Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells

Cell Research

Volumn 19, Issue 3, 2009, Pages 358-369

  Jani, Tanvi S ^a   Gobejishvili, Leila ^a   Hote, Prachi T ^a   Barve, Aditya S ^a   Joshi Barve, Swati ^a   Kharebava, Giorgi ^a   Suttles, Jill ^a   Chen, Theresa ^a   McClain, Craig J ^a,b   Barve, Shirish ^a  

^a University of Louisville School of Medicine   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Caspase 8; FADD; FasL; Methionine adenosyltransferase; S adenosylmethionine

Indexed keywords

CASPASE 3; CASPASE 8; CFLAR PROTEIN, HUMAN; CYCLOLEUCINE; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; MAT2A PROTEIN, HUMAN; METHIONINE ADENOSYLTRANSFERASE; PROTEIN BID; S ADENOSYLMETHIONINE;

APOPTOSIS; ARTICLE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; HUMAN; INTRACELLULAR SPACE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; SERODIAGNOSIS; T CELL LEUKEMIA;

APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CASPASE 8; CELL SURVIVAL; CYCLOLEUCINE; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; ENZYME ACTIVATION; FAS LIGAND PROTEIN; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; INTRACELLULAR SPACE; LEUKEMIA, T-CELL; MEMBRANE POTENTIAL, MITOCHONDRIAL; METHIONINE ADENOSYLTRANSFERASE; NEUTRALIZATION TESTS; S-ADENOSYLMETHIONINE;

EID: 61849123226     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2008.314     Document Type: Article

References (41)

