Mom and me: Brain metabolism links Alzheimer disease to maternal genes

Neurology

Volumn 72, Issue 6, 2009, Pages 486-487

  Eidelberg, David ^a   Dhawan, Vijay ^b  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; FLUORODEOXYGLUCOSE F 18; MITOCHONDRIAL DNA; TAU PROTEIN; GLUCOSE;

ALZHEIMER DISEASE; BRAIN METABOLISM; EDITORIAL; FAMILY HISTORY; HUMAN; MITOCHONDRIAL GENE; NEUROFIBRILLARY TANGLE; OXIDATIVE STRESS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; BRAIN; FEMALE; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; MALE; METABOLISM; MOTHER; NOTE;

ALZHEIMER DISEASE; BRAIN; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; HETEROZYGOTE; HUMANS; MALE; MOTHERS;

EID: 62149127013     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/01.wnl.0000341939.31303.32     Document Type: Editorial

References (11)

1. Mosconi L, Mistur R, Switalski R, et al. Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease. Neurology 2009;72:513-520.
2. Lin MT, Beal MF. Mitochondrial dysfunction and oxida-tive stress in neurodegenerative diseases. Nature 2006;443: 787-795.
3. Jagust W, Reed B, Mungas D, Ellis W, Decarli C. What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia? Neurology 2007;69:871-877.
4. Silverman DH, Mosconi L, Ercoli L, Chen W, Small GW. Positron emission tomography scans obtained for the evaluation of cognitive dysfunction. Semin Nucl Med 2008; 38:251-261.
5. Asllani I, Habeck C, Scarmeas N, Borogovac A, Brown TR, Stern Y. Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's disease. J Cereb Blood Flow Metab 2008;28:725-736.
6. Huang C, Eidelberg D, Habeck C, et al. Imaging markers of mild cognitive impairment: multivariate analysis of CBF SPECT. Neurobiol Aging 2007;28:1062-1069.
7. Anandatheerthavarada HK, Biswas G, Robin MA, Avadhani NG. Mitochondrial targeting and a novel trans-membrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J Cell Biol 2003;161:41-54.
8. Khan SM, Cassarino DS, Abramova NN, et al. Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways. Ann Neurol 2000;48:148-155.
9. Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Postmortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008;131:1630-1645.
10. Barrio JR, Kepe V, Satyamurthy N, Huang SC, Small G. Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment. J Nutr Health Aging 2008; 12:61S-65S.
11. Valeo T. New therapies in the pipeline for AD: what's promising, what's not. Neurology Today 2008;8:13-14.