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1
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55949130519
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IRIS 6-year follow-up: Sustained survival and declining annual rate of transformation in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib [abstract #25]
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Hochhaus A, Drucker BJ, Larson RA, et al. IRIS 6-year follow-up: sustained survival and declining annual rate of transformation in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib [abstract #25]. Blood 2007; 110.
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(2007)
Blood
, pp. 110
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Hochhaus, A.1
Drucker, B.J.2
Larson, R.A.3
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2
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33750057418
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High-dose imatinib mesylate treatment in patients (pts) with untreated early chronic phase (CP) chronic myeloid leukemia [abstract #6365]
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Aoki E, Kantarjian H, O'Brien S, et al. High-dose imatinib mesylate treatment in patients (pts) with untreated early chronic phase (CP) chronic myeloid leukemia [abstract #6365]. J Clin Oncol 2006; 20.
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(2006)
J Clin Oncol
, pp. 20
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Aoki, E.1
Kantarjian, H.2
O'Brien, S.3
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3
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62249130955
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First report of the TOPS study: A randomized phase III trial of 400 mg vs. 800 mg imatinib in patients with newly diagnosed, previously untreated CML in chronic phase using molecular endpoints [abstract #402]
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Cortes JE, Baccarani M, Guilhot F, et al. First report of the TOPS study: a randomized phase III trial of 400 mg vs. 800 mg imatinib in patients with newly diagnosed, previously untreated CML in chronic phase using molecular endpoints [abstract #402]. Haematologica 2008; 93.
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(2008)
Haematologica
, pp. 93
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Cortes, J.E.1
Baccarani, M.2
Guilhot, F.3
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4
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58149160055
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Impact of early dose intensity on cytogenetic and molecular responses in chronic-phase CML patients receiving 600mg/day of imatinib as initial therapy
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This study reports on the outcome of initial dose escalation of imatinib and aggressive dose optimization in chronic phase CML patients
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Hughes TP, Branford S, White DL, et al. Impact of early dose intensity on cytogenetic and molecular responses in chronic-phase CML patients receiving 600mg/day of imatinib as initial therapy. Blood 2008; 112:3965-3973. This study reports on the outcome of initial dose escalation of imatinib and aggressive dose optimization in chronic phase CML patients.
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(2008)
Blood
, vol.112
, pp. 3965-3973
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Hughes, T.P.1
Branford, S.2
White, D.L.3
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5
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47149088793
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Efficacy of nilotinib (AMN107) in patients (Pts) with newly diagnosed, previously untreated Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia in early chronic phase (CML-CP) [abstract #29]
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Cortes J, O'Brien S, Jabbour E, et al. Efficacy of nilotinib (AMN107) in patients (Pts) with newly diagnosed, previously untreated Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia in early chronic phase (CML-CP) [abstract #29], Blood 2007; 110.
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(2007)
Blood
, pp. 110
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Cortes, J.1
O'Brien, S.2
Jabbour, E.3
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6
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62249123303
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Efficacy of dasatinib in patients (pts) with previously untreated chronic myelogenous leukemia (CML) in early chronic phase (CML-CP) [abstract #30]
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Cortes J, O'Brien S, Jones D, et al. Efficacy of dasatinib in patients (pts) with previously untreated chronic myelogenous leukemia (CML) in early chronic phase (CML-CP) [abstract #30]. Blood 2007; 110.
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(2007)
Blood
, pp. 110
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Cortes, J.1
O'Brien, S.2
Jones, D.3
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8
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85117737937
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Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European Leukemia Net. Blood 2006; 108:1809-1820.
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Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European Leukemia Net. Blood 2006; 108:1809-1820.
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9
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58149396984
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European Leukemia Net criteria for failure or sub-optimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
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This study analyzes the outcome of patients with CML on imatinib characterized as suboptimal and failure by Leukemia Net guidelines and illustrates that outcomes may be similar
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Marin D, Milojkovic D, Olavarria E, et al. European Leukemia Net criteria for failure or sub-optimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood 2008; 112:4437-4444. This study analyzes the outcome of patients with CML on imatinib characterized as suboptimal and failure by Leukemia Net guidelines and illustrates that outcomes may be similar.
