PPI interactions with clopidogrel revisited

Medical Letter on Drugs and Therapeutics

Volumn 51, Issue 1306, 2009, Pages 13-14

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; CYTOCHROME P450 2C19; FAMOTIDINE; HISTAMINE H2 RECEPTOR ANTAGONIST; NIZATIDINE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; RANITIDINE; ANTITHROMBOCYTIC AGENT; CYP2C19 PROTEIN, HUMAN; DRUG DERIVATIVE; TICLOPIDINE; UNSPECIFIC MONOOXYGENASE;

ACUTE HEART INFARCTION; DRUG ACTIVATION; DRUG ANTAGONISM; ENZYME ACTIVITY; ENZYME INHIBITION; GASTROINTESTINAL HEMORRHAGE; GENETIC POLYMORPHISM; HUMAN; PRACTICE GUIDELINE; RISK REDUCTION; SHORT SURVEY; ARTICLE; CLINICAL TRIAL; GENETICS; METABOLISM;

ARYL HYDROCARBON HYDROXYLASES; CLINICAL TRIALS AS TOPIC; DRUG ANTAGONISM; HUMANS; PLATELET AGGREGATION INHIBITORS; POLYMORPHISM, GENETIC; PROTON PUMP INHIBITORS; TICLOPIDINE;

EID: 61849088896     PISSN: 0025732X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (7)

1. DL Bhatt et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol 2008; 52:1502.
2. PPI interactions with clopidogrel. Med Lett Drugs Ther 2009; 51:2.
3. JL Mega et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009; 360:354.
4. T Simon et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009; 360:363.
5. J-P Collet et al. Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study. Lancet 2009; 373:309.
6. XQ Li et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos 2004; 32:821.
7. DN Juurlink et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ 2008; 180. epub.