Expression of the urokinase plasminogen activator receptor (uPAR) and its ligand (uPA) in brain tissues of human immunodeficiency virus patients with opportunistic cerebral diseases

Journal of NeuroVirology

Volumn 15, Issue 1, 2009, Pages 99-107

  Nebuloni, Manuela ^a   Cinque, Paola ^b   Sidenius, Nicolai ^b   Ferri, Angelita ^a   Lauri, Eleonora ^a   Omodeo Zorini, Elisabetta ^a   Zerbi, Pietro ^a   Vago, Luca ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Central nervous system; HIV; Immunohistochemistry; Opportunistic infection; Plasminogen activation system

Indexed keywords

UROKINASE RECEPTOR;

ARTICLE; BRAIN TISSUE; CELL ACTIVATION; CELL COUNT; CENTRAL NERVOUS SYSTEM INFECTION; CONTROLLED STUDY; CRYPTOCOCCAL MENINGITIS; CYTOMEGALOVIRUS; ENCEPHALITIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; LYMPHOCYTE COUNT; MICROGLIA; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; TOXOPLASMOSIS;

ADULT; AGED; AIDS-RELATED OPPORTUNISTIC INFECTIONS; BRAIN; BRAIN DISEASES; FEMALE; HUMANS; LIGANDS; MALE; MIDDLE AGED; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; RETROSPECTIVE STUDIES; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 61849100426     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280802400692     Document Type: Article

References (29)

