Preoperative short-course radiotherapy versus combined radiochemotherapy in locally advanced rectal cancer: A multi-centre prospectively randomised study of the Berlin Cancer Society

BMC Cancer

Volumn 9, Issue , 2009, Pages

  Siegel, Robert ^a   Burock, Susen ^a   Wernecke, Klaus Dieter ^a   Kretzschmar, Albrecht ^b   Dietel, Manfred ^a   Loy, Volker ^c   Koswig, Stephan ^d   Budach, Volker ^d   Schlag, Peter M ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HELIOS Kliniken GmbH   (Germany)

^c VIVANTES HOSPITAL   (Germany)

^d Helios Kliniken   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL;

ADULT; ADVANCED CANCER; ANUS SPHINCTER; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FOLLOW UP; GERMANY; HISTOPATHOLOGY; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MORBIDITY; MULTICENTER STUDY; OVERALL SURVIVAL; PREOPERATIVE RADIOCHEMOTHERAPY; PREOPERATIVE RADIOTHERAPY; QUALITY OF LIFE; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RANDOMIZED CONTROLLED TRIAL; RECTUM CANCER; RECTUM RESECTION; SHORT COURSE THERAPY; ADJUVANT THERAPY; COMPARATIVE STUDY; FEMALE; MALE; MIDDLE AGED; MORTALITY; PATIENT SELECTION; PREOPERATIVE CARE; PROSPECTIVE STUDY; RECTUM TUMOR; SURVIVAL;

ADULT; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; GERMANY; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; PATIENT SELECTION; PREOPERATIVE CARE; PROSPECTIVE STUDIES; RECTAL NEOPLASMS; SURVIVAL; YOUNG ADULT;

EID: 62249096271     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-50     Document Type: Article

References (16)

1. Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V.(Hrsg) Krebs in Deutschland 2003 - 2004 Häufigkeiten und Trends. 6. überarbeitete Auflage 2008.
2. NIH Consensus conference. Adjuvant therapy for patients with colon and rectal cancer JAMA 1990, 264:1444-1450. 10.1001/jama.264.11.1444 2202842
3. Camma C Giunta M Fiorica F Pagliaro L Craxi A Cottone M Preoperative radiotherapy for resectable rectal cancer: A meta-analysis JAMA 2000, 284:1008-1015. 10.1001/jama.284.8.1008 10944647
4. Kapiteijn E Marijnen CA Nagtegaal ID Putter H Steup WH Wiggers T Rutten HJ Pahlman L Glimelius B van Krieken JH Leer JW Velde van de CJ Dutch Colorectal Cancer Group Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer N Engl J Med 2001, 345:638-646. 10.1056/NEJMoa010580 11547717
5. Swedish Rectal CT Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer N Engl J Med 1997, 336:980-987. 10.1056/ NEJM199704033361402 9091798
6. Sauer R Becker H Hohenberger W Rödel C Wittekind C Fietkau R Martus P Tschmelitsch J Hager E Hess CF Karstens JH Liersch T Schmidberger H Raab R German Rectal Cancer Study Group Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer N Engl J Med 2004, 351:1731-1740. 10.1056/NEJMoa040694 15496622
7. Heald RJ Moran BJ Ryall RD Sexton R MacFarlane JK Rectal cancer: The Basingstoke experience of total mesorectal excision, 1978-1997 Arch Surg 1998, 133:894-899. 10.1001/archsurg.133.8.894 9711965
8. Bosset JF Collette L Calais G Mineur L Maingon P Radosevic-Jelic L Daban A Bardet E Beny A Ollier JC EORTC Radiotherapy Group Trial 22921 Chemotherapy with Preoperative Radiotherapy in Rectal Cancer N Engl J Med 2006, 355:1114-1123. 10.1056/NEJMoa060829 16971718
9. Bujko K Nowacki MP Nasierowska-Guttmejer A Michalski W Bebenek M Kryj M Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer Br J Surg 2006, 93:1215-23. 10.1002/ bjs.5506 16983741
10. Kachnic LA Hong TS Ryan DP Rectal cancer at the crossroads: The dilemma of clinically staged T3, N0, M0 disease J Clin Oncol 2008, 26:350-351. 10.1200/JCO.2007.14.6365 18202407
11. Kauermann G Penelized spline smoothing in multiple variable models with varying coefficients Computational Statistics and Data Analysis 2005, 49:169-186. 10.1016/j.csda.2004.05.006
12. O'Brien PC Fleming TR A multiple testing procedure for clinical trials Biometrics 1979, 35:549-556. 10.2307/2530245 497341
13. Taves DR Minimization: A new method of assigning patients to treatment and control groups Clin Pharmacol Ther 1974, 15:443-453. 4597226
14. Widder J Sedlmayer F Stanek C Potter R Quality assurance in preoperative radiotherapy of rectal cancer: Evaluation of a pre-trial dummy-run Radiother Oncol 2000, 56:341-347. 10.1016/S0167-8140(00)00232-2 10974384
15. Quirke P The pathologist, the surgeon and colorectal cancer get it right because it matters Prog Pathol 1998, 4:201-213.
16. Dworak O Keilholz L Hoffmann A Pathological features of rectal cancer after preoperative radiochemotherapy Int J Colorectal Dis 1997, 12:19-23. 10.1007/s003840050072 9112145