SD: Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science (1989) 246(4934):1155-1158.
    • (1989) Science , vol.246 , Issue.4934 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 79
    • 0026036042 scopus 로고
    • Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes
    • Larder BA, Kellam P, Kemp SD: Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes. AIDS (1991) 5(2):137-144.
    • (1991) AIDS , vol.5 , Issue.2 , pp. 137-144
    • Larder, B.A.1    Kellam, P.2    Kemp, S.D.3
  • 82
    • 0028854676 scopus 로고
    • Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
    • Markowitz M, Mo H, Kempf DJ, Norbeck DW, Bhat TN, Erickson JW, Ho DD: Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J Virol (1995) 69(2):701-706.
    • (1995) J Virol , vol.69 , Issue.2 , pp. 701-706
    • Markowitz, M.1    Mo, H.2    Kempf, D.J.3    Norbeck, D.W.4    Bhat, T.N.5    Erickson, J.W.6    Ho, D.D.7
  • 83
    • 33845668311 scopus 로고    scopus 로고
    • Li M, Li H, Rossi JJ: RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapy. Ann NY Acad Sci (2006) 1082:172-179. • Human hematopoietic cells were completely protected against HIV-1 infection in vitro by a lentiviral vector encoding a Tat/Rev common exon shRNA, a ribozyme that degrades the CCR5 mRNA and a TAR decoy. The effect of this triple construct was greater than that of single and double constructs.
    • Li M, Li H, Rossi JJ: RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapy. Ann NY Acad Sci (2006) 1082:172-179. • Human hematopoietic cells were completely protected against HIV-1 infection in vitro by a lentiviral vector encoding a Tat/Rev common exon shRNA, a ribozyme that degrades the CCR5 mRNA and a TAR decoy. The effect of this triple construct was greater than that of single and double constructs.
  • 84
    • 30344474936 scopus 로고    scopus 로고
    • Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs
    • Sabariegos R, Gimenez-Barcons M, Tapia N, Clotet B, Martinez MA: Sequence homology required by human immunodeficiency virus type 1 to escape from short interfering RNAs. J Virol (2006) 80(2):571-577.
    • (2006) J Virol , vol.80 , Issue.2 , pp. 571-577
    • Sabariegos, R.1    Gimenez-Barcons, M.2    Tapia, N.3    Clotet, B.4    Martinez, M.A.5
  • 86
    • 29244433509 scopus 로고    scopus 로고
    • Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA
    • Akashi H, Miyagishi M, Yokota T, Watanabe T, Hino T, Nishina K, Kohara M, Taira K: Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA. Mol Biosyst (2005) 1(5-6):382-390.
    • (2005) Mol Biosyst , vol.1 , Issue.5-6 , pp. 382-390
    • Akashi, H.1    Miyagishi, M.2    Yokota, T.3    Watanabe, T.4    Hino, T.5    Nishina, K.6    Kohara, M.7    Taira, K.8
  • 88
    • 33751001588 scopus 로고    scopus 로고
    • ter Brake O, Konstantinova P, Ceylan M, Berkhout B: Silencing of HIV-1 with RNA interference: A multiple shRNA approach. Mol Ther (2006) 14(6):883-892. •• Multiple shRNAs targeting conserved HIV-1 regions were screened and the shRNAs that demonstrated the greatest inhibition of HIV-1 replication were expressed from a single lentiviral vector. Inhibition of HIV-1 replication was much greater when the shRNAs were expressed in combination compared with expression of single shRNAs.
    • ter Brake O, Konstantinova P, Ceylan M, Berkhout B: Silencing of HIV-1 with RNA interference: A multiple shRNA approach. Mol Ther (2006) 14(6):883-892. •• Multiple shRNAs targeting conserved HIV-1 regions were screened and the shRNAs that demonstrated the greatest inhibition of HIV-1 replication were expressed from a single lentiviral vector. Inhibition of HIV-1 replication was much greater when the shRNAs were expressed in combination compared with expression of single shRNAs.
