Analysis of BNP7787 thiol-disulfide exchange reactions in phosphate buffer and human plasma using microscale electrochemical high performance liquid chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 10, 2009, Pages 857-866

  Shanmugarajah, Dakshine ^a   Ding, Daoyuan ^a   Huang, Quili ^a   Chen, Xinghai ^a   Kochat, Harry ^a   Petluru, Pavankumar N ^a   Ayala, Philippe Y ^a   Parker, Aulma R ^a   Hausheer, Frederick H ^a  

^a BioNumerik Pharmaceuticals Inc   (United States)

Author keywords

BNP7787; Electrochemical detection; HPLC EC; Human plasma; Mesna; Mesna cysteine; Mesna cysteinyl glutamate; Mesna cysteinyl glycine; Mesna glutathione; Mesna homocysteine; Thiol disulfide exchange reactions

Indexed keywords

AGENTS; BLOOD VESSEL PROSTHESES; CHEMICAL MODIFICATION; CHROMATOGRAPHIC ANALYSIS; ELECTRIC CONDUCTIVITY MEASUREMENT; ETHANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; PLASMA (HUMAN); PLASMAS; PLATINUM COMPOUNDS; SULFUR COMPOUNDS;

BNP7787; ELECTROCHEMICAL DETECTION; HPLC-EC; HUMAN PLASMA; MESNA; MESNA-CYSTEINE; MESNA-CYSTEINYL-GLUTAMATE; MESNA-CYSTEINYL-GLYCINE; MESNA-GLUTATHIONE; MESNA-HOMOCYSTEINE; THIOL-DISULFIDE EXCHANGE REACTIONS;

CHEMICAL REACTIONS;

CISPLATIN; CYSTEINE; CYSTEINYLGLUTAMATE; CYSTEINYLGLYCINE; DIMESNA; GLUTATHIONE; HOMOCYSTEINE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; DRUG IDENTIFICATION; ELECTROCHEMICAL ANALYSIS; ELECTRODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NEPHROTOXICITY; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS;

BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISULFIDES; HUMANS; MESNA; PHOSPHATES; SENSITIVITY AND SPECIFICITY; SULFHYDRYL COMPOUNDS;

EID: 62249126184     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.02.056     Document Type: Article

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