Promotion of Nerve Regeneration in Peripheral Nerve by Short-Course FK506 after End-to-Side Neurorrhaphy

Journal of Surgical Research

Volumn 152, Issue 2, 2009, Pages 303-310

  Chen, Bin ^a   Song, Youxin ^b   Liu, Zhongjun ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

end to side neurorrhaphy; FK506; peripheral nerve; regeneration; short course

Indexed keywords

TACROLIMUS;

ADDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; END TO END ANASTOMOSIS; END TO SIDE ANASTOMOSIS; EXTENSOR DIGITORUM LONGUS MUSCLE; FEASIBILITY STUDY; FLEXION CONTRACTURE; GAIT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MICROTOME; MORPHOLOGY; MORPHOMETRICS; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE MASS; MYELIN SHEATH; NERVE FIBER; NERVE FUNCTION; NERVE REGENERATION; NERVE SURGERY; NEURORRHAPHY; NONHUMAN; PERIPHERAL NERVE; PERIPHERAL NERVE INJURY; PERONEUS NERVE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; SCIATIC NERVE; TIBIAL NERVE; TOE; TREATMENT DURATION;

ANASTOMOSIS, SURGICAL; ANIMALS; AXONS; HINDLIMB; MALE; MUSCLE, SKELETAL; NERVE REGENERATION; NEUROSURGICAL PROCEDURES; PERONEAL NERVE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SCHWANN CELLS; SCIATIC NERVE; TACROLIMUS; WALKING; WEIGHT-BEARING;

EID: 61849094242     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2008.03.032     Document Type: Article

References (37)

