A biological hazard of our age: Bracken fern [Pteridium aquilinum (L.) Kuhn] - A Review

Acta Veterinaria Hungarica

Volumn 57, Issue 1, 2009, Pages 183-196

  Vetter, János ^a  

^a SZENT ISTVÁN UNIVERSITY   (Hungary)

Author keywords

Animal poisoning; Bracken fern; Carcinogenic plant; Ptaquiloside; Pteridium aquilinum; Thiaminase

Indexed keywords

ANIMALIA; BOS; BOVIDAE; EQUIDAE; MUS; OVIS ARIES; PTERIDIUM AQUILINUM; RATTUS; SUIDAE;

EID: 61849110277     PISSN: 02366290     EISSN: 15882705     Source Type: Journal    
DOI: 10.1556/AVet.57.2009.1.18     Document Type: Article

References (52)

1. Agnew, M. P. and Lauren, D. R. (1991): Determination of ptaquiloside in bracken fern (Pteridium esculentum). J. Chromat. 538, 462-468.
2. Alonso-Amelot, M. E. and Avendano, M. (2002): Human carcinogenesis and bracken fern: a review of the evidence. Cur. Med. Chem. 9, 675-686.
3. Alonso-Amelot, M. E. and Oliveros, A. (2000): A method for the practical quantification and kinetic evaluation of cyanogenesis in plant material. Application to Pteridium aquilinum and Passiflora capsularis. Phytochem. Anal. 11, 309-316.
4. Alonso-Amelot, M. E., Castillo, U., Smith, B. L., Lauren, D. R. and Amelot, M. E. A. (1996): Bracken ptaquiloside in milk. Nature 382, 587.
5. Alonso-Amelot, M. E., Perez-Mena, M., Calcagno, M. P., Jaimes-Espinoza, R. and Castillo, U. (1992): Ontogenetic variation of biologically active metabolites of Pteridium aquilinum (L. Kuhn.). J. Chem. Ecol. 18, 1405-1420.
6. Asano, M., Ohkubo, C., Sasaki, A., Hirono, I., Yamada, K., Niwa, H. and Ojika, M. (1989): Acute microcirculatory changes induced by intravenous administration to rabbits of ptaquiloside, a bracken carcinogen. J. Ethnopharmac. 27, 213-220.
7. Carvalho, T., Pinto, C. and Peleteiro, M. C. (2006): Urinary bladder lesions in bovine enzootic haematuria. J. Comp. Pathol. 134, 336-346.
8. Castillo, U. F., Ojika, M., Alonso-Amelot, M. and Sakagami, Y. (1998): Ptaquiloside Z, a new toxic unstable sesquiterpene glucoside from the neotropical bracken fern Pteridium aquilinum var. caudatum. Bioorg. Med. Chem. 6, 2229-2233.
9. Castillo, U. F., Wilkins, A. L., Lauren, D. R., Smith, B. L., Towers, N. R., Alonso-Amelot, M. E. and Jaimes-Espinoza, R. (1997): Isoptaquiloside and caudatoside illudane-type sesquiterpene glucosides from Pteridium aquilinum var. caudatum. Phytochem. 44, 901-906.
10. Edwards, B. L. (1983): Poisoning by Pteridium in pregnant sows. Vet. Rec. 112, 459-460.
11. Evans, I. A. and Galpin, O. P. (1990): Bracken and leukaemia. Lancet British Edition 335, 231.
12. Evans, W. C., Evans, I. A., Humphreys, D. J., Lewin, B. and Davies, W. E. J. (1975): Induction of thiamine deficiency in sheep, with lesions similar to those of cerebrocortical necrosis. J. Comp. Pathol. 85, 253-267.
13. Evans, W. C., Widdop, B. and Harding, J. D. J. (1972): Experimental poisoning by bracken rhizomes in pigs. Vet. Rec. 90, 471-475.
14. Falbo, M. K., Reis, A. C. F., Balarin, M. R. S., Bracarense, A. P. F. R. L., Araujo-Junior, J. P., Okano, W. and Sandini, I. E. (2005): Alteracoes hematologicas, bioquimicas, urinarias e histopathologicas na intoxicacao natural em bovinos pela samambaia Pteridium aquilinum (L.) Kuhn. Ciencas Agrarias Londrina 26, 547-558.
15. Freitas, R. N., O'Connor, P. J., Prakash, A. S., Shahin, M. and Povey, A. C. (2001): Bracken (Pteridium aquilinum) induced DNA adducts in mouse tissues are different from the adduct induced by the activated form of the bracken carcinogen ptaquiloside. Biochem. Biophys. Res. Comm. 281, 589-594.
