Seroepidemiology of EBV and interpretation of the "isolated VCA IgG" pattern

Journal of Medical Virology

Volumn 81, Issue 2, 2009, Pages 325-331

  De Paschale, Massimo ^a   Agrappi, Carlo ^a   Manco, Maria Teresa ^a   Mirri, Paola ^a   Viganò, Egidio Franco ^a   Clerici, Pierangelo ^a  

^a Hospital of Legnano   (Italy)

Author keywords

ELISA; Immunoblotting; Mononucleosis; Serological pattern

Indexed keywords

HETEROPHILE ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; VIRUS CAPSID ANTIGEN; CAPSID PROTEIN; EBV ENCODED NUCLEAR ANTIGEN 1; EBV-ENCODED NUCLEAR ANTIGEN 1; EPSTEIN BARR VIRAL CAPSID ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN; EPSTEIN-BARR VIRAL CAPSID ANTIGEN; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; HUMAN; IMMUNOBLOTTING; INFANT; MAJOR CLINICAL STUDY; MALE; OUTPATIENT CARE; PREVALENCE; SEROEPIDEMIOLOGY; VIRUS INFECTION; AGE DISTRIBUTION; BLOOD; CLASSIFICATION; EPIDEMIOLOGY; IMMUNOLOGY; INFECTIOUS MONONUCLEOSIS; ISOLATION AND PURIFICATION; MIDDLE AGED; PRESCHOOL CHILD; VIROLOGY;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CAPSID PROTEINS; CHILD; CHILD, PRESCHOOL; EPSTEIN-BARR VIRUS INFECTIONS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN G; INFANT; INFECTIOUS MONONUCLEOSIS; MALE; MIDDLE AGED; SEROEPIDEMIOLOGIC STUDIES; YOUNG ADULT;

HUMAN HERPESVIRUS 4;

EID: 61749094742     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21373     Document Type: Article

References (23)

1. Bauer G. 1995. The rational basis for efficient Epstein-Barr virus (EBV) serology. Clin Lab 41:623-634.
2. Bauer G. 2001. Simplicity through complexity: Immunoblot with recombinant antigens as the new gold standard in Epstein-Barr virus serology. Clin Lab 47:223-230.
3. Chan KH, Ng MH, Seto WH, Peiris JSM. 2001. Epstein-Barr virus (EBV) DNA in sera of patients with primary EBV infection. J Clin Microbiol 39:4152-4154.
4. Epstein MA, Achong BG. The EBV virus. 1973. Annu Rev Microbiol 27:413-436.
5. Evans AS, Niederman JC. 1982. Epstein-Barr virus. In: Evans AS, editor. Viral infection of humans, epidemiology and control. New York: Plenum Medical Book Company. pp. 253-281.
6. Gärtner BC, Hess RD, Bandt D, Kruse A, Rethwilm A, Roemer K, Mueller-Lantzsch N. 2003. Evaluation of four commercially available Epstein-Barr virus enzyme immunoassay with an immunofluorescence assay as the reference method. Clin Diagn Lab Immunol 10:78-82.
7. Henle W, Henle G, Andersson J, Emberg I, Klein G, Horwitz CA, Marklund G, Rymo L, Wellinder C, Straus SE. 1987. Antibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection. Proc Natl Acad Sci USA 84:570-574.
8. Hess RD. 2004. Routine Epstein-Barr Virus diagnostics from the laboratory perspective: Still challenging after 35 years. J Clin Microbiol 42:3381-3387.
9. Hoffman GJ, Lazarowitz SG, Hayward SD. 1980. Monoclonal antibody against a 250,000-dalton glycoprotein of Epstein-Barr virus identifies a membrane antigen and a neutralizing antigen. Proc Natl Acad Sci USA 77:2979-2983.
10. Holmes RD, Sokol RJ. 2002. Epstein-Barr virus post-transplant lymphoproliferative disease. Pediatr Transplant 6:456-464.
11. Kampmann M, Henninger K, Bauer G. 1993. Determination of antibodies directed specifically against Epstein-Barr virus nuclear antigen-1 (EBNA-1) by anticomplementary immunofluorescence (ACIF). Med Microbiol Lett 2:1-8.
12. Lennette ET. 1995. Epstein-Barr virus (EBV). In: Lennette EH, Lennette DA, Lennette ET, editors. Diagnostic procedures for viral, rickettsial, and chlamydial infections. Washington: American Public Health Association. pp. 299-312.
13. Luderer R, Kok M, Niesters HG, Schuurman R, de Weerdt O, Thijsen SF. 2005. Real-Time Epstein-Barr virus PCR for the diagnosis of primary EBV infection and EBV reactivation. Mol Diagn 9:195-200.
14. Miller G, Grogan E, Rowe D, Rooney C, Heston L, Eastman R, Andiman W, Niederman J, Lenoir G, Henle W, Sullivan J, Schooley R, Vossen J, Strauss S, Issekutz T. 1987. Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection. J Infect Dis 156:26-35.
15. Nikoskelainen J, Leikola J, Klemola E. 1974. IgM antibodies specific for Epstein-Barr virus in infectious mononucleosis without heterophil antibodies. Br Med J 4:72-75.
16. Rickinson AB, Kieff E. 2001. Epstein-Barr virus. In: Knipe DM, Howley PM, Griffin DE, Martin MA, Lamb RA, Roizman B, editors. Field virology. Philadelphia: Lippincott Williams & Wilkins. pp. 2575-2627.
17. Schillinger M, Kampmann M, Henninger K, Murray G, Hanselmann I, Bauer G. 1993. Variability of humoral immune response to acute Epstein-Barr virus (EBV) infection: Evaluation of the significance of serological markers. Med Microbiol Lett 2:296-303.
18. Schmitz H, Volz D, Krainick-Riechert CH, Scherer M. 1972. Acute Epstein-Barr virus infections in children. Med Microbiol Immunol 158:58-63.
19. Schubert J, Zens W, Weissbrich B. 1998. Comparative evaluation of the use of immunoblots and of IgG avidity assays as confirmatory tests for the diagnosis of acute EBV infections. J Clin Virol 11:161-172.
20. Steven NM. 1996. Infectious mononucleosis. EBV Reports 3:91-95.
21. Svahn A, Magnusson M, Jägdahl L, Schloss L, Kahlmeter G, Linde A. 1997. Evaluation of three commercial enzyme-linked immunosorbent assays and two latex agglutination assays for diagnosis of primary Epstein-Barr virus infection. J Clin Microbiol 35:2728-2732.
22. Thorley-Lawson DA, Geilinger K. 1980. Monoclonal antibodies against the major glycoprotein (gp 350/220) of Epstein-Barr virus neutralize infectivity. Proc Natl Acad Sci USA 77:5307-5311.
23. Vetter V, Kreutzer L, Bauer G. 1994. Differentiation of primary from secondary anti-EBNA-1-negative cases by determination of avidity of VCA-IgG. Clin Diagn Virol 2:29-39.