Epigenetic modification of the gene for the vitamin B12 chaperone MMACHC can result in increased tumorigenicity and methionine dependence

Molecular Genetics and Metabolism

Volumn 96, Issue 4, 2009, Pages 261-267

  Loewy, Amanda D ^a   Niles, Kirsten M ^b   Anastasio, Natascia ^a   Watkins, David ^a   Lavoie, Josée ^c   Lerner Ellis, Jordan P ^a   Pastinen, Tomi ^c   Trasler, Jacquetta M ^b   Rosenblatt, David S ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Cancer; Cobalamin; Melanoma; Methionine; Methionine dependence; Tumorigenicity; Vitamin B12

Indexed keywords

CHAPERONE; CYANOCOBALAMIN; HOMOCYSTEINE; METHIONINE; METHIONINE SYNTHASE; METHYLMALONYL COENZYME A MUTASE; PROTEIN MMACHC; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ACTB GENE; ARTICLE; CANCER CELL CULTURE; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; CPG ISLAND; DNA MODIFICATION; ENZYME ACTIVITY; EPIGENETICS; GAPDH GENE; GENE; GENE INACTIVATION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; INBORN ERROR OF METABOLISM; MELANOMA CELL; METHYLATION; MMAA GENE; MMAB GENE; MMACHC GENE; MTR GENE; MTRR GENE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; WILD TYPE;

ALLELES; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CPG ISLANDS; DNA METHYLATION; DNA, COMPLEMENTARY; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; METHIONINE; MOLECULAR CHAPERONES; NEOPLASM PROTEINS; NEOPLASMS; TRANSFECTION; VITAMIN B 12;

EID: 62149121345     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2008.12.011     Document Type: Article

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