Fetuin-A and BMD in older persons: The health aging and body composition (Health ABC) study

Journal of Bone and Mineral Research

Volumn 24, Issue 3, 2009, Pages 514-521

  Ix, Joachim H ^a,b   Wassel, Christina L ^c,d   Bauer, Douglas C ^d   Toroian, Damon ^e   Tylavsky, Frances A ^f   Cauley, Jane A ^g   Harris, Tamara B ^h   Price, Paul A ^e   Cummings, Steven R ^i,j   Shlipak, Michael G ^d,k  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^g UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^h National Institute of Aging   (United States)

ⁱ CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^j San Francisco Coordinating Center   (United States)

^k SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

BMD; Elderly; Fetuin A

Indexed keywords

ALCOHOL; C REACTIVE PROTEIN; CALCIUM; ESTROGEN; FETUIN A;

AGED; AGING; ALCOHOL CONSUMPTION; ARTICLE; BODY COMPOSITION; BODY MASS; BONE DENSITY; COMMUNITY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FEMUR NECK; FRACTURE; HEALTH; HIP; HUMAN; LINEAR REGRESSION ANALYSIS; LUMBAR SPINE; MALE; MULTIVARIATE ANALYSIS; PHYSICAL ACTIVITY; PROTEIN BLOOD LEVEL; RACE; RANDOM SAMPLE; RISK ASSESSMENT; SEX; TOBACCO; VITAMIN SUPPLEMENTATION;

AGED; AGING; BLOOD PROTEINS; BODY COMPOSITION; BONE DENSITY; DEMOGRAPHY; FEMALE; HEALTH; HUMANS; MALE; SEX CHARACTERISTICS;

EID: 61849173556     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.081017     Document Type: Article

References (41)

