Response to keshava et al. (2008)

Chemical Research in Toxicology

Volumn 22, Issue 1, 2009, Pages 10-12

  Swenberg, James A ^a   Starr, Thomas B ^b   Albertini, Richard J ^c   Walker, Vernon E ^d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b TBS Associates   (United States)

^c UNIVERSITY OF VERMONT   (United States)

^d BioMosaics Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; BIOLOGICAL MARKER; CHEMICAL AGENT; DNA; ETHYLENE OXIDE; GLOBIN; GUANINE DERIVATIVE; MESYLIC ACID ETHYL ESTER; PHOSPHATE;

BRAIN TISSUE; CHEMICAL MUTAGENESIS; CHROMOSOME; DETOXIFICATION; DNA REPAIR; DOSE RESPONSE; EXPOSURE; GENE MUTATION; LETTER; LUNG PARENCHYMA; MUTAGENIC ACTIVITY; MUTANT; MUTATION RATE; NONHUMAN; NONLINEAR REGRESSION ANALYSIS; OXYGEN SATURATION; RISK ASSESSMENT; SCALE UP; SPLEEN; TOXICOLOGY;

EID: 61849121764     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx800438g     Document Type: Letter

References (13)

1. Keshava, N., Chen, C., White, P., Sonawane, B., and Bussard, D. (2009) Biomarkers in toxicology and risk assessment: Informing critical dose-response relationships by Swenberg et al., 2008. Chem. Res. Toxicol. 22, 8-10.
2. Swenberg, J. A., Fryar-Tita, E., Jeong, Y. C., Boysen, G., Starr, T., Walker, V. E., and Albertini, R. J. (2008) Biomarkers in toxicology and risk assessment: Informing critical dose-response relationships. Chem. Res. Toxicol. 21, 253-265.
3. Abramsson-Zetterberg, L. (2003) The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mutat. Res. 535, 215-222.
4. Zeiger, E., Recio, L., Fennell, T. R., Haseman, J. K., Snyder, R. W., and Friedman, M. (2008) Investigation of the low-dose response in the in vivo induction of micronuclei and adducts by acrylamide. Toxicol. Sci.
5. Walker, V. E., Sisk, S. C, Upton, P. B., Wong, B. A., and Recio, L. (1997) In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lad transgenic mice following inhalation exposure. Mutat. Res. 392, 211-222.
6. Walker, V. E., Wu, K. Y., Upton, P. B., Ranasinghe, A., Scheller, N., Cho, M. H., Vergnes, J. S., Skopek, T. R., and Swenberg, J. A. (2000) Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide. Carcinogenesis 21, 1661-1669.
7. Wu, K. Y., Ranasinghe, A., Upton, P. B., Walker, V. E., and Swenberg, J. A. (1999) Molecular dosimetry of endogenous and ethylene oxide- induced N7-(2-hydroxyethyl) guanine formation in tissues of rodents. Carcinogenesis 20, 1787-1792.
8. Bolt, H. M., and Filser, J. G. (1987) Kinetics and disposition in toxicology. Example: Carcinogenic risk estimate for ethylene. Arch. Toxicol. 60, 73-76.
9. Csandy, G. A., Denk, B., Pÿtz, C., Kreuzer, P. E., Kessler, W., Baur, C., Gargas, M. L., and Filser, J. G. (2000) A physiological toxicokinetic model for exogenous and endogenous ethylene and ethlyene oxide in rat, mouse, and human: Formation of 2-hydroxyethyl adducts with hemoglobin and DNA. Toxicol. Appl. Pharmacol. 165, 1-26.
10. Nivard, M. J. M., Czene, K., Segerbšck, D., and Vogel, E. W. (2003) Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to JV-7-(2-hydroxyalky-l) guanine levels in Drosophila. Mutat. Res. 529, 95-107.
11. Muller, L., Gocke, E., Larson, P., Lave, T., and Pfister, T. (2007) Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Vi-racept, Roche): Animal studies confirm toxicity threshold and absence of risk to patients.
12. Gocke, E., Muller, L., Pfister, T., and Lave, T. (2008) Risk assessment of genotoxic impurities: The case of EMS. p 97.
13. Williams, D. E., Bailey, G. S., Reddy, A., Hendricks, J. D., Oganesian, A., Orner, G. A., Pereira, C. B., and Swenberg, J. A. (2003) The rainbow trout (Oncorhynchus mykiss) tumor model: Recent applications in low-dose exposures to tumor initiators and promoters. Toxicol. Pathol. 31 (Suppl.), 58-61.