1. Viterbo F., Teixeira E., Hoshino K., et al. End-to-side neurorrhaphy with and without perineurium. Sao Paulo Med J 116 (1998) 1808
2. Viterbo F., Trindade J.C., Hoshino K., et al. Two end-to-side neurorrhaphies and nerve graft with removal of the epineural sheath: Experimental study in rats. Br J Plast Surg 47 (1994) 75
3. Viterbo F., Trindade J.C., Hoshino K., et al. Latero-terminal neurorrhaphy without removal of the epineural sheath. Experimental study in rats. Rev Paul Med 110 (1992) 267
4. Viterbo F., Trindade J.C., Hoshino K., et al. End-to-side neurorrhaphy with removal of the epineurial sheath: An experimental study in rats. Plast Reconstr Surg 94 (1994) 1038
5. Bertelli J.A., dos Santos A.R., and Calixto J.B. Is axonal sprouting able to traverse the conjunctival layers of the peripheral nerve?. A behavioral, motor, and sensory study of end-to-side nerve anastomosis. J Reconstr Microsurg 12 (1996) 559
6. Jaberi F.M., Abbas B.P., Nezhad S.T., et al. End-to-side neurorrhaphy: An experimental study in rabbits. Microsurgery 23 (2003) 359
7. Bertelli J.A., and Ghizoni M.F. Nerve repair by end-to-side coaptation or fascicular transfer: A clinical study. J Reconstr Microsurg 19 (2003) 313
8. Akeda K., Hirata H., Matsumoto M., et al. Regenerating axons emerge far proximal to the coaptation site in end-to-side nerve coaptation without a perineurial window using a T-shaped chamber. Plast Reconstr Surg 117 (2006) 1194
9. Wallemacq P.E., and Reding R. FK506 (tacrolimus), a novel immunosuppressant in organ transplantation: Clinical, biomedical, and analytical aspects. Clin Chem 39 (1993) 2219
10. Beris A.E., Naka K.K., Skopelitou A., et al. Functional assessment of the rat sciatic nerve following intraoperative expansion: The effect of recovery duration on behavioural, neurophysiological, and morphological measures. Microsurgery 17 (1996) 568
11. Shen N., and Zhu J. Application of sciatic functional index in nerve functional assessment. Microsurgery 16 (1995) 552
12. Bain J.R., Mackinnon S.E., and Hunter D.A. Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg 83 (1989) 129
13. McCallister W.V., Cober S.R., Norman A., et al. Using intact nerve to bridge peripheral nerve defects: An alternative to the use of nerve grafts. J Hand Surg [Am] 26 (2001) 315
14. De Sa J.M., Mazzer N., Barbieri C.H., et al. The end-to-side peripheral nerve repair. Functional and morphometric study using the peroneal nerve of rats. J Neurosci Methods 136 (2004) 45
15. Trumble T.E. Peripheral nerve transplantation: The effects of predegenerated grafts and immunosuppression. J Neural Transplant Plast 3 (1992) 39
16. Goto T., Kino T., Hatanaka H., et al. Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. Transplant Proc 19 (1987) 4
17. Gold B.G. FK506 and the role of immunophilins in nerve regeneration. Mol Neurobiol 15 (1997) 285
18. Lyons W.E., Steiner J.P., Snyder S.H., et al. Neuronal regeneration enhances the expression of the immunophilin FKBP-12. J Neurosci 15 (1995) 2985
19. Grand A.G., Myckatyn T.M., Mackinnon S.E., et al. Axonal regeneration after cold preservation of nerve allografts and immunosuppression with tacrolimus in mice. J Neurosurg 96 (2002) 924
20. Chunasuwankul R., Ayrout C., Dereli Z., et al. Low dose discontinued FK506 treatment enhances peripheral nerve regeneration. Int Surg 87 (2002) 274
21. Navarro X., Udina E., Ceballos D., et al. Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps. Muscle Nerve 24 (2001) 905
22. Becker D.B., Jensen J.N., Myckatyn T.M., et al. Effects of FKBP-12 ligands following tibial nerve injury in rats. J Reconstr Microsurg 16 (2000) 613
23. Doolabh V.B., and Mackinnon S.E. FK506 accelerates functional recovery following nerve grafting in a rat model. Plast Reconstr Surg 103 (1999) 1928
24. Jost S.C., Doolabh V.B., Mackinnon S.E., et al. Acceleration of peripheral nerve regeneration following FK506 administration. Restor Neurol Neurosci 17 (2000) 39
25. Brenner M.J., Mackinnon S.E., Rickman S.R., et al. FK506 and anti-CD40 ligand in peripheral nerve allotransplantation. Restor Neurol Neurosci 23 (2005) 237
26. Ellis R.A., Brenner M.J., Mackinnon S.E., et al. Use of mixed lymphocyte reaction to identify subimmunosuppressive FK-506 levels in mice. Microsurgery 23 (2003) 276
27. Steiner J.P., Connolly M.A., Valentine H.L., et al. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A. Nat Med 3 (1997) 421
28. Sulaiman O.A., Voda J., Gold B.G., et al. FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic schwann cell denervation. Exp Neurol 175 (2002) 127
29. Tanaka K., Fujita N., and Ogawa N. Immunosuppressive (FK506) and non-immunosuppressive (GPI1046) immunophilin ligands activate neurotrophic factors in the mouse brain. Brain Res 970 (2003) 250
30. Udina E., Ceballos D., Gold B.G., et al. FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers. Exp Neurol 183 (2003) 220
31. Jiang B.G., Yin X.F., Zhang D.Y., et al. Maximum number of collaterals developed by one axon during peripheral nerve regeneration and the influence of that number on reinnervation effects. Eur Neurol 58 (2007) 12
32. Yan J.G., Matloub H.S., Sanger J.R., et al. A modified end-to-side method for peripheral nerve repair: Large epineurial window helicoid technique versus small epineurial window standard end-to-side technique. J Hand Surg [Am] 27 (2002) 484
33. Kanje M., Arai T., and Lundborg G. Collateral sprouting from sensory and motor axons into an end to side attached nerve segment. Neuroreport 11 (2000) 2455
34. Rovak J.M., Cederna P.S., and Kuzon Jr. W.M. Terminolateral neurorrhaphy: A review of the literature. J Reconstr Microsurg 17 (2001) 615
35. Lundborg G., Zhao Q., Kanje M., et al. Can sensory and motor collateral sprouting be induced from intact peripheral nerve by end-to-side anastomosis?. J Hand Surg [Br] 19 (1994) 277
36. Ozbek S., Ozcan M., Noyan B., et al. End-to-side nerve coaptation: Is an additional proximal coaptation useful when available?. Ann Plast Surg 55 (2005) 281
37. Zhang Z., Soucacos P.N., Bo J., et al. Evaluation of collateral sprouting after end-to-side nerve coaptation using a fluorescent double-labeling technique. Microsurgery 19 (1999) 281