1. Akenami, FO, Koskiniemi, M., Farkkila, M. and Vaheri, A. (1997) Cerebrospinal fluid plasminogen activator inhibitor-1 in patients with neurological disease. J Clin Pathol, 50, pp. 157-160.
2. Akenami, FO, Siren, V., Koskiniemi, M., Siimes, MA, Teravainen, H. and Vaheri, A. (1996) Cerebrospinal fluid activity of tissue plasminogen activator in patients with neurological diseases. J Clin Pathol, 49, pp. 577-580.
3. Alfano, M., Sidenius, N., Panzere, B., Blasi, F. and Poli, G. (2002) Urokinase-urokinase receptor interaction mediates an inhibitor signal for HIV-1 replication. Proc Natl Acad Sci U S A, 99, pp. 8862-8867.
4. Brunner, N., Nielsen, HJ, Hamers, M., Christensen, IJ, Thorlacius-Ussing, O. and Stephens, RW (1999) The urokinase plasminogen activator receptor in blood from healthy individuals and patients with cancer. APMIS, 107, pp. 160-167.
5. Cinque, P., Nebuloni, M., Santovito, ML, Price, RW, Gisslen, M., Hagberg, L., Bestetti, A., Vago, G., Lazzarin, A., Blasi, F. and Sidenius, N. (2004) The urokinase receptor is overexpressed in the AIDS dementia complex and other neurological manifestations. Ann Neurol, 55, pp. 687-694.
6. Cinque, P., Vago, L., Mengozzi, M., Torri, V., Ceresa, D., Vicenzi, E., Transidico, P., Vagani, A., Sozzoni, S., Mantovani, A., Lazzarin, A. and Poli, G. (1998) Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS, 12, pp. 1327-1332.
7. Coleman, JL, Gebbia, JA and Benach, JL (2001) Borrelia burgdoferi and other bacterial products induce expression and release of the urokinase receptor (CD87). J Immunol, 166, pp. 473-480.
8. Collen, D. (2001) Ham-Wasserman lecture: Role of the plasminogen system in fibrin-homeostasis and tissue remoldeling (American Society of Hematology Educuation Program). Hematology, 1, pp. 1-9.
9. Dekkers, PE, ten Hove, T, te Velde, AA, van Deventer, SJ and van Der Poll, T. (2000) Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia. Infect Immun, 68, pp. 2156-2160.
10. Deininger, MH, Trautmann, K., Magdolen, V., Luther, T., Schluesener, HJ and Meyermann, R. (2002) Cortical neurons of Creutzfeldt-Jakob disease patients express the urokinase-type plasminogen activator receptor. Neurosci Lett, 324, pp. 80-82.
11. Fauser, S., Deininger, MH, Kremsner, PG, Magdolen, V., Luther, T., Meyermann, R. and Schluesener, HJ (2000) Lesion associated expression of urokinase-type plasminogen activator recetor (uPAR, CD87) in human cerebral malaria. J Neuroimmunol, 111, pp. 234-240.
12. Garcia-Monco, J., Coleman, J. and Benach, J. (2002) Solubile urokinase receptor (uPAR, CD87) is present in serum and cerebrospinal fluid in patients with neurological diseases. J Neuroimmunol, 129, pp. 216-223.
13. Gveric, D., Hanemaaijer, R., Newcombe, J., van Lent, NA, Sier, CF and Cuzner, ML (2001) Plasminogen activators in multiple sclerosis lesions: implication for the infammatory response and axonal damage. Brain, 124, pp. 1978-1988.
14. Leduc, D., Beaufort, N., de Bentzmann, S., Rousselle, JC, Namane, A., Chignard, M. and Pidard, D. (2007) The Pseudomonas aeruginosa LasB metalloproteinase regulates the human urokinase-type plasminogen activator receptor through domain-specific endoproteolysis. Infect Immun, 75, pp. 3848-3858.
15. Lemstra, AW, Groen in't, Woud J, Hoozemans, J., van Haastert, ES, Rozemuller, A., Eikelenboom, P. and van Gool, W. (2007) Microglia activation in sepsis: A case-control study. J Neuroinflamm Au, 4, p. 4.
16. Madsen, CD, Ferraris, GM, Andolfo, A., Cunningham, O. and Sidenius, N. (2007) uPAR-induced cell adhesion and mgration: Vitronectin provides the key. J Cell Biol, 177, pp. 927-939.
17. Mohanam, S., Go, Y., Sawaya, R., Venkaiah, B., Mohan, PM, Kouraklis, GP, Gokaslan, ZL, Lagos, GK and Rao, JS (1999) Elevated levels of urokinase-type plasminogen activator and its receptor during tumor growth in vivo. Int J Oncol, 14, pp. 169-174.
18. Nebuloni, M., Pellegrinelli, A., Ferri, A., Tosoni, A., Bonetto, S., Zerbi, P., Boldorini, R., Vago, L. and Costanzi, G. (2000) Etiology of microglial nodules in brains of patients with acquired immunodeficiency sindrome. J NeuroVirol, 6, pp. 46-50.
19. Notter, HS (1999) Interaction between macrophages and brain microvascular endothelial cells: Role in pathogenesisof HIV-1 infection and blood-brain barrier function. J NeuroVirol, 5, pp. 659-669.
20. Ostergaard, C., Benfield, T., Lundgren, JD and Eugen-Olsen, J. (2004) Soluble urokinase receptor is elevated in cerebrospinal fluid from patients with purulent meningitis and it is associated with fatal outcome. Scand J Infect Dis, 36, pp. 14-19.
21. Ostrowski, SR, Piironen, T., Hoyer-Hansen, G., Gerstoft, J., Pedersen, BK and Ullum, H. (2005) Reduced release of intact and cleaved urokinase receptor in stimulated whole-blood cultures from human immunodeficinecy virus-1-infected patients. Scand J Immunol, 61, pp. 347-356.
22. Paul, R., Winkler, F., Bayerlein, I., Popp, B., Pfister, HW and Koedel, U. (2005) Urokinase-type plasminogen activator receptor regulates leukocytes recruitment during experimental pneumococcal meningitis. J Infect Dis, 191, pp. 776-782.
23. Plesner, T., Ralfkiaer, E., Wittrup, M., Johnsen, H., Pyke, C., Pedersen, TL, Hansen, NE and Dano, K. (1994) Expression of the receptor for urokinase-type plasminogen activator in norma and neoplastic blood cells and hematopoietic tissue. Am J Clin Pathol, 102, pp. 835-841.
24. Resnati, M., Pallavicini, I., Wang, JM, Oppenheim, J., Serhan, CN, Romano, M. and Blasi, F. (2002) The fibrinolytic receptor for urokinase activates the G protein-couples chemotactic receptor FPRL1/LXA4R. Proc Natl Acad Sci U S A, 99, pp. 1359-1364.
25. Sidenius, N., Nebuloni, M., Sala, S., Zerbi, P., Price, RW, Gisslen, M., Hagberg, L., Vago, L., Lazzarin, A., Blasi, F. and Cinque, P. (2004) Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease. J Neuroimmunol, 157, pp. 133-139.
26. Speth, C., Pichler, I., Stockl, G., Mair, M. and Dierich, MP (1998) Urokinase plasminogen activator receptor 8uPAR; CD87) expression on monocytic cells and T cells is modulated by HIV-1 infection. Immunobiology, 199, pp. 152-162.
27. Wada, M., Wada, NA, Shirono, H., Tanigichi, K., Tsuchie, H. and Koga, J. (2001) Amino-terminal fragment of urokinase-type plasminogen activator inhibits HIV-1 replication. Biochem Biophys Res Commun, 284, pp. 346-351.
28. Walker, DG, Lue, LF and Beach, TG (2002) Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains. Brain Res, 926, pp. 69-79.
29. Winkler, F., Kastenbauer, S., Koedel, U. and Pfister, HW (2002) Role of the urokinase plasminogen activator system in patients with bacterial meningitis. Neurology, 59, pp. 1350-1355.