16. Galpin, O. P., Whitaker, C. J. and Whitaker, R. H. (1990): Gastric cancer in Gwynedd: possible links with bracken. Br. J. Cancer 61, 737-740.
17. Gounalan, S., Somwanshi, R., Kataria, M., Bisht, G. S., Smith, B. L. and Lauren, D. R. (1999a): Effect of bracken (Pteridium aquilinum) and dryopteris (Dryopteris juxtaposita) fern toxicity in laboratory rabbits. Ind. J. Exp. Biol. 37, 980-985.
18. Gounalan, S., Somwanshi, R., Kumar, R., Dash, S. and Devi, V. (1999b): Clinico-pathological effects of bracken fern (Pteridium aquilinum) feeding in laboratory rats. Ind. J. Anim. Sci. 69, 385-388.
19. Hadfield, P. R. H. and Dyer, A. F. (1988): Cyanogenesis in gametophytes and young sporophytes of bracken. Biochem. System. Ecol. 16, 9-13.
20. Hirono, I., Fujimoto, M., Yamada, K., Yoshida, Y. and Ikagawa, M. (1987): Induction of tumours in ACI rats given a diet containing ptaquiloside, a bracken carcinogen. J. Nat. Cancer Inst. 79, 1143-1149.
21. Hirono, I., Ito, M., Yagyu, S., Haga, M., Wakamatsu, K., Kishikawa, T., Nishikawa, O., Yamada, K., Ojika, M. and Kigoshi, J. (1993): Reproduction of progressive retinal degeneration (bright blindness) in sheep by administration of ptaquiloside contained in bracken. J. Vet. Med. Sci. 55, 979-983.
22. Konishi, T. and Ichijo, S. (1984): Experimentally induced equine bracken poisoning by thermostable antithiamine factor (SF factor) extracted from dried bracken. J. Jpn. Vet. Med. Assoc. 37, 730-734.
23. Lal Khrishna and Dawra, R. K. (1994): Bracken fern induced carcinoma in guinea pigs. Indian J. Vet. Pathol. 18, 21-26.
24. Lioi, M. B., Barbieri, R., Borzacchiello, G., Roperto, S., Santoro, A., Russo, V. and Roperto, F. (2004): Chromosome aberrations in cattle with chronic enzootic haematuria. J. Comp. Pathol. 131, 233-236.
25. Marliere, C. A., Santos, R. C., Galvao, M. A. M. and Soares, J. F. (1998): Ingestao de broto de samambaia e risco sde cancer de esofago e estomago na regiao de Ouro Preto, MG. Revista Brasiliera de Cancerologia 44, 225-229.
26. Marrs, R. H. and Watt, A. S. (2006): Biological flora of the British Isles: Pteridium aquilinum (L.) Kuhn. J. Ecol. 94, 1272-1321.
27. Meyer, P. (1989): Thiaminase activities and thiamine content of Pteridium aquilinum, Equisetum ramossisimum, Malva parviflora, Pennisetum clandestinum and Medicago sativa. Onderstepoort J. Vet. Res. 56, 145-146.
28. Niwa, H., Okija, M., Wakamatsu, K., Yamada, K., Hirono, T. and Matsushita, K. (1983): Ptaquiloside, a novel norsesquiterpene glucoside from bracken Pteridium aquilinum var. latiusculum. Tetrah. Lett. 24, 4117-4120.
29. Oelrichs, P. B., Ng, J. C. and Bartley, J. (1995): Purification of ptaquiloside, a carcinogen from Pteridium aquilinum. Phytochem. 40, 53-56.
30. Ojika, M., Wakamatsu, K., Iwa, H. and Yamada, K. (1987): Ptaquiloside, a potent carcinogen isolated from bracken fern Pteridium aquilinum var. lutiusculum: Structure elucidation based on chemical and spectral evidence and reactions with amino acids, nucleosides and nucleotides. Tetrah. Lett. 43, 5261.
31. Rao, D. S. T., Joshi, H. C., Kumar, M. and Singh, G. K. (1990): Pathological studies on brackenfern (Pteris aquilina) induced haematuria in calves and rats. Ind. J. Anim. Sci. 60, 654-656.
32. Rasmussen, L. H., Hansen, H. C. B. and Lauren, D. (2005): Sorption, degradation and mobility of ptaquiloside, a carcinogenic bracken (Pteridium sp.) constituent, in the soil environment. Chemosph. 58, 823-835.
33. Ravinsankar, R., Somvanshi, R., Tandon, S. K. and Ajit, N. (2005): Behavioural and pathological studies on laboratory rats fed with crude extract of bracken fern. Toxicol. Internat. 12, 125-128.