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(2008)
Blood
, vol.112
, pp. 4437-4444
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Marin, D.1
Milojkovic, D.2
Olavarria, E.3
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10
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85117739324
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Kantarjian H, Pasquini R, Hamerschlak N, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase-II trial. Blood 2007; 109:5143-5150. This paper reports on the only study randomizing imatinib failure patients to either higher dose imatinib or salvage with an alternative kinase inhibitor (here, dasatinib).
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Kantarjian H, Pasquini R, Hamerschlak N, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase-II trial. Blood 2007; 109:5143-5150. This paper reports on the only study randomizing imatinib failure patients to either higher dose imatinib or salvage with an alternative kinase inhibitor (here, dasatinib).
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11
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43549116467
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Importance of early intervention with dasatinib at cytogenetic rather than hematologic resistance to imatinib [abstract #1036]
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Kantarjian HM, Quintas-Cardama A, O'Brien S, et al. Importance of early intervention with dasatinib at cytogenetic rather than hematologic resistance to imatinib [abstract #1036]. Blood 2007; 110.
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(2007)
Blood
, pp. 110
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Kantarjian, H.M.1
Quintas-Cardama, A.2
O'Brien, S.3
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12
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54949154484
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Dasatinib 2-year efficacy in patients with chronic-phase chronic myetogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C) [abstract #7009]
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Mauro MJ, Baccarani M, Cervantes F, et al. Dasatinib 2-year efficacy in patients with chronic-phase chronic myetogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C) [abstract #7009]. J Clin Oncol 2008; 26.
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(2008)
J Clin Oncol
, pp. 26
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Mauro, M.J.1
Baccarani, M.2
Cervantes, F.3
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13
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36348968931
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Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
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This study reports on the efficacy of nilotinib in the treatment of imatinib-resistant or intolerant chronic phase CML
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Kantarjian HM, Giles F, Gattermann N, et al. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood 2007; 110:3540-3546. This study reports on the efficacy of nilotinib in the treatment of imatinib-resistant or intolerant chronic phase CML.
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(2007)
Blood
, vol.110
, pp. 3540-3546
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Kantarjian, H.M.1
Giles, F.2
Gattermann, N.3
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14
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43449091001
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Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis
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This study describes potential predisposing factors for the development of pleural effusions during dasatinib treatment
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De Lavallade H, Punnialingam S, Milojkovic D, et al. Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis. Br J Haematol 2008; 141:745-747. This study describes potential predisposing factors for the development of pleural effusions during dasatinib treatment.
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(2008)
Br J Haematol
, vol.141
, pp. 745-747
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De Lavallade, H.1
Punnialingam, S.2
Milojkovic, D.3
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15
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24744443720
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High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: Correlation with clonal cytogenetic evolution but not response to therapy
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Willis SG, Lange T, Demehri S, et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005; 106:2128-2137.
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(2005)
Blood
, vol.106
, pp. 2128-2137
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Willis, S.G.1
Lange, T.2
Demehri, S.3
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16
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49249121723
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Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia
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This study reports on a 'dose optimization' study of dasatinib in chronic phase CML patients and the rationale behind reduction in the recommended dose to 100 mg daily
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Shah NP, Kantarjian HM, Kim D-W, et al. Intermittent target inhibition with dasatinib 100 mg once daily preserves efficacy and improves tolerability in imatinib-resistant and -intolerant chronic-phase chronic myeloid leukemia. J Clin Oncol 2008; 26:3204-3212. This study reports on a 'dose optimization' study of dasatinib in chronic phase CML patients and the rationale behind reduction in the recommended dose to 100 mg daily.
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(2008)
J Clin Oncol
, vol.26
, pp. 3204-3212
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Shah, N.P.1
Kantarjian, H.M.2
Kim, D.-W.3
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