(-)-Dibromophakellin: An α2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2497-2500

  Davis, Rohan A ^a   Fechner, Gregory A ^a   Sykes, Melissa ^a   Garavelas, Agatha ^a   Pass, David M ^a   Carroll, Anthony R ^a   Addepalli, Rama ^a   Avery, Vicky M ^a   Hooper, John N A ^b   Quinn, Ronald J ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b QUEENSLAND MUSEUM   (Australia)

Author keywords

2B Adrenoceptor; ( ) Dibromophakellin; Acanthella costata; Analogs; Bioassay guided fractionation; Marine sponge

Indexed keywords

4 BROMO 5 PHENYLPHAKELLIN; 4,5 DIPHENYLPHAKELLIN; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR AGONIST; BROMINE; DIBROMOPHAKELLIN; MONOBROMOPHAKELLIN; PHAKELLIN; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; FUSED HETEROCYCLIC RINGS;

ACANTHELLA COSTATA; ARTICLE; DEBROMINATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUZUKI REACTION; ANIMAL; AUSTRALIA; CELL LINE; CHEMISTRY; ISOLATION AND PURIFICATION; ULTRAVIOLET SPECTROPHOTOMETRY;

ACANTHELLA;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; AUSTRALIA; CELL LINE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; PORIFERA; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 62149105957     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.065     Document Type: Article

References (20)

1. Gentili F., Pigini M., Piergentili A., and Giannella M. Curr. Top. Med. Chem. 7 (2007) 163
2. Fulop K., Zadori Z., Ronai A.Z., and Gyires K. Eur. J. Pharmacol. 528 (2005) 150
3. Docherty J.R. Eur. J. Pharmacol. 361 (1998) 1
4. Sanders R.D., and Maze M. Curr. Opin. Investig. Drugs 8 (2007) 25
5. Bekker A., and Jorden V.S.B. Semin. Anesth. Perioper. Med. Pain 23 (2004) 181
6. Sharma G., and Magdoff-Fairchild B. J. Org. Chem. 42 (1977) 4118
7. Anwer M.K., and Spatola A.F. Tetrahedron Lett. 26 (1985) 1381
8. Banwell M.G., Goodwin T.E., Ng S., Smith J.A., and Wong D.J. Eur. J. Org. Chem. (2006) 3043
9. Miyaura N., and Suzuki A. Chem. Rev. (Washington, DC) 95 (1995) 2457
10. Schröter S., and Bach T. Synlett (2005) 1957
11. Handy S.T., and Sabatini J.J. Org. Lett. 8 (2006) 1537
12. Banwell M.G., Hamel E., Hockless D.C.R., Verdier-Pinard P., Willis A.C., and Wong D.J. Bioorg. Med. Chem. 14 (2006) 4627
13. Ghosez L., Franc C., Denonne F., Cuisinier C., and Touillaux R. Can. J. Chem. 79 (2001) 1827
14. Wang D., and Haseltine J. J. Heterocycl. Chem. 31 (1994) 1637
15. Handy S.T., Bregman H., Lewis J., Zhang X., and Zhang Y. Tetrahedron Lett. 44 (2003) 427
16. Handy S.T., Zhang Y., and Bregman H. J. Org. Chem. 2004 (2003) 2362
17. Smith J.A., Ng S., and White J. Org. Biomol. Chem. 4 (2006) 2477
18. Kikuchi K., Hannak R.B., Guo M.-J., Kirby A.J., and Hilvert D. Bioorg. Med. Chem. 14 (2006) 6189
19. Kocienski P.J. Protective Groups. 1st ed. (1994), G. Thieme
20. Schröter S., Stock C., and Bach T. Tetrahedron 61 (2005) 2245