Dysregulation of cell death machinery in the prefrontal cortex of human alcoholics

International Journal of Neuropsychopharmacology

Volumn 12, Issue 1, 2009, Pages 109-115

  Johansson, Sofia ^a   Ekström, Tomas J ^a   Marinova, Zoya ^a   Ökvist, Anna ^a   Sheedy, Donna ^b   Garrick, Therese ^b   Harper, Clive ^b   Kuzmin, Alexander ^a,c   Yakovleva, Tatjana ^c   Bakalkin, Georgy ^c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Alcoholism; Apoptosis; Neurotoxicity; Post mortem brain; Prefrontal cortex

Indexed keywords

MESSENGER RNA; APOPTOSIS REGULATORY PROTEIN;

ADULT; AGED; ALCOHOL WITHDRAWAL; ALCOHOLISM; APOPTOSIS; ARTICLE; CELL DEATH; CELL DENSITY; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; MALE; MOLECULAR BIOLOGY; MOTOR CORTEX; NEUROTOXICITY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; BIOSYNTHESIS; DRUG EFFECT; GENETICS; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ALCOHOLISM; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL DEATH; HUMANS; MALE; MIDDLE AGED; MOTOR CORTEX; PREFRONTAL CORTEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 61949299281     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145708009589     Document Type: Article

References (21)

1. Chanraud S, Martelli C, Delain F, Kostogianni N, Douaud G, Aubin HJ, Reynaud M, Martinot JL (2007). Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning. Neuropsychopharmacology 32, 429-438.
2. Dao-Castellana MH, Samson Y, Legault F, Martinot JL, Aubin HJ, Crouzel C, Feldman L, Barrucand D, Rancurel G, Féline A, Syrota A (1998). Frontal dysfunction in neurologically normal chronic alcoholic subjects: metabolic and neuropsychological findings. Psychological Medicine 28, 1039-1048.
3. Fadda F, Rossetti ZL (1998). Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Progress in Neurobiology 56, 385-431.
4. Flatscher-Bader T, van der Brug M, Hwang JW, Gochee PA, Matsumoto I, Niwa S, Wilce PA (2005). Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. Journal of Neurochemistry 93, 359-370.
5. Freund G (1994). Apoptosis and gene expression: perspectives on alcohol-induced brain damage. Alcohol 11, 385-387.
6. Goldstein RZ, Leskovjan AC, Hoff AL, Hitzemann R, Bashan F, Khalsa SS, Wang GJ, Fowler JS, Volkow ND (2004). Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex. Neuropsychologia 42, 1447-1458.
7. Harper C, Dixon G, Sheedy D, Garrick T (2003). Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. Progress in Neuropsychopharmacology and Biological Psychiatry 27, 951-961.
8. Heaton MB, Moore DB, Paiva M, Gibbs T, Bernard O (1999). Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity. Brain Research 817, 13-18.
9. Ikegami Y, Goodenough S, Inoue Y, Dodd PR, Wilce PA, Matsumoto I (2003). Increased TUNEL positive cells in human alcoholic brains. Neuroscience Letters 349, 201-205.
10. Johansson S, Fuchs A, Okvist A, Karimi M, Harper C, Garrick T, Sheedy D, Hurd Y, Bakalkin G, Ekstrom TJ (2007). Validation of endogenous controls for quantitative gene expression analysis: application on brain cortices of human chronic alcoholics. Brain Research 1132, 20-28.
11. Kril JJ, Halliday GM, Svoboda MD, Cartwright H (1997). The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79, 983-998.
12. Mattson MP, Magnus T (2006). Ageing and neuronal vulnerability. Nature Reviews Neuroscience 7, 278-294.
13. Miguel-Hidalgo JJ, Wei J, Andrew M, Overholser JC, Jurjus G, Stockmeier CA, Rajkowska G (2002). Glia pathology in the prefrontal cortex in alcohol dependence with and without depressive symptoms. Biological Psychiatry 52, 1121-1133.
14. Nowoslawski L, Klocke BJ, Roth KA (2005). Molecular regulation of acute ethanol-induced neuron apoptosis. Journal of Neuropathology and Experimental Neurology 64, 490-497.
15. Okouchi M, Ekshyyan O, Maracine M, Aw TY (2007). Neuronal apoptosis in neurodegeneration. Antioxidants & Redox Signaling 9, 1059-1096.
16. Rajgopal Y, Chetty CS, Vemuri MC (2003). Differential modulation of apoptosis-associated proteins by ethanol in rat cerebral cortex and cerebellum. European Journal of Pharmacology 470, 117-124.
17. Sheedy D, Garrick T, Dedova I, Hunt C, Miller R, Sundqvist N, Harper C. (2008). An Australian Brain Bank: a critical investment with a high return! Cell and Tissue Banking 9, 205-216.
18. Sullivan EV, Pfefferbaum A (2005). Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology (Berlin) 180, 583-594.
19. Sumrejkanchanakij P, Tamamori-Adachi M, Matsunaga Y, Eto K, Ikeda MA (2003). Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons. Oncogene 22, 8723-8730.
20. Yakovleva T, Marinova Z, Kuzmin A, Seidah NG, Haroutunian V, Terenius L, Bakalkin G (2007). Dysregulation of dynorphins in Alzheimer disease. Neurobiology of Aging 28, 1700-1708.
21. Young C, Roth KA, Klocke BJ, West T, Holtzman DM, Labruyere J, Qin YQ, Dikranian K, Olney JW (2005). Role of caspase-3 in ethanol-induced developmental neurodegeneration. Neurobiology of Disease 20, 608-614.