1. National Osteoporosis Foundation 2002 America's Bone Health: The State of Osteoporosis and Low Bone Mass in Our Nation. National Osteoporosis Foundation, Washington, DC, USA.
2. Johnell O, Kanis JA 2006 An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726-1733.
3. Randell AG, Nguyen TV, Bhalerao N, Silverman SL, Sam-brook PN, Eisman JA 2000 Deterioration in quality of life following hip fracture: A prospective study. Osteoporos Int 11:460-466.
4. Gordon PC 1971 The probability of death following a fracture of the hip. Can Med Assoc J 105:47-51, passim.
5. Ketteler M, Vermeer C, Wanner C, Westenfeld R, Jahnen-Dechent W, Floege J 2002 Novel insights into uremic vascular calcification: Role of matrix Gla protein and alpha-2-Here-mans Schmid glycoprotein/fetuin. Blood Purif 20:473-476.
6. Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA 2006 Fetuin-A and kidney function in persons with coronary artery disease-data from the Heart and Soul Study. Nephrol Dial Transplant 21:2144-2151.
7. Price PA, Thomas GR, Pardini AW, Figueira WF, Caputo JM, Williamson MK 2002 Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats. J Biol Chem 277:3926-3934.
8. Heiss A, DuChesne A, Denecke B, Grotzinger J, Yamamoto K, Renne T, Jahnen-Dechent W 2003 Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. J Biol Chem 278:13333-13341.
9. Quelch KJ, Cole WG, Melick RA 1984 Noncollagenous proteins in normal and pathological human bone. Calcif Tissue Int 36:545-549.
10. Dickson IR, Poole AR, Veis A 1975 Localisation of plasma alpha2HS glycoprotein in mineralising human bone. Nature 256:430-432.
11. Wendel M, Heinegard D, Franzen A 1993 A major non-col-lagenous 62 kDa protein from rat bone mineralized matrix is identical to pp63 a phosphorylated glycoprotein from liver. Matrix 13:331-339.
12. Mizuno M, Farach-Carson MC, Pinero GJ, Fujisawa R, Brunn JC, Seyer JM, Bousfield GR, Mark MP, Butler WT 1991 Identification of the rat bone 60K acidic glycoprotein as alpha 2HS-glycoprotein. Bone Miner 13:1-21.
13. Brandenburg V, Kruger T, Westenfeld R, Schafer C, Jahnen-Dechent W, Floege J, Martin D, Shalhoub V, Ketteler M 2007 Administration of calcimimmetic AMG641 improves osteomalacia in fetuin-A-/- mice with mild renal insufficiency. Am Soc Nephrol [abstract].
14. Ashton BA, Smith R 1980 Plasma alpha 2HS-glycoprotein concentration in Paget's disease of bone: Its possible significance. Clin Sci (Lond) 58:435-438.
15. Dickson IR, Bagga M, Paterson CR 1983 Variations in the serum concentration and urine excretion of alpha 2HS-glycoprotein, a bone-related protein, in normal individuals and in patients with osteogenesis imperfecta. Calcif Tissue Int 35:16-20.
16. Price PA, June HH, Hamlin NJ, Williamson MK 2004 Evidence for a serum factor that initiates the re-calcification of demineralized bone. J Biol Chem 279:19169-19180.
17. Toroian D, Lim JE, Price PA 2007 The size exclusion characteristics of type I collagen: Implications for the role of noncollagenous bone constituents in mineralization. J Biol Chem 282:22437-22447.
18. Toroian D, Price PA 2008 The essential role of fetuin in the serum-induced calcification of collagen. Calcif Tissue Int 82:116-126.
19. Melton LJ, III, Looker AC, Shepherd JA, O'Connor MK, Achenbach SJ, Riggs BL, Khosla S 2005 Osteoporosis assessment by whole body region vs. site-specific DXA. Osteoporos Int 16:1558-1564.
20. Baran D, Leahey D, von Stetten E 1994 Clinical evaluation of a fourth generation fanbeam DXA system. J Bone Miner Res 10:S374.
21. Fuerst T, Gluer CC, Genant H 1995 Performance evaluation of a new bone densitometer: Hologic QDR 4500. J Am Stat Assoc 10-.S370.
22. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D 1999 A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461-470.
23. Pahor M, Chrischilles EA, Guralnik JM, Brown SL, Wallace RB, Carbonin P 1994 Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol 10:405-411.
24. Sarnak MJ, Katz R, Stehman-Breen CO, Fried LF, Jenny NS, Psaty BM, Newman AB, Siscovick D, Shlipak MG 2005 Cys-tatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med 142:497-505.
25. Vittinghoff E, Glidden DV, Shiboski SC, McCulloch CE 2005 Regression Methods in Biostatistics. Springer Science + Business Media, New York, NY, USA.
26. Hamlin NJ, Price PA 2004 Mineralization of decalcified bone occurs under cell culture conditions and requires bovine serum but not cells. Calcif Tissue Int 75:231-242.
27. Price PA, Lim JE 2003 The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex. J Biol Chem 278:22144-22152.
28. Ketteler M, Bongartz P, Westenfeld R, Wildberger JE, Mahnken AH, Bohm R, Metzger T, Wanner C, Jahnen-Dechent W, Floege J 2003 Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: A cross-sectional study. Lancet 361:827-833.
29. Ruffoni D, Fratzl P, Roschger P, Klaushofer K, Weinkamer R 2007 The bone mineralization density distribution as a fingerprint of the mineralization process. Bone 40:1308-1319.
30. van der Linden JC, Birkenhager-Frenkel DH, Verhaar JA, Weinans H 2001 Trabecular bone's mechanical properties are affected by its non-uniform mineral distribution. J Biomech 34:1573-1580.
31. Johnson RC, Leopold JA, Loscalzo J 2006 Vascular calcification: Pathobiological mechanisms and clinical implications. Circ Res 99:1044-1059.
32. Giachelli CM, Jono S, Shioi A, Nishizawa Y, Mori K. Morii H 2001 Vascular calcification and inorganic phosphate. Am J Kidney Dis 38-.S34-S37.
33. Reynolds JL, Skepper JN, McNair R, Kasama T, Gupta K, Weissberg PL, Jahnen-Dechent W, Shanahan CM 2005 Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol 16:2920-2930.
34. Anderson HC 2003 Matrix vesicles and calcification. Curr Rheumatol Rep 5:222-226.
35. Fiore CE, Celotta G, Politi GG, Di Pino L, Castelli Z, Mangiafico RA, Signorelli SS, Pennisi P 2007 Association of high alpha2-Heremans-Schmid glycoprotein/fetuin concentration in serum and intima-media thickness in patients with atherosclerotic vascular disease and low bone mass. Atherosclerosis 195:110-115.
36. Lim P, Collet JP, Moutereau S, Guigui N, Mitchell-Heggs L, Loric S, Bernard M, Benhamed S. Montalescot G, Rande JL, Gueret P 2007 Fetuin-A is an independent predictor of death after ST-elevation myocardial infarction. Clin Chem 53:1835-1840.
37. Donaldson LJ, Cook A, Thomson RG 1990 Incidence of fractures in a geographically defined population. J Epidemiol Community Health 44:241-245.
38. Demetriou M, Binkert C, Sukhu B, Tenenbaum HC, Dennis JW 1996 Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist. J Biol Chem 271:12755-12761.
39. Mathews ST, Singh GP, Ranalletta M, Cintron VJ, Qiang X, Goustin AS, Jen KL, Charron MJ, Jahnen-Dechent W, Grunberger G 2002 Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes 51:2450-2458.
40. Ix JH, Shlipak MG, Sarnak MJ, Beck GJ, Greene T, Wang X, Kusek JW, Collins AJ, Levey AS, Menon V 2007 Fetuin-A is not associated with mortalitv in chronic kidney disease. Kidney Int 72:1394-1399.
41. Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA 2007 Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: Data from the Heart and Soul Study. Circulation 115:2533-2539.