  • 89
    • 34249336747 scopus 로고    scopus 로고
    • Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R: Safety and efficacy of a lentiviral vector containing three anti-HIV genes - CCR5 ribozyme, Tat-rev siRNA, and TAR decoy-in SCID-hu mouse-derived T cells. Mol Ther (2007) 15(6):1182-1188. •• Hematopoietic cells transduced with the triple lentiviral vector described in reference [83] successfully reconstituted human thymic grafts in SCID mice. The gene-modified thymocytes were resistant to HIV-1 challenge.
    • Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R: Safety and efficacy of a lentiviral vector containing three anti-HIV genes - CCR5 ribozyme, Tat-rev siRNA, and TAR decoy-in SCID-hu mouse-derived T cells. Mol Ther (2007) 15(6):1182-1188. •• Hematopoietic cells transduced with the triple lentiviral vector described in reference [83] successfully reconstituted human thymic grafts in SCID mice. The gene-modified thymocytes were resistant to HIV-1 challenge.
  • 91
    • 33751193683 scopus 로고    scopus 로고
    • Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages
    • Yamamoto T, Miyoshi H, Yamamoto N, Inoue J, Tsunetsugu-Yokota Y: Lentivirus vectors expressing short hairpin RNAs against the U3-overlapping region of HIV nef inhibit HIV replication and infectivity in primary macrophages. Blood (2006) 108(10):3305-3312.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3305-3312
    • Yamamoto, T.1    Miyoshi, H.2    Yamamoto, N.3    Inoue, J.4    Tsunetsugu-Yokota, Y.5
  • 92
    • 33746210111 scopus 로고    scopus 로고
    • Nishitsuji H, Kohara M, Kannagi M, Masuda T: Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J Virol (2006) 80(15):7658-7666. • Targeting of the integrase gene in combination with the U3 region of the attachment site suppressed HIV-1 replication more effectively than Tat-specific shRNA, suggesting that HIV-1 integration may be an effective therapeutic target.
    • Nishitsuji H, Kohara M, Kannagi M, Masuda T: Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integration. J Virol (2006) 80(15):7658-7666. • Targeting of the integrase gene in combination with the U3 region of the attachment site suppressed HIV-1 replication more effectively than Tat-specific shRNA, suggesting that HIV-1 integration may be an effective therapeutic target.
  • 93
    • 33748978456 scopus 로고    scopus 로고
    • The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference
    • Westerhout EM, ter Brake O, Berkhout B: The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interference. Retrovirology (2006) 3:57.
    • (2006) Retrovirology , vol.3 , pp. 57
    • Westerhout, E.M.1    ter Brake, O.2    Berkhout, B.3
  • 94
    • 33748850724 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA
    • Konstantinova P, de Vries W, Haasnoot J, ter Brake O, de Haan P, Berkhout B: Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA. Gene Ther (2006) 13(19):1403-1413.
    • (2006) Gene Ther , vol.13 , Issue.19 , pp. 1403-1413
    • Konstantinova, P.1    de Vries, W.2    Haasnoot, J.3    ter Brake, O.4    de Haan, P.5    Berkhout, B.6
  • 96
    • 34548129595 scopus 로고    scopus 로고
    • The response of mammalian cells to double-stranded RNA
    • Gantier MP, Williams BR: The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev (2007) 18(5-6):363-371.
    • (2007) Cytokine Growth Factor Rev , vol.18 , Issue.5-6 , pp. 363-371
    • Gantier, M.P.1    Williams, B.R.2
  • 97
    • 38449115829 scopus 로고    scopus 로고
    • Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids
    • Schlee M, Barchet W, Hornung V, Hartmann G: Beyond double-stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids. Curr Top Microbiol Immunol (2007) 316:207-230.