34. Recouso, R. C., Stocco dos Santos, R. C., Freitas, R., Santos, R. C., de Freitas, A. C., Brunner, O., Becak, W. and Lindsey, C. J. (2003): Clastogenic effect of bracken fern (Pteridium aquilinum v. arachnoideum) in peripheral lymphocytes of human consumers: preliminary data. Vet. Comp. Oncol. 1, 22-29.
35. Riet-Correa, F., Saures, M. P. and Mendez, M. del C. (1998): Intoxicacoes em equinos no Brasil. Ciencia Rural 28, 715-722.
36. Sanchez, V. A., Garcia, R. K., Alvarado, C. M., de Villegas, M. and Pru, E. P. (1999): Estudio ultrastructural de la vejiga urinaria en la hematuria enzootica bovina. Revista Cientifica Faculdad de Ciencias Veterinarias Universidad del Zulia 9, 196-204.
37. Selvaraj, P., de Britto, A. J. and Sahayaraj, K. (2005): Phytoecdysone of Pteridium aquilinum (L.) Kuhn (Dennstadtiaceae) and its pesticidal property on two major pests. Archiv. Phytopat. Plant Prot. 38, 99-105.
38. Siman, S. E., Povey, A. C., Ward, T. H., Margison, G. P. and Sheffield, E. (2000): Fern spore extracts can damage DNA. Br. J. Cancer 83, 69-73.
39. Singh, R. P., Joshi, H. C. and Kumar, M. (1987): Experimental bracken fern toxicity in calves: changes in blood and urine. Ind. J. Vet. Med. 7, 96-100.
40. Singh, S. P., Asrani, R. K., Gupa, V. K., Wadhawa, D. R. and Prasad, B. (1998): Histopathological studies on spontaneous chronic enzootic bovine hematuria in Himachal Pradesh. Ind. Vet. J. 75, 982-984.
41. Smith, B. L. (2004): Bracken fern (genus Pteridium) toxicity - a global problem. In: Acamovic, T., Stewart, C. S. and Pennycott, T. W. (eds) Poisonous Plants and Related Toxins. CAB International, Wallingford. pp. 224-240.
42. Smith, B. L., Seawright, A. A., Ng, J. C., Hertle, A. T., Thomson, J. A. and Bostock, P. D. (1994): Concentration of ptaquiloside, a major carcinogen in bracken fern (Pteridium spp.) from eastern Australia and from a cultivated worldwide collection held in Sydney, Australia. Nat. Tox. 2, 347-353.
43. Sundermann, F. M. (1987): Bracken poisoning in sheep. Austr. Vet. J. 64, 25-26.
44. Taylor, J. A. (1986): The bracken problem, a local hazard and global issue. In: Smith, R. T. and Taylor, J. A. (eds), Bracken: Ecology, Land Use and Control Technology, Parthenon Publishing Group, Carnforth. pp. 21-42.
45. Tjatur-Rasa, F. S., Saito, T. and Satok, H. (1999): The haemolytic activity of bracken extract in guinea pigs. J. Vet. Med. Sci. 61, 129-133.
46. Tripathi, S. C., Joshi, H. C. and Maheshi, K. (1989): Blood chemical changes in experimental bracken fern induced haematuria in calves. Ind. J. Anim. Sci. 59, 835-837.
47. Van der Hoeven, J. C. M., Lagerweij, W. J., Posthumus, M. A., van Veldhuizen, A. and Holterman, H. A. J. (1983): Aquilide, a new mutagen compound isolated from bracken fern (Pteridium aquilinum L.) Kuhn. Carcinogen. 4, 1587-1590.
48. Vetter, J. (1999): Poisonous plants - plant poisonings (in Hungarian) I. Gyógyszerészet 43, 80-96.
49. Villalobos-Salazar, J. (1985): Carcinogenicidad del Pteridium aquilinum y alta incidentia del cancer gastrico en Costa Rica. Revista Costa Rica Ciencies Medicine 6, 131-139.
50. Villalobos-Salazar, J., Mora, J., Meneses, A. and Pashov, B. (1995): The carcinogenic effects of bracken spores. In: Smith, R. T. and Taylor, J. A. (eds) Bracken: An Environmental Issue. International Bracken Group, Aberystwith. pp. 102-103.
51. Wang, Y. D., Xu, L. R., Wen, L. J., Ma, W. L., You, S. Z., He, K. R. and Yang, K. X. (1984): Studies on experimental bovine bracken poisoning. Acta Veterinaria et Zootechnica Sinica 15, 235-239.
52. Watson, W. A., Barlow, R. M. and Barnett, K. C. (1965): Bright blindness, a condition prevalent in Yorkshire hill sheep. Vet. Rec. 77, 1060-1069.