A randomized double-blind trial of intravenous immunoglobulin for pemphigus

Journal of the American Academy of Dermatology

Volumn 60, Issue 4, 2009, Pages 595-603

  Amagai, Masayuki ^a   Ikeda, Shigaku ^b   Shimizu, Hiroshi ^c   Iizuka, Hajime ^d   Hanada, Katsumi ^e   Aiba, Setsuya ^f   Kaneko, Fumio ^g   Izaki, Seiichi ^h   Tamaki, Kunihiko ⁱ   Ikezawa, Zenro ^j   Takigawa, Masahiro ^k   Seishima, Mariko ^l   Tanaka, Toshihiro ^m   Miyachi, Yoshiki ⁿ   Katayama, Ichiro ^o   Horiguchi, Yuji ^p   Miyagawa, Sachiko ^q   Furukawa, Fukumi ^r   Iwatsuki, Keiji ^s   Hide, Michihiro ^t   Tokura, Yoshiki ^u   Furue, Masutaka ^v   Hashimoto, Takashi ^w   Ihn, Hironobu ^x   Fujiwara, Sakuhei ^y   Nishikawa, Takeji ^a   Ogawa, Hideoki ^b   Kitajima, Yasuo ^z   Hashimoto, Koji ^aa   more..

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d ASAHIKAWA MEDICAL COLLEGE   (Japan)

^e HIROSAKI UNIVERSITY   (Japan)

^f TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^h SAITAMA MEDICAL UNIVERSITY   (Japan)

ⁱ UNIVERSITY OF TOKYO   (Japan)

^j YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^k HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^l OGAKI MUNICIPAL HOSPITAL   (Japan)

^m SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

ⁿ KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^o OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^p OSAKA RED CROSS HOSPITAL   (Japan)

^q NARA MEDICAL UNIVERSITY   (Japan)

^r WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^s OKAYAMA UNIVERSITY   (Japan)

^t HIROSHIMA UNIVERSITY   (Japan)

^u UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^v KYUSHU UNIVERSITY   (Japan)

^w KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^x KUMAMOTO UNIVERSITY   (Japan)

^y OITA UNIVERSITY   (Japan)

^z GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^aa EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DESMOGLEIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PLACEBO; PREDNISOLONE; STEROID;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE EXACERBATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PEMPHIGUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; TREATMENT RESPONSE;

DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOLOGIC FACTORS; MALE; MIDDLE AGED; PEMPHIGUS; TIME FACTORS;

EID: 61849168566     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2008.09.052     Document Type: Article

References (24)