    • (2007) Curr Top Microbiol Immunol , vol.316 , pp. 207-230
    • Schlee, M.1    Barchet, W.2    Hornung, V.3    Hartmann, G.4
  • 98
    • 34548246501 scopus 로고    scopus 로고
    • Viral stress-inducible genes
    • Sen GC, Peters GA: Viral stress-inducible genes. Adv Virus Res (2007) 70:233-263.
    • (2007) Adv Virus Res , vol.70 , pp. 233-263
    • Sen, G.C.1    Peters, G.A.2
  • 103
    • 33947385291 scopus 로고    scopus 로고
    • Triboulet R, Mari B, Lin YL, Chable-Bessia C, Bennasser Y, Lebrigand K, Cardinaud B, Maurin T, Barbry P, Baillat V, Reynes J et al: Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science (2007) 315(5818):1579-1582. •• Dicer and Drosha, which are responsible for miRNA processing, inhibited HIV-1 replication. In turn, HIV-1 actively suppressed the expression of the polycistronic miRNA cluster miR-17/92. This suppression was required for efficient viral replication and was dependent on the Tat co-factor PCAF.
    • Triboulet R, Mari B, Lin YL, Chable-Bessia C, Bennasser Y, Lebrigand K, Cardinaud B, Maurin T, Barbry P, Baillat V, Reynes J et al: Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science (2007) 315(5818):1579-1582. •• Dicer and Drosha, which are responsible for miRNA processing, inhibited HIV-1 replication. In turn, HIV-1 actively suppressed the expression of the polycistronic miRNA cluster miR-17/92. This suppression was required for efficient viral replication and was dependent on the Tat co-factor PCAF.
  • 104
    • 34948817683 scopus 로고    scopus 로고
    • Huang J, Wang F, Argyris E, Chen K, Liang Z, Tian H, Huang W, Squires K, Verlinghieri G, Zhang H: Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med (2007) 13(10):1241-1247. •• HIV-1 mRNAs, which were enriched in resting CD4+ T-cells compared with activated CD4+ T-cells, were targeted by a cluster of cellular miRNAs (miR-28, -125b, -150, -223 and -382). These miRNAs appear to be involved in HIV-1 latency, and thus, manipulation of cellular miRNAs could be a novel strategy for purging the HIV-1 reservoir.
    • Huang J, Wang F, Argyris E, Chen K, Liang Z, Tian H, Huang W, Squires K, Verlinghieri G, Zhang H: Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med (2007) 13(10):1241-1247. •• HIV-1 mRNAs, which were enriched in resting CD4+ T-cells compared with activated CD4+ T-cells, were targeted by a cluster of cellular miRNAs (miR-28, -125b, -150, -223 and -382). These miRNAs appear to be involved in HIV-1 latency, and thus, manipulation of cellular miRNAs could be a novel strategy for purging the HIV-1 reservoir.
  • 107
    • 33645851037 scopus 로고    scopus 로고
    • Ribozyme: A clinical tool
    • Khan AU: Ribozyme: A clinical tool. Clin Chim Acta (2006) 367(1-2):20-27.
    • (2006) Clin Chim Acta , vol.367 , Issue.1-2 , pp. 20-27
    • Khan, A.U.1
  • 108
    • 12144291445 scopus 로고    scopus 로고
    • Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: Myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients
    • Amado RG, Mitsuyasu RT, Rosenblatt JD, Ngok FK, Bakker A, Cole S, Chorn N, Lin LS, Bristol G, Boyd MP, MacPherson JL et al: Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: Myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients. Hum Gene Ther (2004) 15(3):251-262.
    • (2004) Hum Gene Ther , vol.15 , Issue.3 , pp. 251-262
    • Amado, R.G.1    Mitsuyasu, R.T.2    Rosenblatt, J.D.3    Ngok, F.K.4    Bakker, A.5    Cole, S.6    Chorn, N.7    Lin, L.S.8    Bristol, G.9    Boyd, M.P.10    MacPherson, J.L.11
  • 110
    • 33748761365 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vectortransduced ribozyme in mammalian cells
    • Kaneko H, Suzuki H, Abe T, Miyano-Kurosaki N, Takaku H: Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vectortransduced ribozyme in mammalian cells. Biochem Biophys Res Commun (2006) 349(4):1220-1227.
