Setting up a 2D-LC/MS/MS method for the rapid quantitation of the prostanoid metabolites 6-oxo-PGF1α and TXB2 as markers for hemostasis assessment

Journal of Mass Spectrometry

Volumn 44, Issue 3, 2009, Pages 346-352

  Casetta, Bruno ^a   Vecchione, Gennaro ^b   Tomaiuolo, Michela ^b   Margaglione, Maurizio ^b   Grandone, Elvira ^b  

^a Applied Biosystems   (Italy)

^b Casa di Cura Sollievo della Sofferenza   (Italy)

Author keywords

Electrospray ionization; Hemostasis; On line SPE; Prostaglandin; Prostanoids; Tandem mass spectrometry; Thromboxane

Indexed keywords

HEMOSTASIS; ON-LINE SPE; PROSTAGLANDIN; PROSTANOIDS; TANDEM MASS SPECTROMETRY; THROMBOXANE;

ACIDS; BIOCHEMISTRY; BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; IONIZATION; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PLASMAS; PRECIPITATION (CHEMICAL); SOLAR RADIATION; SPECTRUM ANALYSIS; TWO DIMENSIONAL;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

6 OXOPROSTAGLANDIN F1 ALPHA; BIOLOGICAL MARKER; THROMBOXANE B2;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; HEMOSTASIS; LIQUID CHROMATOGRAPHY; PLASMA; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUPERNATANT; TANDEM MASS SPECTROMETRY;

6-KETOPROSTAGLANDIN F1 ALPHA; CHROMATOGRAPHY, LIQUID; EQUIPMENT DESIGN; HUMANS; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; THROMBOXANES;

EID: 62149139731     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1511     Document Type: Article

References (27)