1. Amagai M. Pemphigus. In: Dermatology. 2nd ed. Bolognia JL, Jorizzo JL, Rapini RP, Callen JP, Horn TD, Mancini AJ, et al, eds. London: Mosby Elsevier; 2008. pp. 417-29.
2. Tappeiner G., and Steiner A. High-dosage intravenous gamma globulin: therapeutic failure in pemphigus and pemphigoid. J Am Acad Dermatol 20 (1989) 684-685
3. Gürcan H.M., and Ahmed A.R. Frequency of adverse events associated with intravenous immunoglobulin therapy in patients with pemphigus or pemphigoid. Ann Pharmacother 41 (2007) 1604-1610
4. Segura S., Iranzo P., Martínez-de Pablo I., Mascaro Jr. J.M., Alsina M., Herrero J., et al. High-dose intravenous immunoglobulins for the treatment of autoimmune mucocutaneous blistering diseases: evaluation of its use in 19 cases. J Am Acad Dermatol 56 (2007) 960-967
5. Ahmed A.R., Spigelman Z., Cavacini L.A., and Posner M.R. Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N Engl J Med 355 (2006) 1772-1779
6. Sami N., Qureshi A., Ruocco E., and Ahmed A.R. Corticosteroid-sparing effect of intravenous immunoglobulin therapy in patients with pemphigus vulgaris. Arch Dermatol 138 (2002) 1158-1162
7. Bystryn J.C., Jiao D., and Natow S. Treatment of pemphigus with intravenous immunoglobulin. J Am Acad Dermatol 47 (2002) 358-363
8. Ahmed A.R. Intravenous immunoglobulin therapy in the treatment of patients with pemphigus vulgaris unresponsive to conventional immunosuppressive treatment. J Am Acad Dermatol 45 (2001) 679-690
9. Shimanovich I., Nitschke M., Rose C., Grabbe J., and Zillikens D. Treatment of severe pemphigus with protein A immunoadsorption, rituximab and intravenous immunoglobulins. Br J Dermatol 158 (2008) 382-388
10. Ikeda S., Imamura S., Hashimoto I., Morioka S., Sakuma M., and Ogawa H. History of the establishment and revision of diagnostic criteria, severity index and therapeutic guidelines for pemphigus in Japan. Arch Dermatol Res 295 Suppl (2003) S12-S16
11. Harman K.E., Albert S., and Black M.M. Guidelines for the management of pemphigus vulgaris. Br J Dermatol 149 (2003) 926-937
12. Ahmed A.R. Consensus statement on the use of intravenous immunoglobulin therapy in the treatment of autoimmune mucocutaneous blistering diseases. Arch Dermatol 139 (2003) 1051-1059
13. Mydlarski P.R., Ho V., and Shear N.H. Canadian consensus statement on the use of intravenous immunoglobulin therapy in dermatology. J Cutan Med Surg 10 (2006) 205-221
14. Amagai M., Komai A., Hashimoto T., Shirakata Y., Hashimoto K., Yamada T., et al. Usefulness of enzyme-linked immunosorbent assay (ELISA) using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus. Br J Dermatol 140 (1999) 351-357
15. Cheng S.W., Kobayashi M., Tanikawa A., Kinoshita-Kuroda K., Amagai M., and Nishikawa T. Monitoring disease activity in pemphigus with enzyme-linked immunosorbent assay using recombinant desmoglein 1 and 3. Br J Dermatol 147 (2002) 261-265
16. Liang J.T., Huang K.C., Lai H.S., Lee P.H., and Jeng Y.M. Oncologic results of laparoscopic versus conventional open surgery for stage II or III left-sided colon cancers: a randomized controlled trial. Ann Surg Oncol 14 (2007) 109-117
17. Demetri G.D., van Oosterom A.T., Garrett C.R., Blackstein M.E., Shah M.H., Verweij J., et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomized controlled trial. Lancet 368 (2006) 1329-1338
18. Bowrey S., Hamer J., Bowler I., Symonds C., and Hall J.E. A comparison of 0.2 and 0.5 mg intrathecal morphine for postoperative analgesia after total knee replacement. Anaesthesia 60 (2005) 449-452
19. Lerman J., Nolan J., Eyres R., Schily M., Stoddart P., Bolton C.M., et al. Efficacy, safety, and pharmacokinetics of levobupivacaine with and without fentanyl after continuous epidural infusion in children: a multicenter trial. Anesthesiology 99 (2003) 1166-1174
20. Seymour R.A., Frame J., Negus T.W., Hawkesford J.E., Marsden J., and Matthew I.R. The comparative efficacy of aceclofenac and ibuprofen in postoperative pain after third molar surgery. Br J Oral Maxillofac Surg 36 (1998) 375-379
21. Avgerinos A., Nevens F., Raptis S., and Fevery J. Early administration of somatostatin and efficacy of sclerotherapy in acute esophageal variceal bleeds: the European acute bleeding esophageal variceal episodes (ABOVE) randomized trial. Lancet 350 (1997) 1495-1499
22. Kazatchkine M.D., and Kaveri S.V. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 345 (2001) 747-755
23. Zhu K.Y., Feferman T., Maiti P.K., Souroujon M.C., and Fuchs S. Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms. J Neuroimmunol 176 (2006) 187-197
24. Joly P., Mouquet H., Roujeau J.C., D'Incan M., Gilbert D., Jacquot S., et al. A single cycle of rituximab for the treatment of severe pemphigus. N Engl J Med 357 (2007) 545-552