    • (2006) Biochem Biophys Res Commun , vol.349 , Issue.4 , pp. 1220-1227
    • Kaneko, H.1    Suzuki, H.2    Abe, T.3    Miyano-Kurosaki, N.4    Takaku, H.5
  • 111
    • 33744482067 scopus 로고    scopus 로고
    • Assessment of an anti-HIV-1 combination gene therapy strategy using the antisense RNA and multimeric hammerhead ribozymes
    • Multimeric ribozymes specific to env and pol and an antisense targeting the packaging signal and gag substantially inhibited HIV-1 replication. A direct comparison suggested that ribozymes were more efficient at inhibiting HIV-1 replication than antisense, •
    • Ramezani A, Ma XZ, Ameli M, Arora A, Joshi S: Assessment of an anti-HIV-1 combination gene therapy strategy using the antisense RNA and multimeric hammerhead ribozymes. Front Biosci (2006) 11:2940-2948. • Multimeric ribozymes specific to env and pol and an antisense targeting the packaging signal and gag substantially inhibited HIV-1 replication. A direct comparison suggested that ribozymes were more efficient at inhibiting HIV-1 replication than antisense.
    • (2006) Front Biosci , vol.11 , pp. 2940-2948
    • Ramezani, A.1    Ma, X.Z.2    Ameli, M.3    Arora, A.4    Joshi, S.5
  • 112
    • 0033168686 scopus 로고    scopus 로고
    • A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34+ cells from the bone marrow of human immunodeficiency virus-1-infected children
    • Kohn DB, Bauer G, Rice CR, Rothschild JC, Carbonaro DA, Valdez P, Hao Q, Zhou C, Bahner I, Kearns K, Brody K et al: A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34+ cells from the bone marrow of human immunodeficiency virus-1-infected children. Blood (1999) 94(1):368-371.
    • (1999) Blood , vol.94 , Issue.1 , pp. 368-371
    • Kohn, D.B.1    Bauer, G.2    Rice, C.R.3    Rothschild, J.C.4    Carbonaro, D.A.5    Valdez, P.6    Hao, Q.7    Zhou, C.8    Bahner, I.9    Kearns, K.10    Brody, K.11
  • 113
    • 0028958967 scopus 로고
    • tRNAs as primer of reverse transcriptases
    • Marquet R, Isel C, Ehresmann C, Ehresmann B: tRNAs as primer of reverse transcriptases. Biochimie (1995) 77(1-2):113-124.
    • (1995) Biochimie , vol.77 , Issue.1-2 , pp. 113-124
    • Marquet, R.1    Isel, C.2    Ehresmann, C.3    Ehresmann, B.4
  • 114
    • 33644774584 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site
    • Eberhardy SR, Goncalves J, Coelho S, Segal DJ, Berkhout B, Barbas CF 3rd: Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol (2006) 80(6):2873-2883.
    • (2006) J Virol , vol.80 , Issue.6 , pp. 2873-2883
    • Eberhardy, S.R.1    Goncalves, J.2    Coelho, S.3    Segal, D.J.4    Berkhout, B.5    Barbas 3rd, C.F.6
  • 115
    • 35348952690 scopus 로고    scopus 로고
    • Antisense technology: A selective tool for gene expression regulation and gene targeting
    • Sahu NK, Shilakari G, Nayak A, Kohli DV: Antisense technology: A selective tool for gene expression regulation and gene targeting. Curr Pharm Biotechnol (2007) 8(5):291-304.
