Reduced conduction reserve of the propagating cardiac impulse in the diabetic rat heart: A model study

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Volumn , Issue , 2008, Pages 5926-5929

  Ghaly, H ^a   Boyle, P ^a   Vigmond, E ^a   Nygren, A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

RATS;

ACTION POTENTIALS; CONDUCTION VELOCITY; ELECTRICAL COUPLING; GAP JUNCTION PROTEINS; GAP JUNCTIONS; INTERCELLULAR COUPLINGS; LATERALIZATION; MYOCYTE MODELING;

VELOCITY;

ACTION POTENTIAL; ANIMAL; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; DIABETIC ANGIOPATHY; HEART MUSCLE CONDUCTION SYSTEM; HUMAN; NERVE CONDUCTION; PATHOPHYSIOLOGY; RAT;

ACTION POTENTIALS; ANIMALS; COMPUTER SIMULATION; DIABETIC ANGIOPATHIES; HEART CONDUCTION SYSTEM; HUMANS; MODELS, CARDIOVASCULAR; NEURAL CONDUCTION; RATS;

EID: 61849148220     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/iembs.2008.4650564     Document Type: Conference Paper

References (9)

1. A. Nygren, M. Olson, K. Chen, T. Emmett, G. Kargacin, and Y. Shimoni, "Propagation of the Cardiac Impulse in the Diabetic Rat Heart: Reduced Conduction Reserve," Journal of Physiology. vol. 580, no. 2, pp 543-560, Sept. 2007.
2. C. Lengyel, L. Virag, P. Kovacs, A. Kristof, P. Pacher, E. Kocsis, Z. Koltay, P. Nanasi, M. Toth, V. Kecskemeti, J. Papp, A. Varro, and N. Jost, "Role of slow delayed rectifier K+-current in QT prolongation in the alloxan-induced diabetic rabbit heart," Scandinavian Physiological Society, vol. 192, no 3, pp 359-368, Aug. 2007.
3. E. Vigmond, and C. Clements, "Construction of a Computer Model to Investigate Sawtooth effects in the Purkinje System," IEEE Transaction on Biomedical Engineering. vol. 45, no 3, pp 389-399, Mar. 2007.
4. G. Fonarow, "An approach to heart failure and diabetes mellitus," American Journal of Cardiology. vol. 96, no 4A, pp 47E-52E, Aug. 2005.
5. J. Suzuki, H. Tsubone, and S. Sugano, "Characteristics of ventricular activation and recovery patterns in the rat," Journal of veterinary medical science. vol. 54, no 4, pp 711-716, Aug. 1992.
6. K. Abo, Y. Ishida, R. Yoshida, T. Hozumi, H. Ueno, H. Shiotani, K. Matsunaga, and T. Kazumi, "Torsade de Pointes in NIDDM with long QT intervals," Diabetes Car. vol. 19, no 9, pp 1010-1018, Sept. 1996.
7. S. Pandit, R. Clark, W. Giles, and S. Demir, "A Mathematical model of Action Potential Heterogeneity in Adult Rat Left Ventricular Myocytes," Biophysical Journal. vol. 81, no 6, pp 3029-3051, Aug. 2001.
8. S. Pandit, W. Giles, and S Demir, "A Mathematical Model of the Electrophysiological Alterations in Rat Ventricular Myocytes in Type-I Diabetes," Biophysical Journal. vol. 84, no 2, pp 832-841, Feb. 2003.
9. X. Lin, M Crye, and R. Veenstra, "Regulation of Connexin43 Gap Junctional Conductance by Ventricular Action Potentials" Circulation Research. Vol. 93, no 6, pp e63-e73, Aug. 2003