Erythropoiesis once more HIF!

Blood

Volumn 112, Issue 4, 2008, Pages 931-932

  Fandrey, Joachim ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANEMIA; BONE MARROW; CELL INTERACTION; ENDOTHELIUM CELL; ERYTHROPOIESIS; GENE MUTATION; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 61849140718     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-05-158451     Document Type: Note

References (6)

1. Fandrey J, Gorr TA, Gassmann M. Regulating cellular oxygen sensing by hydroxylation. Cardiovasc Res. 2006;71: 642-651.
2. 2 tension. Proc Natl Acad Sci USA. 1995;92:5510-5514.
3. Rankin EB, Biju MP, Liu Q, et al. Hypoxia-inducible factor-2 (HIF-2)regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068-1077.
4. Scortegagna M, Ding K, Zhang Q, et al. HIF-2α regulates murine hematopoietic development in an erythropoietin-dependent manner. Blood. 2005;105:3133-3140.
5. Percy MJ, Furlow PW, Lucas GS, et al. Again-of-function mutation in the HIF2α gene in familial erythrocytosis. N Engl J Med. 2008;358:162-168.
6. Frohna PA, Milwee S, Pinkett J, et al. Preliminary results from a randomized, single-blind, placebo-controlled trial of FG-4592, a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in subjects with CKD anemia. 2007; http://www.abstracts2view.com/asn/view.php?nu =ASN07L1-4658a.