1. Cantoni GL. S-adenosylmethionine: a new intermediate formed enzymatically from L-methionine and adenosine triphosphate. J Biol Chem 1953; 204:403-416.
2. Mato JM, Alvarez L, Ortiz P, Pajares MA. S-adenosylmethionine synthesis: molecular mechanisms and clinical implications. Pharmacol Ther 1997; 73:265-280.
3. Bottiglieri T. S-adenosyl-L-methionine (SAMe): from the bench to the bedside-molecular basis of a pleiotropic molecule. Am J Clin Nutr 2002; 76 Suppl:1151S-1157S.
4. Kotb M, Geller AM. Methionine adenosyltransferase: structure and function. Pharmacol Ther 1993; 59:125-143.
5. De La Rosa J, Ostrowski J, Hryniewicz MM, et al. Chromosomal localization and catalytic properties of the recombinant α subunit of human lymphocyte methionine adenosyltransferase. J Biol Chem 1995; 270:21860-21868.
6. Halim AB, LeGros L, Chamberlin ME, Geller A, Kotb M. Regulation of the human MAT2A gene encoding the methionine adenosyltransferase, MAT II: gene organization, promoter characterization and identification of a site in the proximal promoter that is essential for its activity. J Biol Chem 2001; 276:9784-9791.
7. LeGros L, Halim AB, Chamberlin ME, Geller A, Kotb M. Regulation of the human MAT2B gene encoding the regulatory β subunit of methionine adenosyltransferase, MAT II. J Biol Chem 2001; 276:24918-24924.
8. Kotb M, Kredich NM. S-adenosylmethionine synthetase from human lymphocytes. Purification and characterization. J Biol Chem 1985; 260:3923-3930.
9. De La Rosa J, LeGros Jr HL, Geller AM, Kotb M. Changes in the relative amount of subunits of methionine adenosyltransferase in human lymphocytes upon stimulation with a polyclonal T cell mitogen. J Biol Chem 1992; 267:10699-10704.
10. LeGros Jr HL, Geller AM, Kotb M. Differential regulation of methionine adenosylmethionine transferase in superantigen and mitogen stimulated human T lymphocytes. J Biol Chem 1997; 272:16040-16047.
11. Zeng Z, Yang H, Huang ZZ, Chen C, Wang J, Lu SC. The role of c-Myb in the up-regulation of methionine adenosyltransferase 2A expression in activated Jurkat cells. Biochem J 2001; 353 Pt 1:163-168.
12. Sufrin JR, Coulter AW, Talalay P. Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. IV. Further mono-, bi-and tricyclic amino acids. Mol Pharmacol 1978; 15:661-677.
13. Lombardini JB, Sufrin JR. Chemotherapeutic potential of methionine analogue inhibitors of tumor derived methionine adenosyltransferases. Biochem Pharmacol 1983; 32:489-495.
14. Brunner T, Wasem C, Torgler R, Cima I, Jakob S, Corazza N. Fas (CD95/APO-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology. Semin Immunol 2003; 15:167-176.
15. Chinnaiyan AM, Tepper CG, Seldin MF, et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 1996; 271:4961-4965.
16. Medema JP, Scaffidi C, Kischkel FC, et al. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 1997; 16:2794-2804.
17. Peter ME, Krammer PH. The CD95 (APO-l/Fas) DISC and beyond. Cell Death Differ 2003; 10:26-35.
18. Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997; 388:190-195.
19. Sharp DA, Lawrence DA, Ashkenazi A. Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.J Biol Chem 2005; 280:19401-19409.
20. Krueger A, Baumann S, Krammer PH, Kirchoff S. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol 2001; 21:8247-8254.
21. Thome M, Tschopp J. Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol 2001; 1:50-58.
22. Rasper DM, Vaillancourt JP, Hadano S, et al. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death Differ 1998; 5:271-288.
23. Schmitz I, Weyd H, Krueger A, et al. Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIP(short). J Immunol 2004; 172:2194-2200.
24. Scaffidi C, Fulda S, Srinivasan A, et al. Two CD95 (APO-1/ Fas) signaling pathways. EMBO J 1998; 17:1675-1687.
25. Li H, Zhu X, Xu C, Yuan J. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apopto sis.Cell1998; 94:491-501.
26. Bremer E, Samplonius DF, Peipp M, et al. Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7. Cancer Res 2005; 65:3380-3388.
27. Jung KC, Kim NH, Park WS, Park SH, Bae Y. The CD99 signal enhances Fas-mediated apoptosis in the human leukemic cell line, Jurkat. FEBS Lett 2003; 554:478-484.
28. Friesen C, Herr I, Krammer PH, Debatin KM. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug induced apoptosis in leukemic cells. Nat Med 1996; 2:574-577.
29. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995; 270:1189-1192.
30. Peter ME, Kischkel FC, Scheuerpflug CG, Medema JP, Debatin KM, Krammer PH. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase-8) to the CD95 death-inducing signaling complex. Eur J Immunol 1997; 27:1207-1212.
31. Mathias S, Leitz A, Anagnostopoulos I, et al. c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis. J Exp Med 2004; 199:1041-1052.
32. Dutton A, O'Neil JD, Milner AE, et al. Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death. Proc Natl Acad Sci USA 2004; 101:6611-6616.
33. Krueger A, Fas SC, Giaisi M, et al. HTLV-1 tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP). Blood 2006; 107:3933-3939.
34. Okamoto K, Fujisawa J, Reth M, Yonehara S. Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NF-kappaB. Genes Cells 2006; 11:177-191.
35. Esteller M, Corn PG, Baylin SB, Hemran JG. A gene hyperm-ethylation profile of human cancer. Cancer Res 2001; 61:3225-3229.
36. Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science 2001; 293:1068-1070.
37. Yasunaga J, Taniguchi Y, Nosak K, et al. Identification of aberrantly methylated genes in association with adult T-cell leukemia. Cancer Res 2004; 64:6002-6009.
38. Hopkins-Donaldson S, Zielger A, Kurtz S, et al. Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation. Cell Death Differ 2003; 10:356-364.
39. Song Z, Chen T, Deaciuc IV, et al. Modulation of endotoxin stimulated interleukin-6 production in monocytes and kupffer cells by S-adenosylmethionine (SAMe). Cytokine 2004; 28:214-223.
40. McClowskey TW, Chavan S, Lakshmi Tamma SM, Pahwa S. Comparison of seven quantitative assays to assess lymphocytic cell death during HIV infection: measurement of induced apoptosis in anti-Fas treated Jurkat cells and spontaneous apoptosis in peripheral blood mononuclear cells from children infected with HIV. AIDS Res Hum Retroviruses 1998; 14:1413-1422.
41. s and induces caspase8-dependent cell death in Jurkat T lymphocytes. Cell Death Differ 2005; 12:233-242.