A software framework for multiscale and multilevel physiological model integration and simulation

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"

Volumn , Issue , 2008, Pages 5449-5453

  Erson, E Zeynep ^a   Çavuşoǧlu, M Cenk ^a  

^a Case Western Reserve University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER PROGRAMMING; INTEGRATION; INTEGRATION TESTING; PHYSIOLOGY;

ANALYSIS AND TESTING; FUNCTIONAL INFORMATION; INTEGRATION APPROACH; INTEGRATION MECHANISMS; MULTISCALE PROCESS; PHYSIOLOGICAL INFORMATIONS; PHYSIOLOGICAL PROCESS; SOFTWARE FRAMEWORKS;

PHYSIOLOGICAL MODELS;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; COMPUTER PROGRAM; COMPUTER SIMULATION; HUMAN; METHODOLOGY; PHYSIOLOGICAL PROCESS; PHYSIOLOGY; SYSTEM ANALYSIS; SYSTEMS BIOLOGY;

ANIMALS; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; PHYSIOLOGICAL PROCESSES; SOFTWARE; SOFTWARE DESIGN; SYSTEMS BIOLOGY; SYSTEMS INTEGRATION;

EID: 61849108673     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/iembs.2008.4650447     Document Type: Conference Paper

References (20)

1. A. Aderem, "Systems biology: Its practice and challenges," Cell, vol. 121, pp. 511-513, 2005.
2. H. Kitano, "Systems biology: A brief overview," Science, vol. 295, pp. 1662-1664, 2002.
3. D. Noble, "Modeling the heart-from genes to cells to the whole organ," Science, 2002.
4. R. M. Berne and M. N. Levy, Physiology. Mosby, 1998.
5. J. B. Bassingthwaighte and H. J. Chizeck, "The physiome projects and multiscale modeling," IEEE Signal Processing Magazine, 2008.
6. "Modelica, a unified object-oriented language for physical systems modeling; language specification 2.0. the modelica association, http://www.modelica.org," 2002.
7. "Mathworks Inc., Simulink, http://www.mathworks.com/products/ simulink."
8. J. T. Buck, S. Ha, E. A. Lee, and D. G. Messerschmitt, "Ptolemy: A framework for simulating and prototyping heterogeneous systems," International Journal of Computer Simulation special issue on Simulation Software Development, vol. 4, 1994.
9. "SCIRun: A scientific computing problem solving environment. scientific computing and imaging institute (sci), http://software.sci.utah.edu/ scirun.html," 2002.
10. H. Schmidt and M. Jirstrand, "Systems biology toolbox for matlab: A computational platform for research in systems biology," Bioinformatics Advance Access, vol. 22, 2005.
11. G. Higgins, B. Athey, J. Bassingthwaighte, J. Burgess, H. Champion, K. Cleary, P. Dev, J. Duncan, M. Hopmeier, D. Jenkins, C. Johnson, H. Kelly, R. Leitch, W. Lorensen, D. Metaxas, V. Spitzer, N. Vaidehi, K. Vosburgh, and R. Winslow, "Final report of the meeting "modeling & simulation in medicine: Towards an integrated framework"," Computer Aided Surgery, pp. 32-39, 2001.
12. E. J. Crampin, M. Halstead, P. Hunter, P. Nielsen, D. Noble, N. Smith, and M. Tawhai, "Computational physiology and the physiome project," Experimental Physiology, vol. 89, pp. 1-26, 2003.
13. "Physiome project, http://www.physiome.org/."
14. P. J. Hunter and T. K. Borg, "Integration from proteins to organs: the physiome project," Nature Reviews, Molecular Cell Biology, 2003.
15. "Jsim, http://www.physiome.org/jsim/."
16. S. R. Thomas, E. Abdulhay, P. Baconnier, J. Fontecave, J. P. Françoise, F. Guillaud, P. Hannaert, A. Hernandez, V. Le Rolle, P. Maziere, F. Tahi, and F. Zehraoui, "Saphir - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis," in Proceedings of the 29th Annual International Conference of the IEEE EMBS, 2007, pp. 6648-6651.
17. R. M. Berne and M. N. Levy, Principles of Physiology. Mosby, 2000.
18. X. Wang, C. W. Chan, and H. Hamilton, "Design of knowledge-based systems with the ontology-domain-system approach," in Proceedings of SEKE, 2002, pp. 15-19.
19. C. Rosse, J. L. V. Mejino, B. R. Modayur, R. M. Jakobovits, K. P. Hinshaw, and J. F. Brinkley, "Motivation and organizational principles for anatomical knowledge representation: The digital anatomist symbolic knowledge base," Journal of the American Medical Informatics Association, 1998.
20. R. Upton, "A model of the first pass passage of drugs from i.v. injection site to the heart-parameter estimates for lignocaine in the sheep," British Journal of Anasthesia, 1996.