1. W. L. Smith, R. Langenbach. Why there are two cyclooxygenase isozymes. Journal of Clinical Investigation 2001, 107, 1491.
2. L. Pang, A. Pitt, D. Petkova, A. J. Knox. The COX-1/COX-2 balance in asthma. Clinical and Experimental Allergy 1998, 28, 1050.
3. T. Hishinuma, Y. Koseki, Y.Murai, J. Kotake, F.Ishii, K. Suzuki, M. Mizugaki. Elevation of the thromboxane A2/prostacyclin ratio in urine of diabetic mice analyzed by gas chromatography/selected ion monitoring. Prostaglandins & Other Lipid Mediators 1998, 55, 83.
4. S. S. Bhagwat, P. R. Hamann, W. C. Still, S. Bunting, F. A. Fitzpatrick. Synthesis and structure of the platelet aggregation factor thromboxane A2. Nature 1985, 315, 511.
5. M. Hamberg, J. Svensson, B. Samuelsson. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proceedings of the National Academy of Sciences of the United States of America 1975, 72, 2994.
6. J. Svenssen, K. Strandberg, T. Tuvemo, M. Hamberg. Thromboxane A2: effects on airway and vascular smooth muscle. Prostaglandins 1977, 14, 425.
7. J. A. Oates, G. A. FitzGerald, R. A. Branch, E. K. Jackson, H. R. Knapp, L. J. Roberts 2nd. Clinical implications of prostaglandin and thromboxane A2 formation (1). New England Journal of Medicine 1988, 319, 689.
8. T. Hishinuma, H. Tsukamoto, K. Suzuki, M. Mizugaki. Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. Prostaglandins Leukotrienes and Essential Fatty Acids 2001, 65, 191.
9. M. Cocozza, T. Picano, U. Oliviero, N. Russo, V. Coto, M. Milani. Effects of picotamide, an antithromboxane agent, on carotid atherosclerotic evolution. A two-year, double-blind, placebo-controlled study in diabetic patients. Stroke 1995, 26, 597.
10. T. Hishinuma, H. Nakamura, T. Sawai, M. Uzuki, Y. Itabash, M. Mizugaki. Microdetermination of prostaglandin E2 in joint fluid in rheumatoid arthritis patients using gas chromatography/selected ion monitoring. Prostaglandins & Other Lipid Mediators 1999, 58, 179.
11. B. Battistini, S. Picard, P. Borgeat, P. Sirois. Measurements of prostanoids, leukotrienes, and isoprostanes by enzyme immunoassays. Methods in Molecular Biology 1998, 105, 201.
12. B. Battistini, S. Picard, P. Borgeat, P. Sirois. Extraction and measurements of prostanoids and leukotrienes by radioimmunoassays. Methods in Molecular Biology 1998, 105, 187.
13. M. Kumlin, E. Granstrom. Radioimmunoassay for 11-dehydro-TXB2: a method for monitoring thromboxane production in vivo. Prostaglandins 1986, 32, 741.
14. C. Weber, J. R. Beetens, R. Van de Wiele, M. Holler, F. De Clerck. Production of thromboxane and prostaglandins in human blood in the presence of thromboxane synthase inhibitors: a comparison of RIA and GC/MS determinations. Blood Coagulation & Fibrinolysis 1991, 2, 7.
15. D. Tsikas. Application of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry to assess in vivo synthesis of prostaglandins, thromboxane, leukotrienes, isoprostanes and related compounds in humans. Journal of Chromatography B: Biomedical Sciences and Applications 1998, 717, 201.
16. C. Weber, M. Höller, J. Beetens, F. De Clerck, F. Tegtmeier. Determination of 6-oxo-PGF1 alpha, 2,3-dinor-6-oxo-PGF1 alpha, thromboxane B2, 2,3-dinor-thromboxane B2, PGE2, PGD2 and PGF2 alpha in human urine by gas chromatography-negative ion chemical ionization mass spectrometry. Journal of Chromatography 1991, 562, 599.
17. T. Obata, T. Nagakura, H. Maeda, K. Yamashita, K. Maekawa. Simultaneous assay of prostaglandins and thromboxane in the cerebrospinal fluid by gas chromatography-mass spectrometry-selected ion monitoring. Journal of Chromatography B: Biomedical Sciences and Applications 1999, 731, 73.
18. H. Tsukamoto, T. Hishinuma, T. Mikkaichi, H. Nakamura, T. Yamazaki, Y. Tomioka, M. Mizugaki. Simultaneous quantification of prostaglandins, isoprostane and thromboxane in cell-cultured medium using gas chromatography-mass spectrometry. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences 2002, 774, 205.
19. T. Hishinuma, K. Suzuki, M. Saito, H. Yamaguchi, N. Suzuki, Y. Tomioka, I. Kaneko, M. Ono, J. Goto. Simultaneous quantification of seven prostanoids using liquid chromatography/tandem mass spectrometry: the effects of arachidonic acid on prostanoid production in mouse bone marrow-derived mast cells. Prostaglandins Leukotrienes and Essential Fatty Acids 2007, 76, 321.
20. P. J. Kingsley, C. A. Rouzer, S. Saleh, L. J. Marnett. Simultaneous analysis of prostaglandin glyceryl esters and prostaglandins by electrospray tandem mass spectrometry. Analytical Biochemistry 2005, 343, 203.
21. D. Sircar, P. V. Subbaiah. Isoprostane measurement in plasma and urine by liquid chromatography-mass spectrometrywith one-step sample preparation. Clinical Chemistry 2007, 53, 251.
22. M. E. Chavarría, L. Lara-González, A. González- Gleason, Y. García-Paleta, V. S. Vital-Reyes, A. Reyes. Prostacyclin/thromboxane early changes in pregnancies that are complicated by preeclampsia. American Journal of Obstetrics and Gynecology 2003, 188, 986.
23. T. Koal, M. Deters, B. Casetta, V. Kaever. Simultaneous determination of four immunosuppressants by means of high speed and robust on-line solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences 2004, 805, 215.
24. U. Ceglarek, B. Casetta, J. Lembcke, S. Baumann, G. M. Fiedler, J. Thiery. Inclusion of MPA and in a rapid multi-drug LC-tandem mass spectrometric method for simultaneous determination of immunosuppressants. Clinica Chimica Acta 2006, 373, 168.
25. G. Corona, B. Casetta, S. Sandron, E. Vaccher, G. Toffoli. Rapid and sensitive analysis of vincristine in human plasma using on-line extraction combined with liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2008, 22, 519.
26. G. Vecchione, B. Casetta, M. Tomaiuolo, E. Grandone, M. Margaglione. A rapid method for the quantification of the enantiomers of Warfarin, Phenprocoumon and Acenocoumarol by two-dimensional-enantioselective liquid chromatography/electrospray tandem mass spectrometry. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences 2007, 850, 507.
27. H. John, W. Schlegel. Reversed-phase high-performance liquid chromatographic method for the determination of the 11-hydroxythromboxane B2 anomers equilibrium. Journal of Chromatography B: Biomedical Sciences and Applications 1997, 698, 9.