Confirmation of differential binding of Interferon Regulatory Factor-1 (IRF-1) to the functional and HIV disease-influencing -2578 A/G polymorphism in CCL2

Genes and Immunity

Volumn 10, Issue 2, 2009, Pages 197-198

  Mummidi, S ^a   Bonello, G B ^a   Ahuja, S K ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLYCINE; INTERFERON REGULATORY FACTOR 1; MONOCYTE CHEMOTACTIC PROTEIN 1;

BINDING AFFINITY; DEMENTIA; DNA RESPONSIVE ELEMENT; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOGENESIS; LETTER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

BASE SEQUENCE; BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CCL2; GUANINE; HIV INFECTIONS; HOMEODOMAIN PROTEINS; HUMANS; INTERFERON REGULATORY FACTOR-1; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS;

EID: 61849090826     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2008.75     Document Type: Letter

References (5)

1. Wright Jr EK, Page SH, Barber SA, Clements JE. Prep1/Pbx2 complexes regulate CCL2 expression through the -2578 guanine polymorphism. Genes Immun 2008; 9: 419-430.
2. Gonzalez E, Rovin BH, Sen L, Cooke G, Dhanda R, Mummidi S et al. HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci USA 2002; 99: 13795-13800.
3. Flores-Villanueva PO, Ruiz-Morales JA, Song CH, Flores LM, Jo EK, Montano M et al. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. J Exp Med 2005; 202: 1649-1658.
4. McDermott DH, Yang Q, Kathiresan S, Cupples LA, Massaro JM, Keaney Jr JF et al. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the framingham heart study. Circulation 2005; 112: 1113-1120.
5. Mummidi S, Adams LM, VanCompernolle SE, Kalkonde M, Camargo JF, Kulkarni H et al. Production of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells. J Immunol 2007; 178: 5668-5681.