    • (2007) Curr Pharm Biotechnol , vol.8 , Issue.5 , pp. 291-304
    • Sahu, N.K.1    Shilakari, G.2    Nayak, A.3    Kohli, D.V.4
  • 116
    • 40849119735 scopus 로고    scopus 로고
    • Oligonucleotide antiviral therapeutics: Antisense and RNA interference for highly pathogenic RNA viruses
    • Spurgers KB, Sharkey CM, Warfield KL, Bavari S: Oligonucleotide antiviral therapeutics: Antisense and RNA interference for highly pathogenic RNA viruses. Antiviral Res (2008) 78(1):26-36.
    • (2008) Antiviral Res , vol.78 , Issue.1 , pp. 26-36
    • Spurgers, K.B.1    Sharkey, C.M.2    Warfield, K.L.3    Bavari, S.4
  • 117
    • 33751251058 scopus 로고    scopus 로고
    • Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD et al: Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci USA (2006) 103(46):17372-17377. • Infusion of autologous T-cells expressing a long env-specific antisense RNA was safe and correlated with beneficial effects in patients with advanced AIDS.
    • Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD et al: Gene transfer in humans using a conditionally replicating lentiviral vector. Proc Natl Acad Sci USA (2006) 103(46):17372-17377. • Infusion of autologous T-cells expressing a long env-specific antisense RNA was safe and correlated with beneficial effects in patients with advanced AIDS.
  • 119
    • 34248657564 scopus 로고    scopus 로고
    • Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites
    • Jakobsen MR, Haasnoot J, Wengel J, Berkhout B, Kjems J: Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites. Retrovirology (2007) 4:29.
    • (2007) Retrovirology , vol.4 , pp. 29
    • Jakobsen, M.R.1    Haasnoot, J.2    Wengel, J.3    Berkhout, B.4    Kjems, J.5
  • 120
    • 33748073127 scopus 로고    scopus 로고
    • Construction and use of retroviral vectors encoding the toxic gene barnase
    • Agarwal S, Nikolai B, Yamaguchi T, Lech P, Somia NV: Construction and use of retroviral vectors encoding the toxic gene barnase. Mol Ther (2006) 14(4):555-563.
    • (2006) Mol Ther , vol.14 , Issue.4 , pp. 555-563
    • Agarwal, S.1    Nikolai, B.2    Yamaguchi, T.3    Lech, P.4    Somia, N.V.5
  • 121
    • 33750721630 scopus 로고    scopus 로고
    • Stpc-based gene therapy targeting latent reservoirs of HIV-1
    • Turner LS, Tsugankov AY, Henderson EE: Stpc-based gene therapy targeting latent reservoirs of HIV-1. Antiviral Res (2006) 72(3):233-241.
    • (2006) Antiviral Res , vol.72 , Issue.3 , pp. 233-241
    • Turner, L.S.1    Tsugankov, A.Y.2    Henderson, E.E.3
  • 123
    • 0034254611 scopus 로고    scopus 로고
    • Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus-infected subjects
    • Mitsuyasu RT, Anton PA, Deeks SG, Scadden DT, Connick E, Downs MT, Bakker A, Roberts MR, June CH, Jalali S, Lin AA et al: Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus-infected subjects. Blood (2000) 96(3):785-793.
    • (2000) Blood , vol.96 , Issue.3 , pp. 785-793
    • Mitsuyasu, R.T.1    Anton, P.A.2    Deeks, S.G.3    Scadden, D.T.4    Connick, E.5    Downs, M.T.6    Bakker, A.7    Roberts, M.R.8    June, C.H.9    Jalali, S.10    Lin, A.A.11
  • 125
    • 34147222679 scopus 로고    scopus 로고
    • Telomerase induction in T cells: A cure for aging and disease?
    • Effros RB: Telomerase induction in T cells: A cure for aging and disease? Exp Gerontol (2007) 42(5):416-420.
    • (2007) Exp Gerontol , vol.42 , Issue.5 , pp. 416-420
    • Effros, R.B.1
  • 126
    • 0037372304 scopus 로고    scopus 로고
    • Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes
    • Dagarag M, Ng H, Lubong R, Effros RB, Yang OO: Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol (2003) 77(5):3077-3083.
