Comparison of electrically-evoked ganglion cell responses in normal and degenerate retina

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Volumn , Issue , 2008, Pages 2465-2468

  Ye, Jang Hee ^a   Kim, Kyung Hwan ^b   Goo, Yong Sook ^a  

^a Chungbuk National University   (South Korea)

^b Yonsei University Wonju   (South Korea)

Author keywords

And rd1 mouse; Multi electrode array (MEA); Retinal ganglion cell; Retinal prosthesis

Indexed keywords

ELECTRODES; MORE ELECTRIC AIRCRAFT; PROSTHETICS;

AGE-RELATED MACULAR DEGENERATION; AND RD1 MOUSE; ELECTRICAL CHARACTERISTIC; ELECTRICAL STIMULATIONS; MULTIELECTRODE ARRAYS; RETINAL GANGLION CELLS; RETINAL PROSTHESIS; RETINITIS PIGMENTOSA;

OPHTHALMOLOGY;

ANIMAL; ARTICLE; C3H MOUSE; C57BL MOUSE; COMPUTER SIMULATION; ELECTROCHEMISTRY; ELECTRODE; ELECTROSTIMULATION; EVOKED VISUAL RESPONSE; METABOLISM; METHODOLOGY; MOUSE; PATHOLOGY; PERCEPTIVE THRESHOLD; PHYSIOLOGY; RETINA; RETINA GANGLION CELL; RETINA MACULA DEGENERATION; RETINITIS PIGMENTOSA; TIME;

ANIMALS; COMPUTER SIMULATION; ELECTRIC STIMULATION; ELECTROCHEMISTRY; ELECTRODES; EVOKED POTENTIALS, VISUAL; MACULAR DEGENERATION; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; RETINA; RETINAL GANGLION CELLS; RETINITIS PIGMENTOSA; SENSORY THRESHOLDS; TIME FACTORS;

EID: 61849115833     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/iembs.2008.4649699     Document Type: Conference Paper

References (16)

1. L. Hyman, "Epidemiology of eye disease in the elderly", Eye, 1 pt2, pp. 330-341, 1987.
2. M. S. Humayun, M. Prince, Jr E. de Juan, Y. Berron, M. Moskowitz, I. B. Klock, A. H. Milam, "Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa", Investig. Ophthalmology. Vis. Sci, Vol. 40, pp. 143-148, 1999.
3. N. E. Medeiros, C. A. Curcio, "Preservation of ganglion cell layer neurons in age-related macular degeneration", Ophthalmology. Vis. Sci, Vol. 42, pp. 795-803, 2001.
4. G. M. Acland, G. D. Aguirre, J. Ray, Q. Zhang, T. S. Aleman, A. V. Cideciyan, S. E. Pearce-Kelling, V. Anand, Y. Zeng, A. M. Maguire, S. G. Jacobson, W. W. Hauswirth, J. Bennett, "Gene therapy restores vision in a canine model of childhood blindness", Nature Genetics, Vol. 28, pp. 92-95, 2001.
5. M. del Cerro, D. M. Gash, G. N. Rao, M. F. Notter, S. J. Wiegand, S. Sathi, C. del Cerro, "Retinal transplants into the anterior chamber of the rat eye", Neuroscience, Vol. 21, pp. 707-723, 1987.
6. E. Zrenner, "Will retinal implants restore vision?", Science, Vol. 295, pp. 1022-1025, 2002.
7. E. Margalit, M. Maia, J. D. Weiland, R. J. Greenberg, G. Y. Fujii, G. Torres, D. V. Piyathaisere, T. M. O'Hearn, W. Liu, G. Lazzi, G. Dagnelie, D. A. Scribner, Jr E. De Juan, M. S. Humayun, "Retinal prosthesis for the blind", Surv. Ophthalmology, Vol. 47, pp. 335-336, 2002.
8. J. F. Rizzo, J. Wyatt, J. Loewenstein, S. Kelly, D. Shire, "Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays", Invest Ophthalmol Vis Sci, Vol. 44, 5355-5361, 2003.
9. I. J. Lowenstein, S. R. Montezuma, J. F. Rizzo III, "Outer retinal degeneration: An electronic retinal prosthesis as a treatment strategy", Arch. Ophthalmology, Vol. 122, pp. 588-596, 2004.
10. J. H. Ye and Y. S. Goo, "The slow wave component of retinal activity in rd/rd mice recorded with multi-electrode array", Physiological Measurement, Vol. 28, pp. 1079-1088, 2007.
11. D. B. Farber, J. G. Flannery, C. Bowes-Rickman, "The rd mouse story: seventy years of research on an animal model of inherited retinal degeneration", Prog. Ret Eye Res., Vol. 13, pp. 31-64 1994.
12. A. Stett, W. Barth, S. Weiss, H. Haemmerle, E. Zrenner, "Electrical multisite stimulation of isolated chicken retina", Vision Research, Vol. 40 pp. 1785-1795, 2000.
13. T. M. O' Hearn, S. R. Sadda, J. D. Weiland, M. Maia, E Margalit, M. S. Humayun, "Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina.", Vision Research, Vol. 46, pp. 3198-3204, 2006.
14. C. Sekirnjak, P. Hottowy, A. Sher, W. Dabrowsky, A. M. Litke, E. J. Chichilnisky, "Electrical stimulation of mammalian retinal ganglion cells with multielectrode arrays", Journal of Neurophysiology, Vol. 95, 3311-3327, 2006.
15. S. Suzuki, M. S. Humayun, J. D. Weiland, S. Chen, E. Margalit, D. V. Piyathaisere, E. de Juan Jr, "Comparison of electrical stimulation thresholds in normal and retinal degenerated mouse retina", Japanese Journal of Ophthalmology, Vol. 48, 345-349, 2004.
16. R. J. Jensen, O. R. Ziv, J. F. Rizzo, "Thresholds for activation of rabbit retinal ganglion cells with relatively large, extracellular microelectrodes," Invest Ophthalmol Vis Sci, Vol. 46: 1486-1496, 2005.