Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice

Journal of Cellular Physiology

Volumn 219, Issue 2, 2009, Pages 430-437

  Luong, Mai X ^a,e   Tam, Joshua ^a,b   Lin, Qingcong ^c   Hagendoorn, Jeroen ^a,f   Moore, Kathryn J ^a   Padera, Timothy P ^a   Seed, Brian ^a   Fukumura, Dai ^a   Kucherlapati, Raju ^d   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c PFIZER INC   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; HERMES ANTIGEN; LYMPHATIC VESSEL ENDOTHELIAL HYALURONAN RECEPTOR 1; RECEPTOR; UNCLASSIFIED DRUG; CD44 PROTEIN, MOUSE; GLYCOPROTEIN; XLKD1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENOTYPE; HISTOPATHOLOGY; INFLAMMATION; KNOCKOUT MOUSE; LYMPH VESSEL; MACROMOLECULE; MALE; MICROSCOPY; MORPHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PAW EDEMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; EMBRYONIC STEM CELL; GENETICS; HISTOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

MUS;

ANIMALS; ANTIGENS, CD44; EMBRYONIC STEM CELLS; FEMALE; GENOTYPE; GLYCOPROTEINS; LYMPHATIC VESSELS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE;

EID: 62149116036     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21686     Document Type: Article

References (39)

1. Achen MG, McColl BK, Stacker SA. 2005. Focus on lymphangiogenesis in tumor metastasis. Cancer Cell 7:121-127.
2. Alitalo K, Carmeliet P. 2002. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1:219-227.
3. Banerji S, Ni J, Wang SX, Clasper S, Su J, Tammi R, Jones M, Jackson DG. 1999. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 144:789-801.
4. DeGrendele HC, Estess P, Siegelman MH. 1997. Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science 278:672-675.
5. di Meglio P, Ianaro A, Ghosh S. 2005. Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum 52:951-958.
6. Fernandes D, Assreuy J. 2004. Involvement of guanylate cyclase and potassium channels on the delayed phase of mouse carrageenan-induced paw oedema. Eur J Pharmacol 501:209-214.
7. Gale NW, Prevo R, Espinosa J, Ferguson DJ, Dominguez MG, Yancopoulos GD, Thurston G, Jackson DG. 2007. Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1. Mol Cell Biol 27:595-604.
8. Gee K, Kryworuchko M, Kumar A. 2004. Recent advances in the regulation of CD44 expression and its role in inflammation and autoimmune diseases. Arch Immunol Ther Exp (Warsz) 52:13-26.
9. Gordon EJ, Gale NW, Harvey NL. 2008. Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Dev Dyn 237:1901-1909.
10. Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK. 2004. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res 95:204-209.
11. Jackson DG. 2004. Biology of the lymphatic marker LYVE-1 and applications in research into lymphatic trafficking and lymphangiogenesis. APMIS 112:526-538.
12. Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K. 1997. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 276:1423-1425.
13. Karkkainen MJ,Haiko P, Sainio K, Partanen J, Taipale J, Petrova TV, Jeltsch M, Jackson DG, Talikka M, Rauvala H, Betsholtz C, Alitalo K. 2004. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 5:74-80.
14. Knudson CB, Knudson W. 1993. Hyaluronan-binding proteins in development, tissue homeostasis, and disease. FASEB J 7:1233-1241.
15. Kubo H, Fujiwara T, Jussila L, Hashi H, Ogawa M, Shimizu K, Awane M, Sakai Y, Takabayashi A, Alitalo K, Yamaoka Y, Nishikawa SI. 2000. Involvement of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis. Blood 96:546-553.
16. Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, Jenkins NA, Copeland NG. 2001. A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73:56-65.
17. Makinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA. 2005. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev 19:397-410.
18. McKee CM, Penno MB, Cowman M, Burdick MD, Strieter RM, Bao C, Noble PW. 1996. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest 98:2403-2413.
19. Mohamadzadeh M, DeGrendele H, Arizpe H, Estess P, Siegelman M. 1998. Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion. J Clin Invest 101:97-108.
20. Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW. 2000. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol 165:4272-4280.
21. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK. 2001. LYVE-1 is not restricted to the lymph vessels: Expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res 61:8079-8084.
22. Nandi A, Estess P, Siegelman MH. 2000. Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44. J Biol Chem 275:14939-14948.
23. Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. 2007. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia 9:1038-1045.
24. Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G. 2004. Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Br J Pharmacol 142:331-338.
25. Potter PK, Cortes-Hernandez J, Quartier P, Botto M, Walport MJ. 2003. Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells. J Immunol 170:3223-3232.
26. Prevo R, Banerji S, Ferguson DJ, Clasper S, Jackson DG. 2001. Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium. J Biol Chem 276:19420-19430.
27. Protin U, Schweighoffer T, Jochum W, Hilberg F. 1999. CD44-deficient mice develop normally with changes in subpopulations and recirculation of lymphocyte subsets. J Immunol 163:4917-4923.
28. Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. 2004. Lymphatic vasculature: Development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 25:387-395.
29. Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M. 2003. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J 22:3546-3556.
30. Schmid-Schonbein GW. 1990. Microlymphatics and lymph flow. Physiol Rev 70:987-1028.
31. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, Kundig T, Wakeham A, Shahinian A, Catzavelos C, Rak J, Furlonger C, Zakarian A, Simard JJ, Ohashi PS, Paige CJ, Gutierrez-Ramos JC, Mak TW. 1997. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90:2217-2233.
32. Swartz MA, Berk DA, Jain RK. 1996. Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory. Am J Physiol 270:H324-H329.
33. Tammela T, Saaristo A, Holopainen T, Lyytikka J, Kotronen A, Pitkonen M, Abo-Ramadan U, Yla-Herttuala S, Petrova TV, Alitalo K. 2007. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation. Nat Med 13:1458-1466.
34. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, Henson PM, Noble PW. 2002. Resolution of lung inflammation by CD44. Science 296:155-158.
35. Termeer CC, Hennies J, Voith U, Ahrens T, Weiss JM, Prehm P, Simon JC. 2000. Oligosaccharides of hyaluronan are potent activators of dendritic cells. J Immunol 165:1863-1870.
36. Weber GF, Bronson RT, Ilagan J, Cantor H, Schmits R, Mak TW. 2002. Absence of the CD44 gene prevents sarcoma metastasis. Cancer Res 62:2281-2286.
37. West DC, Hampson IN, Arnold F, Kumar S. 1985. Angiogenesis induced by degradation products of hyaluronic acid. Science 228:1324-1326.
38. Wigle JT, Oliver G. 1999. Prox1 function is required for the development of the murine lymphatic system. Cell 98:769-778.
39. Wigle JT, Harvey N, Detmar M, Lagutina I, Grosveld G, Gunn MD, Jackson DG, Oliver G. 2002. An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J 21:1505-1513.