    • (2003) J Virol , vol.77 , Issue.5 , pp. 3077-3083
    • Dagarag, M.1    Ng, H.2    Lubong, R.3    Effros, R.B.4    Yang, O.O.5
  • 127
    • 8444237735 scopus 로고    scopus 로고
    • Genetic manipulation of telomerase in HIV-specific CD8+ T cells: Enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization
    • Dagarag M, Evazyan T, Rao N, Effros RB: Genetic manipulation of telomerase in HIV-specific CD8+ T cells: Enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization. J Immunol (2004) 173(10):6303-6311.
    • (2004) J Immunol , vol.173 , Issue.10 , pp. 6303-6311
    • Dagarag, M.1    Evazyan, T.2    Rao, N.3    Effros, R.B.4
  • 128
    • 0032904280 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 by Tat/Rev-regulated expression of cytosine deaminase, interferon α2, or diphtheria toxin compared with inhibition by transdominant Rev
    • Ragheb JA, Couture L, Mullen C, Ridgway A, Morgan RA: Inhibition of human immunodeficiency virus type 1 by Tat/Rev-regulated expression of cytosine deaminase, interferon α2, or diphtheria toxin compared with inhibition by transdominant Rev. Hum Gene Ther (1999) 10(1):103-112.
    • (1999) Hum Gene Ther , vol.10 , Issue.1 , pp. 103-112
    • Ragheb, J.A.1    Couture, L.2    Mullen, C.3    Ridgway, A.4    Morgan, R.A.5
  • 130
    • 33746190700 scopus 로고    scopus 로고
    • α Interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells
    • Chen K, Huang J, Zhang C, Huang S, Nunnari G, Wang FX, Tong X, Gao L, Nikisher K, Zhang H: α Interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells. J Virol (2006) 80(15):7645-7657.
    • (2006) J Virol , vol.80 , Issue.15 , pp. 7645-7657
    • Chen, K.1    Huang, J.2    Zhang, C.3    Huang, S.4    Nunnari, G.5    Wang, F.X.6    Tong, X.7    Gao, L.8    Nikisher, K.9    Zhang, H.10
  • 132
    • 34147159787 scopus 로고    scopus 로고
    • Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors
    • Miyake K, Miyake N, Shimada T: Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors. J Biotechnol (2007) 129(3):532-538.
    • (2007) J Biotechnol , vol.129 , Issue.3 , pp. 532-538
    • Miyake, K.1    Miyake, N.2    Shimada, T.3
  • 133
    • 33846411813 scopus 로고    scopus 로고
    • Ex vivo expansion of hematopoietic stem cells and gene therapy development
    • Zubler RH: Ex vivo expansion of hematopoietic stem cells and gene therapy development. Swiss Med Wkly (2006) 136 (49-50):795-799.
    • (2006) Swiss Med Wkly , vol.136 , Issue.49-50 , pp. 795-799
    • Zubler, R.H.1
  • 134
    • 55049091782 scopus 로고    scopus 로고
    • Lentiviral vector gene transfer is limited by the proteasome at post-entry steps in various types of stem cells
    • Santoni de Sio FR, Gritti A, Cascio P, Neri M, Sampaolesi M, Galli C, Luban J, Naldini L: Lentiviral vector gene transfer is limited by the proteasome at post-entry steps in various types of stem cells. Stem Cells (2008) 26(8):2142-2152.
    • (2008) Stem Cells , vol.26 , Issue.8 , pp. 2142-2152
    • Santoni de Sio, F.R.1    Gritti, A.2    Cascio, P.3    Neri, M.4    Sampaolesi, M.5    Galli, C.6    Luban, J.7    Naldini, L.8
  • 135
    • 28444441312 scopus 로고    scopus 로고
    • Impact of gene-modified T cells on HIV infection dynamics
    • von Laer D, Hasselmann S, Hasselmann K: Impact of gene-modified T cells on HIV infection dynamics. J Theor Biol (2006) 238(1):60-77.
