A pilot study testing a medication algorithm to reduce polypharmacy

Quality and Safety in Health Care

Volumn 18, Issue 1, 2009, Pages 55-58

  Mistler, L A ^a,b   Mellman, T A ^c   Drake, R E ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b VA MEDICAL CENTER   (United States)

^c HOWARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALGORITHMS; ANTIPSYCHOTIC AGENTS; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; PILOT PROJECTS; POLYPHARMACY; PSYCHOTIC DISORDERS;

EID: 61849087278     PISSN: 14753898     EISSN: 14753901     Source Type: Journal    
DOI: 10.1136/qshc.2007.024471     Document Type: Article

References (24)

1. Barbui C, Nose M, Mazzi MA, et al. Persistence with polypharmacy and excessive dosing in patients with schizophrenia treated in four European countries. Int Clin Psychopharmacol 2006; 21:355-62.
2. Biancosino B, Barbui C, Marmai L, et al. Determinants of antipsychotic polypharmacy in psychiatric inpatients: A prospective study. Int Clin Psychopharmacol 2005; 20:305-9.
3. Chakos MH, Glick ID, Miller AL, et al. Baseline use of concomitant psychotropic medications to treat schizophrenia in the CATIE trial. Psychiatr Serv 2006; 57:1094-101.
4. Gadit AA. Polypharmacy practice in psychiatry. J Coll Physicians Surg Pak 2005; 15:451-3.
5. Jaffe AB, Levine J. Antipsychotic medication coprescribing in a large state hospital system. Pharmacoepidemiol Drug Saf 2003; 12:41-8.
6. McCue RE, Waheed R, Urcuyo L. Polypharmacy in patients with schizophrenia. J Clin Psychiatry 2003; 64:984-9.
7. Procyshyn RM, Kennedy NB, Tse G, et al. Antipsychotic polypharmacy: A survey of discharge prescriptions from a tertiary care psychiatric institution. Can J Psychiatry 2001; 46:334-9.
8. Procyshyn RM, Thompson B. Patterns of antipsychotic utilization in a tertiary care psychiatric institution. Pharmacopsychiatry 2004; 37:12-17.
9. Sim K, Su A, Fujii S, et al. Antipsychotic polypharmacy in patients with schizophrenia: A multicentre comparative study in east asia. Br J Clin Pharmacol 2004; 58:178-83.
10. Stahl SM. Antipsychotic polypharmacy: Squandering precious resources? J Clin Psychiatry 2002; 63:93-4.
11. Stahl SM. Antipsychotic polypharmacy: Evidence based or eminence based? Acta Psychiatr Scand 2002; 106:321-2.
12. Stahl SM. Antipsychotic polypharmacy, part 1: Therapeutic option or dirty little secret? J Clin Psychiatry 1999; 60:425-6.
13. Stahl SM, Grady MM. A critical review of atypical antipsychotic utilization: Comparing monotherapy with polypharmacy and augmentation. Curr Med Chem 2004; 11:313-27.
14. Suzuki T, Uchida H, Tanaka KF, et al. Revising polypharmacy to a single antipsychotic regimen for patients with chronic schizophrenia. Int J Neuropsychopharmacol 2004; 7:133-42.
15. West JC, Wilk JE, Olfson M, et al. Patterns and quality of treatment for patients with schizophrenia in routine psychiatric practice. Psychiatr Serv 2005; 56:283-91.
16. Clark RE, Bartels SJ, Mellman TA, et al. Recent trends in antipsychotic combination therapy of schizophrenia and schizoaffective disorder: Implications for state mental health policy. Schizophr Bull 2002; 28:75-84.
17. Khan AY, Preskorn SH. Multiple medication use in general practice and psychiatry: So what? Psychiatr Times 2005; 22:8-10.
18. Ananth J, Parameswaran S, Gunatilake S. Antipsychotic polypharmacy. Curr Pharm Des 2004; 10:2231-8.
19. Buchanan RW, Kirkpatrick B, Bryant N, et al. Fluoxetine augmentation of clozapine treatment in patients with schizophrenia. Am J Psychiatry 1996; 153:1625-7.
20. Mellman TA, Miller AL, Weissman EM, et al. Evidence-based pharmacologic treatment for people with severe mental illness: A focus on guidelines and algorithms. Psychiatr Serv 2001; 52:619-25.
21. Rush AJ, Rago WV, Crismon ML, et al. Medication treatment for the severely and persistently mentally ill: The texas medication algorithm project. J Clin Psychiatry 1999; 60:284-91.
22. Deegan PE, Drake RE. Shared decision making and medication management in the recovery process. Psychiatr Serv 2006; 57:1636-9.
23. Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep 1962; 10:799-812.
24. Glick ID, Pham D, Davis JM. Concomitant medications may not improve outcome of antipsychotic monotherapy for stabilized patients with nonacute schizophrenia. J Clin Psychiatry 2006; 67:1261-5.