    • (2006) J Theor Biol , vol.238 , Issue.1 , pp. 60-77
    • von Laer, D.1    Hasselmann, S.2    Hasselmann, K.3
  • 136
    • 0141570489 scopus 로고    scopus 로고
    • Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection
    • Weinberger LS, Schaffer DV, Arkin AP: Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection. J Virol (2003) 77(18):10028-10036.
    • (2003) J Virol , vol.77 , Issue.18 , pp. 10028-10036
    • Weinberger, L.S.1    Schaffer, D.V.2    Arkin, A.P.3
  • 137
    • 33745384405 scopus 로고    scopus 로고
    • A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication
    • Westerhout EM, Vink M, Haasnoot PC, Das AT, Berkhout B: A conditionally replicating HIV-based vector that stably expresses an antiviral shRNA against HIV-1 replication. Mol Ther (2006) 14(2):268- 275.
    • (2006) Mol Ther , vol.14 , Issue.2 , pp. 268-275
    • Westerhout, E.M.1    Vink, M.2    Haasnoot, P.C.3    Das, A.T.4    Berkhout, B.5
  • 138
    • 0025914691 scopus 로고
    • Insertional mutagenesis: Neoplasia arising from retroviral integration
    • Gray DA: Insertional mutagenesis: Neoplasia arising from retroviral integration. Cancer Invest (1991) 9(3):295-304.
    • (1991) Cancer Invest , vol.9 , Issue.3 , pp. 295-304
    • Gray, D.A.1
  • 139
    • 0026131054 scopus 로고
    • Safety issues related to retroviral-mediated gene transfer in humans
    • Cornetta K, Morgan RA, Anderson WF: Safety issues related to retroviral-mediated gene transfer in humans. Hum Gene Ther (1991) 2(1):5-14.
    • (1991) Hum Gene Ther , vol.2 , Issue.1 , pp. 5-14
    • Cornetta, K.1    Morgan, R.A.2    Anderson, W.F.3
  • 142
    • 4444245489 scopus 로고    scopus 로고
    • Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors
    • Haviernik P, Bunting KD: Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors. Curr Gene Ther (2004) 4(3):263-276.
    • (2004) Curr Gene Ther , vol.4 , Issue.3 , pp. 263-276
    • Haviernik, P.1    Bunting, K.D.2
  • 143
    • 13844254514 scopus 로고    scopus 로고
    • Retroviral gene therapy: Safety issues and possible solutions
    • Yi Y, Hahm SH, Lee KH: Retroviral gene therapy: Safety issues and possible solutions. Curr Gene Ther (2005) 5(1):25-35.
    • (2005) Curr Gene Ther , vol.5 , Issue.1 , pp. 25-35
    • Yi, Y.1    Hahm, S.H.2    Lee, K.H.3
  • 150
    • 33744727387 scopus 로고    scopus 로고
    • Recent developments in delivery of nucleic acid-based antiviral agents
    • Christopher ME, Wong JP: Recent developments in delivery of nucleic acid-based antiviral agents. Curr Pharm Des (2006) 12(16):1995-2006.
    • (2006) Curr Pharm Des , vol.12 , Issue.16 , pp. 1995-2006
    • Christopher, M.E.1    Wong, J.P.2
  • 152
    • 44349165666 scopus 로고    scopus 로고
    • Cellular siRNA delivery mediated by a cell-permeant RNA-binding protein and photoinduced RNA interference
    • Endoh T, Sisido M, Ohtsuki T: Cellular siRNA delivery mediated by a cell-permeant RNA-binding protein and photoinduced RNA interference. Bioconjug Chem (2008) 19(5):1017-1024.
    • (2008) Bioconjug Chem , vol.19 , Issue.5 , pp. 1017-1024
    • Endoh, T.1    Sisido, M.2    Ohtsuki, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.